Skip to Content

Bioengineering, Volume 9, Issue 12

2022 December - 101 articles

Cover Story: Cell-based treatments to replace lost or damaged insulin-secreting β cells is a promising approach in the treatment of diabetes. A favored method is to protect the cells within an implant device, and therefore the design of an internal environment within the implant that supports cell function would be beneficial. To test the impact of different environments we reaggregated isolated native pancreatic β cells to form small spheroids which we then embedded in alginate. We show that spheroids embedded in RGD-conjugated alginate orientate with respect to the outer surface with the enrichment of activated focal adhesions. Our functional assays show that glucose-dependent insulin secretion is increased with RGD-conjugated peptide compared to control alginate, and secretion is further enhanced in softer alginate gels. View this paper
  • Issues are regarded as officially published after their release is announced to the table of contents alert mailing list .
  • You may sign up for email alerts to receive table of contents of newly released issues.
  • PDF is the official format for papers published in both, html and pdf forms. To view the papers in pdf format, click on the "PDF Full-text" link, and use the free Adobe Reader to open them.

Articles (101)

  • Article
  • Open Access
9 Citations
3,752 Views
9 Pages

The removal of filling material is important for successful root canal retreatment. The aim of the study was to compare the efficiency of two activated irrigation techniques, the shock wave-enhanced emission photoacoustic streaming (SWEEPS) mode of t...

  • Article
  • Open Access
10 Citations
10,649 Views
14 Pages

The aim of this study was to develop a facile and novel lipid-based formulation of vitamin C and vitamin D3. Liposomes loaded with vitamin C and D3 were characterized using transmission electron microscopy (TEM) and zeta potential measurements for ev...

  • Article
  • Open Access
10 Citations
3,057 Views
15 Pages

Physicochemical and Antioxidant Properties of Nanoliposomes Loaded with Rosemary Oleoresin and Their Oxidative Stability Application in Dried Oysters

  • Xiaoyu Cheng,
  • Mingwu Zang,
  • Shouwei Wang,
  • Xin Zhao,
  • Guozhen Zhai,
  • Le Wang,
  • Xiang Li,
  • Yan Zhao and
  • Yijing Yue

Lipid and protein oxidation is a main problem related to the preservation of dried aquatic products. Rosemary oleoresin is widely used as an antioxidant, but its application is limited due to its instability and easy degradation. Nanoliposome encapsu...

  • Technical Note
  • Open Access
15 Citations
9,911 Views
9 Pages

Platelet-Rich Plasma Gel Matrix (PRP-GM): Description of a New Technique

  • Thales Thiago Ferreira Godoi,
  • Bruno Lima Rodrigues,
  • Stephany Cares Huber,
  • Maria Helena Andrade Santana,
  • Lucas Furtado da Fonseca,
  • Gabriel Silva Santos,
  • Gabriel Ohana Marques Azzini,
  • Tomas Mosaner,
  • Chris Paulus-Romero and
  • José Fábio Santos Duarte Lana

Several musculoskeletal conditions are triggered by inflammatory processes that occur along with imbalances between anabolic and catabolic events. Platelet-rich plasma (PRP) is an autologous product derived from peripheral blood with inherent immunom...

  • Review
  • Open Access
2,555 Views
21 Pages

Polymeric Materials as Indispensable Tools to Fight RNA Viruses: SARS-CoV-2 and Influenza A

  • Ariana C. F. Santos,
  • Fátima Martel,
  • Carmen S. R. Freire and
  • Bárbara J. M. L. Ferreira

Towards the end of 2019 in Wuhan, suspicions of a new dangerous virus circulating in the air began to arise. It was the start of the world pandemic coronavirus disease 2019 (COVID-19). Since then, considerable research data and review papers about th...

  • Article
  • Open Access
8 Citations
3,702 Views
16 Pages

Synthesis of Carrier-Free Paclitaxel–Curcumin Nanoparticles: The Role of Curcuminoids

  • Sena Karaosmanoglu,
  • Yunsen Zhang,
  • Wenli Zhou,
  • Defang Ouyang and
  • Xianfeng Chen

The systemic administration of paclitaxel (PTX)-based combinatorial therapies is significantly restricted due to the multidrug resistance. Curcumin (CUR) not only inhibits cancer-cell proliferation but also reverses the PTX resistance. However, achie...

  • Article
  • Open Access
8 Citations
2,765 Views
17 Pages

Genomic Insight into Shimazuella Soli Sp. Nov. Isolated from Soil and Its Putative Novel Class II Lasso Peptide

  • Chun-Zhi Jin,
  • Jong Min Lee,
  • Chang-Jin Kim,
  • Hyung-Gwan Lee and
  • Kee-Sun Shin

The strain designated as AN120528T was isolated from farmland soil in South Korea. This strain grows well on R2A medium at 28 °C. The cells are an off-white colour and have no hyphae. The phylogenetic analysis indicated that the strain is a membe...

  • Article
  • Open Access
18 Citations
5,735 Views
15 Pages

Kidney–ureter–bladder (KUB) imaging is a radiological examination with a low cost, low radiation, and convenience. Although emergency room clinicians can arrange KUB images easily as a first-line examination for patients with suspicious u...

  • Article
  • Open Access
3 Citations
2,500 Views
16 Pages

The Osteogenic Potential of Falciform Ligament-Derived Stromal Cells—A Comparative Analysis between Two Osteogenic Induction Programs

  • Carla Ferreira-Baptista,
  • André Queirós,
  • Rita Ferreira,
  • Maria Helena Fernandes,
  • Bruno Colaço and
  • Pedro Sousa Gomes

Mesenchymal stromal cells (MSCs) have gained special relevance in bone tissue regenerative applications. MSCs have been isolated from different depots, with adipose tissue being acknowledged as one of the most convenient sources, given the wide avail...

  • Article
  • Open Access
11 Citations
3,153 Views
21 Pages

Reference Values for 3D Spinal Posture Based on Videorasterstereographic Analyses of Healthy Adults

  • Janine Huthwelker,
  • Jürgen Konradi,
  • Claudia Wolf,
  • Ruben Westphal,
  • Irene Schmidtmann,
  • Philipp Drees and
  • Ulrich Betz

Visual examinations are commonly used to analyze spinal posture. Even though they are simple and fast, their interrater reliability is poor. Suitable alternatives should be objective, non-invasive, valid and reliable. Videorasterstereography (VRS) is...

  • Review
  • Open Access
40 Citations
10,212 Views
11 Pages

Recent Advances in the Development of Bioreactors for Manufacturing of Adoptive Cell Immunotherapies

  • Irina Ganeeva,
  • Ekaterina Zmievskaya,
  • Aygul Valiullina,
  • Anna Kudriaeva,
  • Regina Miftakhova,
  • Alexey Rybalov and
  • Emil Bulatov

Harnessing the human immune system as a foundation for therapeutic technologies capable of recognizing and killing tumor cells has been the central objective of anti-cancer immunotherapy. In recent years, there has been an increasing interest in impr...

  • Article
  • Open Access
21 Citations
5,075 Views
13 Pages

Three-Dimensional Bioprinting with Alginate by Freeform Reversible Embedding of Suspended Hydrogels with Tunable Physical Properties and Cell Proliferation

  • Yuanjia Zhu,
  • Charles J. Stark,
  • Sarah Madira,
  • Sidarth Ethiraj,
  • Akshay Venkatesh,
  • Shreya Anilkumar,
  • Jinsuh Jung,
  • Seunghyun Lee,
  • Catherine A. Wu and
  • Yi-Ping Joseph Woo
  • + 2 authors

Extrusion-based three-dimensional (3D) bioprinting is an emerging technology that allows for rapid bio-fabrication of scaffolds with live cells. Alginate is a soft biomaterial that has been studied extensively as a bio-ink to support cell growth in 3...

  • Article
  • Open Access
4 Citations
3,019 Views
15 Pages

Effect of Citrate- and Gold-Stabilized Superparamagnetic Iron Oxide Nanoparticles on Head and Neck Tumor Cell Lines during Combination Therapy with Ionizing Radiation

  • Christoph Schreiber,
  • Tim Franzen,
  • Laura Hildebrand,
  • René Stein,
  • Bernhard Friedrich,
  • Rainer Tietze,
  • Rainer Fietkau and
  • Luitpold V. Distel

Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer worldwide. They are associated with alcohol and tobacco consumption, as well as infection with human papillomaviruses (HPV). Therapeutic options include radiochemotherapy,...

  • Article
  • Open Access
7 Citations
4,682 Views
23 Pages

Hypothermic Preservation of Adipose-Derived Mesenchymal Stromal Cells as a Viable Solution for the Storage and Distribution of Cell Therapy Products

  • André Branco,
  • Ana L. Tiago,
  • Paula Laranjeira,
  • Maria C. Carreira,
  • João C. Milhano,
  • Francisco dos Santos,
  • Joaquim M. S. Cabral,
  • Artur Paiva,
  • Cláudia L. da Silva and
  • Ana Fernandes-Platzgummer

Cell and gene therapies (CGT) have reached new therapeutic targets but have noticeably high prices. Solutions to reduce production costs might be found in CGT storage and transportation since they typically involve cryopreservation, which is a heavil...

  • Article
  • Open Access
8 Citations
2,863 Views
17 Pages

Automatic pain estimation plays an important role in the field of medicine and health. In the previous studies, most of the entire image frame was directly imported into the model. This operation can allow background differences to negatively affect...

  • Article
  • Open Access
8 Citations
2,973 Views
12 Pages

A Highly Sensitive Urinary Exosomal miRNAs Biosensor Applied to Evaluation of Prostate Cancer Progression

  • Yueh-Er Chiou,
  • Kai-Jie Yu,
  • Sow-Neng Pang,
  • Yan-Lin Yang,
  • See-Tong Pang and
  • Wen-Hui Weng

Prostate cancer is the most common cancer in the male population, carrying a significant disease burden. PSA is a widely available screening tools for this disease. Current screen-printed carbon electrode (SPCE)-based biosensors use a two-pronged pro...

  • Article
  • Open Access
6 Citations
5,646 Views
20 Pages

The waveform of chest compressions directly affects the blood circulation of patients with cardiac arrest. Currently, few pieces of research have focused on the influence of the cardiopulmonary resuscitation (CPR) device’s mechanical waveform o...

  • Article
  • Open Access
2 Citations
3,066 Views
14 Pages

Effect of Hypoxia on Branching Characteristics and Cell Subpopulations during Kidney Organ Culture

  • Morgan Hamon,
  • Hsiao-Min Cheng,
  • Ming Johnson,
  • Norimoto Yanagawa and
  • Peter V. Hauser

During early developmental stages, embryonic kidneys are not fully vascularized and are potentially exposed to hypoxic conditions, which is known to influence cell proliferation and survival, ureteric bud branching, and vascularization of the develop...

  • Article
  • Open Access
2,851 Views
13 Pages

Even though non-steroidal anti-inflammatory drugs are the most effective treatment for inflammatory conditions, they have been linked to negative side effects. A promising approach to mitigating potential risks, is the development of new compounds ab...

  • Article
  • Open Access
9 Citations
4,341 Views
10 Pages

Acid attacks are on the rise, and they cause extensive and deep burns, especially on the face. The treatments used to improve the aesthetic, functional and social impact of non-acid scars do not always prove useful for acid scars. This article report...

  • Article
  • Open Access
11 Citations
3,491 Views
23 Pages

The Effect of Cultivation Conditions on Antifungal and Maize Seed Germination Activity of Bacillus-Based Biocontrol Agent

  • Vanja Vlajkov,
  • Ivana Pajčin,
  • Marta Loc,
  • Dragana Budakov,
  • Jelena Dodić,
  • Mila Grahovac and
  • Jovana Grahovac

Aflatoxin contamination is a global risk and a concerning problem threatening food safety. The biotechnological answer lies in the production of biocontrol agents that are effective against aflatoxins producers. In addition to their biocontrol effect...

  • Review
  • Open Access
13 Citations
4,848 Views
21 Pages

Epigenetics and Gut Microbiota Crosstalk: A potential Factor in Pathogenesis of Cardiovascular Disorders

  • Vineet Mehta,
  • Priyanka Nagu,
  • Baskaran Stephen Inbaraj,
  • Minaxi Sharma,
  • Arun Parashar and
  • Kandi Sridhar

Cardiovascular diseases (CVD) are the leading cause of mortality, morbidity, and “sudden death” globally. Environmental and lifestyle factors play important roles in CVD susceptibility, but the link between environmental factors and genet...

