Next Article in Journal
Correction: Alvarez, I., et al. Detection of Bovine Leukemia Virus RNA in Blood Samples of Naturally Infected Dairy Cattle. Vet. Sci. 2019, 6, 66
Previous Article in Journal
Development and Evaluation of Epitope-Blocking ELISA for Detection of Antibodies against Contagious Caprine Pleuropneumonia in Goat Sera
Open AccessReview

Development of Dog Immune System: From in Uterus to Elderly

1
Global Health and Tropical Medicine (GHTM), Instituto de Higiene e Medicina Tropical (IHMT), Universidade Nova de Lisboa (UNL), R. da Junqueira 100, 1349-008 Lisboa, Portugal
2
Instituto Politécnico de Portalegre (IPP), Praça do Município 11, 7300-110 Portalegre, Portugal
3
Agrarian School of the Polytechnic Institute of Viseu, Quinta da Alagoa—Estrada de Nelas Ranhados, 3500-606 Viseu, Portugal
4
Centro Interdisciplinar de Investigação em Sanidade Animal (CIISA), Faculdade de Medicina Veterinária (FMV), Universidade de Lisboa (UL), Av. Universidade Técnica, 1300-477 Lisboa, Portugal
*
Author to whom correspondence should be addressed.
Vet. Sci. 2019, 6(4), 83; https://doi.org/10.3390/vetsci6040083
Received: 16 August 2019 / Revised: 10 October 2019 / Accepted: 12 October 2019 / Published: 21 October 2019
(This article belongs to the Section Microbiology and Immunology)
Immune system recognize and fight back foreign microorganisms and inner modifications that lead to deficient cell and tissue functions. During a dog’s life, the immune system needs to adapt to different physiological conditions, assuring surveillance and protection in a careful and controlled way. Pregnancy alters normal homeostasis, requiring a balance between immunity and tolerance. The embryos and fetus should be protected from infections, while the female dog must tolerate the growing of semi-allografts in her uterus. After birth, newborn puppies are at great risk of developing infectious diseases, because their immune system is in development and immune memory is absent. Passive transfer of immunity through colostrum is fundamental for puppy survival in the first weeks of life, but hampers the development of an active immune response to vaccination. At the end of life, dogs experience a decline in the structure and functional competence of the immune system, compromising the immune responses to novel antigenic challenges, such as infections and vaccines. Therefore, the current article reviews the general processes related to the development of the dog´s immune system, providing an overview of immune activity throughout the dog’s life and its implications in canine health, and highlighting priority research goals. View Full-Text
Keywords: dog; immune system; immunity; passive immune transfer; immunity development dog; immune system; immunity; passive immune transfer; immunity development
Show Figures

Figure 1

MDPI and ACS Style

Pereira, M.; Valério-Bolas, A.; Saraiva-Marques, C.; Alexandre-Pires, G.; Pereira da Fonseca, I.; Santos-Gomes, G. Development of Dog Immune System: From in Uterus to Elderly. Vet. Sci. 2019, 6, 83.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop