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Bioengineering, Volume 9, Issue 12

2022 December - 101 articles

Cover Story: Cell-based treatments to replace lost or damaged insulin-secreting β cells is a promising approach in the treatment of diabetes. A favored method is to protect the cells within an implant device, and therefore the design of an internal environment within the implant that supports cell function would be beneficial. To test the impact of different environments we reaggregated isolated native pancreatic β cells to form small spheroids which we then embedded in alginate. We show that spheroids embedded in RGD-conjugated alginate orientate with respect to the outer surface with the enrichment of activated focal adhesions. Our functional assays show that glucose-dependent insulin secretion is increased with RGD-conjugated peptide compared to control alginate, and secretion is further enhanced in softer alginate gels. View this paper
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Articles (101)

  • Article
  • Open Access
9 Citations
3,080 Views
14 Pages

Design, Structural Characteristic and Antibacterial Performance of Silver-Containing Cotton Fiber Nanocomposite

  • Rasim Alosmanov,
  • Irada Buniyat-zadeh,
  • Mustafa Soylak,
  • Azad Shukurov,
  • Solmaz Aliyeva,
  • Sinan Turp and
  • Gulnara Guliyeva

In the present study, cotton fiber was treated with phosphorus trichloride in the presence of oxygen. As a result of the subsequent hydrolysis of modified cotton fibers, phosphorus-containing fragments with acidic groups and chlorine atoms were intro...

  • Article
  • Open Access
14 Citations
5,185 Views
20 Pages

Automatic Localization of Seizure Onset Zone Based on Multi-Epileptogenic Biomarkers Analysis of Single-Contact from Interictal SEEG

  • Yiping Wang,
  • Yanfeng Yang,
  • Si Li,
  • Zichen Su,
  • Jinjie Guo,
  • Penghu Wei,
  • Jinguo Huang,
  • Guixia Kang and
  • Guoguang Zhao

Successful surgery on drug-resistant epilepsy patients (DRE) needs precise localization of the seizure onset zone (SOZ). Previous studies analyzing this issue still face limitations, such as inadequate analysis of features, low sensitivity and limite...

  • Review
  • Open Access
121 Citations
19,248 Views
22 Pages

A Review of Brain Activity and EEG-Based Brain–Computer Interfaces for Rehabilitation Application

  • Mostafa Orban,
  • Mahmoud Elsamanty,
  • Kai Guo,
  • Senhao Zhang and
  • Hongbo Yang

Patients with severe CNS injuries struggle primarily with their sensorimotor function and communication with the outside world. There is an urgent need for advanced neural rehabilitation and intelligent interaction technology to provide help for pati...

  • Review
  • Open Access
18 Citations
9,533 Views
17 Pages

Application of Precision-Cut Lung Slices as an In Vitro Model for Research of Inflammatory Respiratory Diseases

  • Yan Liu,
  • Ping Wu,
  • Yin Wang,
  • Yansong Liu,
  • Hongfang Yang,
  • Guohua Zhou,
  • Xiaoqi Wu and
  • Qingping Wen

The leading cause of many respiratory diseases is an ongoing and progressive inflammatory response. Traditionally, inflammatory lung diseases were studied primarily through animal models, cell cultures, and organoids. These technologies have certain...

  • Article
  • Open Access
34 Citations
5,027 Views
18 Pages

Gold nanoparticles (GNPs) have immense potential in biomedicine, but understanding their interactions with serum proteins is crucial as it could change their biological profile due to the formation of a protein corona, which could then affect their u...

  • Article
  • Open Access
9 Citations
3,248 Views
14 Pages

Hyper-Branched Cyclodextrin-Based Polymers as Anticoagulant Agents: In Vitro and In Vivo Studies

  • Yousef Khazaei Monfared,
  • Mohammad Mahmoudian,
  • Gjylije Hoti,
  • Daniel Mihai Bisericaru,
  • Fabrizio Caldera,
  • Roberta Cavalli,
  • Parvin Zakeri-Milani,
  • Adrián Matencio and
  • Francesco Trotta

This study tested the anticoagulant effect of cyclodextrin (CD) hyper-branched-based polymers (HBCD-Pols). These polymers were synthesized and tested for their coagulant characteristics in vitro and in vivo. Due to their polymeric structure and anion...

  • Review
  • Open Access
27 Citations
5,160 Views
14 Pages

The Role of the Innate Immune System in Wear Debris-Induced Inflammatory Peri-Implant Osteolysis in Total Joint Arthroplasty

  • John Patrick Connors,
  • John W. Stelzer,
  • Patrick M. Garvin,
  • Ian J. Wellington and
  • Olga Solovyova

Periprosthetic osteolysis remains a leading complication of total hip and knee arthroplasty, often resulting in aseptic loosening of the implant and necessitating revision surgery. Wear-induced particulate debris is the main cause initiating this des...

  • Article
  • Open Access
3 Citations
2,451 Views
12 Pages

Is it Feasible to Use a Low-Cost Wearable Sensor for Heart Rate Monitoring within an Upper Limb Training in Spinal Cord Injured Patients?: A Pilot Study

  • Miriam Salas-Monedero,
  • Vicente Lozano-Berrio,
  • María-Jesús Cazorla-Martínez,
  • Silvia Ceruelo-Abajo,
  • Ángel Gil-Agudo,
  • Sonsoles Hernández-Sánchez,
  • José-Fernando Jiménez-Díaz and
  • Ana DelosReyes-Guzmán

(1) Background: Cervical spinal cord injury (SCI) patients have impairment in the autonomic nervous system, reflected in the cardiovascular adaption level during the performance of upper limb (UL) activities carried out in the rehabilitation process....

  • Review
  • Open Access
32 Citations
9,739 Views
25 Pages

Sensors and Techniques for On-Line Determination of Cell Viability in Bioprocess Monitoring

  • Laura S. Rösner,
  • Franziska Walter,
  • Christian Ude,
  • Gernot T. John and
  • Sascha Beutel

In recent years, the bioprocessing industry has experienced significant growth and is increasingly emerging as an important economic sector. Here, efficient process management and constant control of cellular growth are essential. Good product qualit...

  • Article
  • Open Access
13 Citations
11,234 Views
10 Pages

Background: A newly available gel containing hyaluronic acid (HA) and polyvinylpyrrolidone was tested for efficacy on traumatic oral ulcers (TOU) caused by fixed orthodontic appliances. Methods: A double-blind RCT was conducted to test the new gel ve...

  • Article
  • Open Access
7 Citations
3,061 Views
11 Pages

Surface Accumulation of Cerium, Self-Assembling Peptide, and Fluoride on Sound Bovine Enamel

  • Konstantin Johannes Scholz,
  • Karl-Anton Hiller,
  • Helga Ebensberger,
  • Gerlinde Ferstl,
  • Florian Pielnhofer,
  • Tobias T. Tauböck,
  • Klaus Becker and
  • Wolfgang Buchalla

The accumulation of caries-preventive compounds on sound enamel is crucial in order to improve the inhibition of carious lesion initiation. The aim of this research was to investigate the initial accumulation of cerium, oligopeptide p11-4, and fluori...

  • Review
  • Open Access
8 Citations
3,459 Views
15 Pages

Low temperatures have a negative effect on plant development. Plants that are exposed to cold temperatures undergo a cascade of physiological, biochemical, and molecular changes that activate several genes, transcription factors, and regulatory pathw...

  • Article
  • Open Access
13 Citations
2,622 Views
14 Pages

Development of a Rice Plant Disease Classification Model in Big Data Environment

  • Shampa Sengupta,
  • Abhijit Dutta,
  • Shaimaa A. M. Abdelmohsen,
  • Haifa A. Alyousef and
  • Mohammad Rahimi-Gorji

More than the half of the global population consume rice as their primary energy source. Therefore, this work focused on the development of a prediction model to minimize agricultural loss in the paddy field. Initially, rice plant diseases, along wit...

  • Case Report
  • Open Access
8 Citations
5,795 Views
9 Pages

Maxillary Premolars with Four Canals: Case Series

  • Calogero Bugea,
  • Denise Irene Karin Pontoriero,
  • Gaia Rosenberg,
  • Giacomo Mario Gerardo Suardi,
  • Gianmarco Calabria,
  • Eugenio Pedullà,
  • Giusy Rita Maria La Rosa,
  • Francesco Sforza,
  • Antonio Scarano and
  • Giovanni Messina
  • + 1 author

The aim of this case series is to contribute to the better knowledge and management of the complex anatomical configurations of maxillary premolars with four canals. The paper explains the endodontic treatment of five maxillary premolars with four ca...

  • Article
  • Open Access
17 Citations
5,203 Views
12 Pages

Water-Absorbing Bioadhesive Poly(Acrylic Acid)/Polyvinylpyrrolidone Complex Sponge for Hemostatic Agents

  • Tomoko Ito,
  • Shingo Yamaguchi,
  • Daisuke Soga,
  • Keisuke Ueda,
  • Takayuki Yoshimoto and
  • Yoshiyuki Koyama

Background: Poly(acrylic acid) (PAA) is a water-soluble synthetic polymer with tissue-adhesive properties. When PAA is mixed with polyvinylpyrrolidone (PVP) in water, it forms a water-insoluble precipitate that neither swells nor adheres to tissues....

  • Article
  • Open Access
4 Citations
3,004 Views
13 Pages

Automatic Assessment of Procedural Skills Based on the Surgical Workflow Analysis Derived from Speech and Video

  • Carmen Guzmán-García,
  • Patricia Sánchez-González,
  • Ignacio Oropesa and
  • Enrique J. Gómez

Automatic surgical workflow analysis (SWA) plays an important role in the modelling of surgical processes. Current automatic approaches for SWA use videos (with accuracies varying from 0.8 and 0.9), but they do not incorporate speech (inherently link...

  • Article
  • Open Access
2 Citations
2,616 Views
14 Pages

Controlled Release of Encapsuled Stromal-Derived Factor 1α Improves Bone Marrow Mesenchymal Stromal Cells Migration

  • Karolina Bajdak-Rusinek,
  • Agnieszka Fus-Kujawa,
  • Katarzyna Jelonek,
  • Monika Musiał-Kulik,
  • Piotr Paweł Buszman,
  • Dorota Żyła-Uklejewicz,
  • Adrianna Walentyna Sekowska,
  • Janusz Kasperczyk and
  • Paweł Eugeniusz Buszman

Stem cell treatment is a promising method of therapy for the group of patients whose conventional options for treatment have been limited or rejected. Stem cells have the potential to repair, replace, restore and regenerate cells. Moreover, their pro...

  • Article
  • Open Access
1 Citations
2,028 Views
21 Pages

Using a phosphene has been discussed as a means of informing the visually impaired of the position of an obstacle. Obstacles underfoot have a risk, so it is necessary to inform the visually impaired. A previous study clarified a method of presenting...

  • Review
  • Open Access
15 Citations
8,449 Views
13 Pages

The goal of this systematic review was to examine existing evidence on the effectiveness of early, progressive weight bearing on patients after traumatic lower extremity fractures and relate these findings to device/implant choice. A search of the li...

  • Article
  • Open Access
8 Citations
3,109 Views
13 Pages

Structural Evaluation and Conformational Dynamics of ZNF141T474I Mutation Provoking Postaxial Polydactyly Type A

  • Yasir Ali,
  • Faisal Ahmad,
  • Muhammad Farhat Ullah,
  • Noor Ul Haq,
  • M. Inam Ul Haq,
  • Abdul Aziz,
  • Ferjeni Zouidi,
  • M. Ijaz Khan and
  • Sayed M. Eldin

Postaxial Polydactyly (PAP) is a congenital disorder of limb abnormalities characterized by posterior extra digits. Mutations in the N-terminal region of the Zinc finger protein 141 (ZNF141) gene were recently linked with PAP type A. Zinc finger prot...

  • Systematic Review
  • Open Access
34 Citations
7,110 Views
29 Pages

Background: Non-alcoholic Fatty Liver Disease (NAFLD) is growing more prevalent worldwide. Although non-invasive diagnostic approaches such as conventional ultrasonography and clinical scoring systems have been proposed as alternatives to liver biops...

  • Review
  • Open Access
4 Citations
3,351 Views
14 Pages

The attention on orthopedic biomaterials has shifted from their direct osteogenic properties to their osteoimmunomodulation, especially the modulation of macrophage polarization. Presently, advanced technologies endow polyetheretherketone (PEEK) with...

  • Article
  • Open Access
8 Citations
4,149 Views
13 Pages

Watermelon is an important fruit that is widely distributed around the world. In particular, the production and consumption of watermelon in China ranks first in the world. Watermelon production is severely affected by a variety of biotic and abiotic...

  • Review
  • Open Access
2 Citations
2,678 Views
13 Pages

Enhancing Molecular Testing for Effective Delivery of Actionable Gene Diagnostics

  • Árpád Ferenc Kovács,
  • Zaránd Némethi,
  • Tünde Abonyi,
  • György Fekete and
  • Gábor T. Kovács

There is a deep need to navigate within our genomic data to find, understand and pave the way for disease-specific treatments, as the clinical diagnostic journey provides only limited guidance. The human genome is enclosed in every nucleated cell, an...

  • Review
  • Open Access
14 Citations
6,484 Views
22 Pages

Tissue Engineering Applied to Skeletal Muscle: Strategies and Perspectives

  • Ana Luisa Lopes Martins,
  • Luciana Pastena Giorno and
  • Arnaldo Rodrigues Santos

Muscle tissue is formed by elongated and contractile cells with specific morphofunctional characteristics. Thus, it is divided into three basic types: smooth muscle tissue, cardiac striated muscle tissue and skeletal striated muscle tissue. The stria...

  • Article
  • Open Access
12 Citations
4,430 Views
10 Pages

Proprioception is essential for neuromuscular control in relation to sport injury and performance. The effect of landing heights and loads on ankle inversion proprioceptive performance in individuals with or without chronic ankle instability (CAI) ma...

  • Article
  • Open Access
6 Citations
3,266 Views
17 Pages

The hyaluronic acid (HA) hydrogel array was employed for immobilization of 5-fluorouracil (5-FU), and the electrospun bilayer (hydrophilic: polyurethane/pluronic F-127 and hydrophobic: polyurethane) membrane was used to support the HA hydrogel array...

  • Article
  • Open Access
5 Citations
2,916 Views
16 Pages

Deformations or remodeling of the lamina cribrosa (LC) induced by elevated intraocular pressure (IOP) are associated with optic nerve injury. The quantitative analysis of the morphology changes of the LC will provide the basis for the study of the pa...

  • Review
  • Open Access
5 Citations
3,219 Views
18 Pages

Ovarian, cervical, and endometrial cancer are the three most common gynecological malignancies that seriously threaten women’s health. With the development of molecular biology technology, immunotherapy and targeted therapy for gynecologic tumo...

  • Article
  • Open Access
8 Citations
4,257 Views
17 Pages

Kinetics of Biodiesel Production from Microalgae Using Microbubble Interfacial Technology

  • Fahed Javed,
  • Muhammad Waqas Saif-ul-Allah,
  • Faisal Ahmed,
  • Naim Rashid,
  • Arif Hussain,
  • William B. Zimmerman and
  • Fahad Rehman

As an alternative to fossil fuels, biodiesel can be a source of clean and environmentally friendly energy source. However, its commercial application is limited by expensive feedstock and the slow nature of the pretreatment step-acid catalysis. The c...

  • Article
  • Open Access
11 Citations
4,836 Views
17 Pages

Establishment of a Serum-Free Hepatocyte Cryopreservation Process for the Development of an “Off-the-Shelf” Bioartificial Liver System

  • Ji-Hyun Lee,
  • Hey-Jung Park,
  • Young-A Kim,
  • Doo-Hoon Lee,
  • Jeong-Kwon Noh,
  • Jong-Gab Jung,
  • Hee-Hoon Yoon,
  • Suk-Koo Lee and
  • Sanghoon Lee

To use hepatocytes immediately when necessary for hepatocyte transplantation and bioartificial liver (BAL) systems, a serum-free cryopreservation protocol ensuring the high survival of hepatocytes and maintenance of their functions should be develope...