  • Review
  • Open Access
13 Citations
7,496 Views
14 Pages

Bioengineering Liver Organoids for Diseases Modelling and Transplantation

  • Junzhi Li,
  • Jing Chu,
  • Vincent Chi Hang Lui,
  • Shangsi Chen,
  • Yan Chen and
  • Paul Kwong Hang Tam

Organoids as three-dimension (3D) cellular organizations partially mimic the physiological functions and micro-architecture of native tissues and organs, holding great potential for clinical applications. Advances in the identification of essential f...

  • Article
  • Open Access
17 Citations
3,909 Views
14 Pages

Engineering Human Mesenchymal Bodies in a Novel 3D-Printed Microchannel Bioreactor for Extracellular Vesicle Biogenesis

  • Richard Jeske,
  • Xingchi Chen,
  • Logan Mulderrig,
  • Chang Liu,
  • Wenhao Cheng,
  • Olivia Z. Zeng,
  • Changchun Zeng,
  • Jingjiao Guan,
  • Daniel Hallinan and
  • Yan Li
  • + 1 author

Human Mesenchymal Stem Cells (hMSCs) and their derived products hold potential in tissue engineering and as therapeutics in a wide range of diseases. hMSCs possess the ability to aggregate into “spheroids”, which has been used as a precon...

  • Article
  • Open Access
14 Citations
3,390 Views
15 Pages

There are several alternative technologies to nitrite use in meat products, including cold plasma. In this study, a cold-plasma-treated phosphate solution was added to smoked sausage, as a new ingredient. Subsequently, the color, texture, and flavor...

  • Article
  • Open Access
30 Citations
4,416 Views
17 Pages

A Novel Smart Belt for Anxiety Detection, Classification, and Reduction Using IIoMT on Students’ Cardiac Signal and MSY

  • Rishi Pal,
  • Deepak Adhikari,
  • Md Belal Bin Heyat,
  • Bishal Guragai,
  • Vivian Lipari,
  • Julien Brito Ballester,
  • Isabel De la Torre Díez,
  • Zia Abbas and
  • Dakun Lai

The prevalence of anxiety among university students is increasing, resulting in the negative impact on their academic and social (behavioral and emotional) development. In order for students to have competitive academic performance, the cognitive fun...

  • Article
  • Open Access
7 Citations
4,051 Views
15 Pages

A 3D tumor spheroid has been increasingly applied in pharmaceutical development for its simulation of the tumor structure and microenvironment. The embedded-culture of a tumor spheroid within a hydrogel microenvironment could help to improve the mimi...

  • Review
  • Open Access
5 Citations
6,756 Views
23 Pages

Bioprocess Economic Modeling: Decision Support Tools for the Development of Stem Cell Therapy Products

  • William O. S. Salvador,
  • Inês A. B. Ribeiro,
  • Diogo E. S. Nogueira,
  • Frederico C. Ferreira,
  • Joaquim M. S. Cabral and
  • Carlos A. V. Rodrigues

Over recent years, the field of cell and gene therapy has witnessed rapid growth due to the demonstrated benefits of using living cells as therapeutic agents in a broad range of clinical studies and trials. Bioprocess economic models (BEMs) are funda...

  • Systematic Review
  • Open Access
9 Citations
6,448 Views
24 Pages

Effectiveness of Mechanical Horse-Riding Simulator-Based Interventions in Patients with Cerebral Palsy—A Systematic Review and Meta-Analysis

  • Esteban Obrero-Gaitán,
  • Desirée Montoro-Cárdenas,
  • Irene Cortés-Pérez and
  • María Catalina Osuna-Pérez

Background: Mechanical horse-riding simulator (HRS) exercises are a type of therapy based on the use of robotic or mechanical devices that produces movement similar to a real horse with the aim of simulating hippotherapy. This review analyses the eff...

