Vet. Sci., Volume 6, Issue 4 (December 2019) – 29 articles
Cover Story (view full-size image): Our group has discovered and developed a surface antigen for Mycobacterium avium subspecies paratuberculosis (Map), the bacterium that causes Johne's disease (JD). This antigen, termed an ethanol extract, has shown strong potential for use in a diagnostic test for JD. The problem is that the antigen has a complex makeup consisting of lipid, carbohydrate, and proteins, and thus, it would be beneficial to determine more precisely what these components are and if they are necessary for the antigenicity of diagnostic tests. We discovered that it is the carbohydrate component and not the proteins that are antigenic. We further defined what some of these components are within the extract. This new knowledge should enable researchers to engineer or refine this antigen using only the most immunogenic components to improve diagnostic tests. View this paper
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