  • Article
  • Open Access
16 Citations
3,879 Views
15 Pages

In this study, we propose a deep learning framework and a self-supervision scheme for video-based surgical gesture recognition. The proposed framework is modular. First, a 3D convolutional network extracts feature vectors from video clips for encodin...

  • Feature Paper
  • Article
  • Open Access
10 Citations
4,321 Views
16 Pages

Wave-Encoded Model-Based Deep Learning for Highly Accelerated Imaging with Joint Reconstruction

  • Jaejin Cho,
  • Borjan Gagoski,
  • Tae Hyung Kim,
  • Qiyuan Tian,
  • Robert Frost,
  • Itthi Chatnuntawech and
  • Berkin Bilgic

A recently introduced model-based deep learning (MoDL) technique successfully incorporates convolutional neural network (CNN)-based regularizers into physics-based parallel imaging reconstruction using a small number of network parameters. Wave-contr...

  • Article
  • Open Access
34 Citations
6,165 Views
22 Pages

Pomegranate Pomace Extract with Antioxidant, Anticancer, Antimicrobial, and Antiviral Activity Enhances the Quality of Strawberry-Yogurt Smoothie

  • Nouf H. Alsubhi,
  • Diana A. Al-Quwaie,
  • Ghadeer I. Alrefaei,
  • Mona Alharbi,
  • Najat Binothman,
  • Majidah Aljadani,
  • Safa H. Qahl,
  • Fatima A. Jaber,
  • Mashael Huwaikem and
  • Ahmed Saad
  • + 3 authors

Valorizing the wastes of the food industry sector as additives in foods and beverages enhances human health and preserves the environment. In this study, pomegranate pomace (PP) was obtained from the company Schweppes and exposed to the production of...

  • Article
  • Open Access
10 Citations
3,751 Views
12 Pages

Chronic refractory wounds are one of the complications of diabetes mellitus that require effective therapy. The dermal-wound-healing property of IL-33 in diabetics is little understood. Therefore, this study aimed to express recombinant humanized mat...

  • Article
  • Open Access
2 Citations
2,522 Views
12 Pages

Intravascular Ultrasonography (IVUS)—A Tool for Imaging the Eustachian Tube?

  • Niels Oppel,
  • Gerrit Paasche,
  • Andre Bleich,
  • Thomas Lenarz and
  • Robert Schuon

The Eustachian tube (ET) has a key role in the pathogenesis of otitis media. Until now, there has been a lack of meaningful imaging methods to investigate the ET and its surrounding tissue. The aim of the current study was to investigate the possibil...

  • Article
  • Open Access
2 Citations
4,358 Views
15 Pages

Hybrid Distractor for Continuous Mandibular Distraction Osteogenesis

  • Shahrokh Hatefi,
  • Javad Alizargar,
  • Yimesker Yihun,
  • Milad Etemadi Sh,
  • Nan-Chen Hsieh and
  • Khaled Abou-El-Hossein

Distraction osteogenesis (DO) is a reconstruction method for repairing bone deficiencies in the oral and maxillofacial area. Manual DO techniques have shown the functionality of the DO method for bone tissue reconstruction. The DO method can improve...

  • Article
  • Open Access
17 Citations
3,324 Views
9 Pages

Background and objectives: Pulsed Electric Field (PEF) ablation has been proposed as a non-thermal energy to treat atrial fibrillation (AF) by epicardial ablation of ganglionated plexi (GP), which are embedded within epicardial fat. Our objective was...

  • Article
  • Open Access
2 Citations
2,895 Views
15 Pages

Effects of Electrical Pulse Width and Output Irradiance on Intense Pulse Light Inactivation

  • Shuge Xie,
  • Diya Shen,
  • Qing Yuan,
  • Zairui Wu,
  • Junyuan Wang,
  • Fusheng Li,
  • Qiuyi Han and
  • Shanduan Zhang

The effects of electrical pulse width and output irradiance on the inactivation effect of intense pulse light (IPL) are studied in this paper. The measured radiant efficiency of pulsed xenon lamp can be more than 50%, and its irradiance can reach lev...