  • Article
  • Open Access
16 Citations
4,131 Views
15 Pages

Compressive Mechanical Behavior of Partially Oxidized Polyvinyl Alcohol Hydrogels for Cartilage Tissue Repair

  • Silvia Todros,
  • Silvia Spadoni,
  • Silvia Barbon,
  • Elena Stocco,
  • Marta Confalonieri,
  • Andrea Porzionato and
  • Piero Giovanni Pavan

Polyvinyl alcohol (PVA) hydrogels are extensively used as scaffolds for tissue engineering, although their biodegradation properties have not been optimized yet. To overcome this limitation, partially oxidized PVA has been developed by means of diffe...

  • Article
  • Open Access
1 Citations
3,643 Views
14 Pages

Investigation on Enamel and Dentine of Tooth through 1D Photonic Structure to Identify the Caries in Human Teeth

  • Mohammad Khursheed Alam,
  • Vigneswaran Dhasarathan,
  • Moustafa H. Aly,
  • Mahmud Uz Zaman,
  • Kiran Kumar Ganji,
  • Rehana Basri,
  • Manay Srinivas Munisekhar and
  • Anil Kumar Nagarajappa

In this research, a one-dimensional (1D) photonic structure was employed to study the nature of both enamel and dentine teeth at the signal of 1.8 THz. A simple three layer one-dimensional crystal is chosen to avoid fabrication intricacy. The materia...

  • Review
  • Open Access
27 Citations
9,051 Views
16 Pages

Bioprocessing by Decellularized Scaffold Biomaterials in Cultured Meat: A Review

  • Hongyun Lu,
  • Keqin Ying,
  • Ying Shi,
  • Donghong Liu and
  • Qihe Chen

As novel carrier biomaterials, decellularized scaffolds have promising potential in the development of cellular agriculture and edible cell-cultured meat applications. Decellularized scaffold biomaterials have characteristics of high biocompatibility...

  • Article
  • Open Access
5 Citations
2,938 Views
17 Pages

A polyacrylamide polysaccharide hydrogel (PASG) containing a nonionic surfactant of the polyoxyethylene nonylphenyl ethers series (NP14) has been adapted to the fabrication of a reusable cost-effective ultrasonic tissue-mimicking phantom for real-tim...

  • Article
  • Open Access
23 Citations
4,140 Views
17 Pages

In the present study, we have analyzed the mechanical characteristics and bioactivity of titanium coating with hydroxyapatite/bovine collagen. Hydroxyapatite (HAp) was synthesized from a Pinctada maxima shell and has a stoichiometry (Ca/P) of 1.72 an...

  • Article
  • Open Access
67 Citations
7,038 Views
16 Pages

A Deep Learning Approach for Detecting Stroke from Brain CT Images Using OzNet

  • Oznur Ozaltin,
  • Orhan Coskun,
  • Ozgur Yeniay and
  • Abdulhamit Subasi

A brain stroke is a life-threatening medical disorder caused by the inadequate blood supply to the brain. After the stroke, the damaged area of the brain will not operate normally. As a result, early detection is crucial for more effective therapy. C...

  • Review
  • Open Access
57 Citations
11,940 Views
35 Pages

Electroencephalography (EEG) is a complicated, non-stationary signal that requires extensive preprocessing and feature extraction approaches to be accurately analyzed. In recent times, Deep learning (DL) has shown great promise in exploiting the char...

  • Article
  • Open Access
1 Citations
2,769 Views
13 Pages

About 3D Printability of Thermoplastic Collagen for Biomedical Applications

  • Marina Passos,
  • Sergej Zankovic,
  • Graça Minas,
  • Enno Klüver,
  • Marit Baltzer,
  • Hagen Schmal and
  • Michael Seidenstuecker

With more than 1.5 million total knee and hip implants placed each year, there is an urgent need for a drug delivery system that can effectively support the repair of bone infections. Scaffolds made of natural biopolymers are widely used for this pur...

  • Article
  • Open Access
21 Citations
5,857 Views
18 Pages

Phyto-Synthesis, Characterization, and In Vitro Antibacterial Activity of Silver Nanoparticles Using Various Plant Extracts

  • Bilal Ahmad,
  • Li Chang,
  • Usama Qamar Satti,
  • Sami ur Rehman,
  • Huma Arshad,
  • Ghazala Mustafa,
  • Uzma Shaukat,
  • Fenghua Wang and
  • Chunyi Tong

Aloe vera, Mentha arvensis (mint), Coriandrum sativum (coriander), and Cymbopogon citratus (lemongrass) leaf extracts were used to synthesize stable silver nanoparticles (Ag-NPs) by green chemistry. UV–vis spectrophotometry, X-ray diffraction (XRD),...