  • Article
  • Open Access
6 Citations
2,453 Views
14 Pages

New Insight into Muscle-Type Cofilin (CFL2) as an Essential Mediator in Promoting Myogenic Differentiation in Cattle

  • Yujia Sun,
  • Tianqi Zhao,
  • Yaoyao Ma,
  • Xinyi Wu,
  • Yongjiang Mao,
  • Zhangping Yang and
  • Hong Chen

Meat quality and meat composition are not separated from the influences of animal genetic improvement systems; the growth and development of skeletal muscle are the primary factors in agricultural meat production and meat quality. Though the muscle-t...

  • Article
  • Open Access
2 Citations
2,872 Views
12 Pages

Bi-manual therapy (BT), mirror therapy (MT), and robot-assisted rehabilitation have been conducted in hand training in a wide range of stages in stroke patients; however, the mechanisms of action during training remain unclear. In the present study,...

  • Review
  • Open Access
67 Citations
14,023 Views
39 Pages

Scaffold Fabrication Techniques of Biomaterials for Bone Tissue Engineering: A Critical Review

  • Sakchi Bhushan,
  • Sandhya Singh,
  • Tushar Kanti Maiti,
  • Chhavi Sharma,
  • Dharm Dutt,
  • Shubham Sharma,
  • Changhe Li and
  • Elsayed Mohamed Tag Eldin

Bone tissue engineering (BTE) is a promising alternative to repair bone defects using biomaterial scaffolds, cells, and growth factors to attain satisfactory outcomes. This review targets the fabrication of bone scaffolds, such as the conventional an...

  • Review
  • Open Access
49 Citations
8,994 Views
32 Pages

Communication, neuro-prosthetics, and environmental control are just a few applications for disabled persons who use robots and manipulators that use brain-computer interface (BCI) systems. The brain’s motor imagery (MI) signal is an essential...

  • Article
  • Open Access
4 Citations
3,176 Views
7 Pages

This study aimed to investigate the changes in preexisting temporomandibular joint (TMJ) clicking and the new incidence of TMJ clicking after orthognathic surgery. A total of 60 patients (30 men and 30 women) with mandibular prognathism underwent int...

  • Article
  • Open Access
7 Citations
3,385 Views
12 Pages

The Effect of Concave-Side Intertransverse Ligament Laxity on the Stress of AIS Lumbar Spine Based on Finite Element Method

  • Linjie Zhang,
  • Qiaolin Zhang,
  • Yan Zhang,
  • Musinguzi Arthur,
  • Ee-Chon Teo,
  • István Bíró and
  • Yaodong Gu

(1) Background: Scoliosis has the mechanical characteristic of asymmetric stress distribution, which is one of the reasons for the aggravation of scoliosis. Bracing therapy is the best treatment for AIS, but it is difficult and costly to operate. Is...

  • Article
  • Open Access
4 Citations
4,213 Views
13 Pages

Type 1 diabetes results from the loss of pancreatic β cells, reduced insulin secretion and dysregulated blood glucose levels. Replacement of these lost β cells with stem cell-derived β cells, and protecting these cells within macro-dev...

  • Article
  • Open Access
8 Citations
3,898 Views
17 Pages

Investigation on the Modeling and Reconstruction of Head Injury Accident Using ABAQUS/Explicit

  • Xingqiao Deng,
  • Zhifei Du,
  • Huiling Feng,
  • Shisong Wang,
  • Heng Luo and
  • Yucheng Liu

A process of modeling and reconstructing human head injuries involved in traffic crashes based on ABAQUS/Explicit is presented in this paper. A high-fidelity finite element (FE) model previously developed by the authors is employed to simulate a real...

  • Article
  • Open Access
11 Citations
4,169 Views
16 Pages

Color medical images provide better visualization and diagnostic information for doctors during clinical procedures than grayscale medical images. Although generative adversarial network-based image colorization approaches have shown promising result...

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Bioengineering - ISSN 2306-5354