  • Article
  • Open Access
2 Citations
3,039 Views
13 Pages

Upgrading of Biobased Glycerol to Glycerol Carbonate as a Tool to Reduce the CO2 Emissions of the Biodiesel Fuel Life Cycle

  • Biagio Anderlini,
  • Alberto Ughetti,
  • Emma Cristoni,
  • Luca Forti,
  • Luca Rigamonti and
  • Fabrizio Roncaglia

With regards to oil-based diesel fuel, the adoption of bio-derived diesel fuel was estimated to reduce CO2 emissions by approximately 75%, considering the whole life cycle. In this paper, we present a novel continuous-flow process able to transfer an...

  • Article
  • Open Access
21 Citations
3,949 Views
16 Pages

A High-Accuracy Detection System: Based on Transfer Learning for Apical Lesions on Periapical Radiograph

  • Yueh Chuo,
  • Wen-Ming Lin,
  • Tsung-Yi Chen,
  • Mei-Ling Chan,
  • Yu-Sung Chang,
  • Yan-Ru Lin,
  • Yuan-Jin Lin,
  • Yu-Han Shao,
  • Chiung-An Chen and
  • Patricia Angela R. Abu
  • + 1 author

Apical Lesions, one of the most common oral diseases, can be effectively detected in daily dental examinations by a periapical radiograph (PA). In the current popular endodontic treatment, most dentists spend a lot of time manually marking the lesion...

  • Review
  • Open Access
10 Citations
3,411 Views
21 Pages

Anti-Tumor Secondary Metabolites Originating from Fungi in the South China Sea’s Mangrove Ecosystem

  • Yuyou Luo,
  • Xiongming Luo,
  • Tong Zhang,
  • Siyuan Li,
  • Shuping Liu,
  • Yuxin Ma,
  • Zongming Wang,
  • Xiaobao Jin,
  • Jing Liu and
  • Xin Wang

A mangrove is a unique ecosystem with abundant resources, in which fungi are an indispensable microbial part. Numerous mangrove fungi-derived secondary metabolites are considerable sources of novel bioactive substances, such as polyketides, terpenoid...

  • Article
  • Open Access
6 Citations
3,171 Views
18 Pages

Accurate Image Reconstruction in Dual-Energy CT with Limited-Angular-Range Data Using a Two-Step Method

  • Buxin Chen,
  • Zheng Zhang,
  • Dan Xia,
  • Emil Y. Sidky,
  • Taly Gilat-Schmidt and
  • Xiaochuan Pan

Dual-energy CT (DECT) with scans over limited-angular ranges (LARs) may allow reductions in scan time and radiation dose and avoidance of possible collision between the moving parts of a scanner and the imaged object. The beam-hardening (BH) and LAR...

  • Review
  • Open Access
16 Citations
7,551 Views
11 Pages

Licensed glycoconjugate vaccines are generally prepared using native or sized polysaccharides coupled to a carrier protein through random linkages along the polysaccharide chain. These polysaccharides must be chemically modified before covalent linki...

  • Article
  • Open Access
8 Citations
3,105 Views
20 Pages

Automation of Measurements for Personalized Medical Appliances by Means of CAD Software—Application in Robin Sequence Orthodontic Appliances

  • Maite Aretxabaleta,
  • Ariadne Roehler,
  • Christian F. Poets,
  • Alexander B. Xepapadeas,
  • Bernd Koos and
  • Christina Weise

Measuring the dimensions of personalized devices can provide relevant information for the production of future such devices used in various medical specialties. Difficulties with standardizing such measurement and obtaining high accuracy, alongside c...

  • Article
  • Open Access
5 Citations
3,505 Views
11 Pages

Fatty acid composition has an important influence on the fluidity of biological membranes, which is a key factor for the survival of Escherichia coli. With the aim to modify fatty acid composition in this experimentally friendly microorganism, the At...

of 3

XFacebookLinkedIn
Bioengineering - ISSN 2306-5354