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Antibiotics, Volume 14, Issue 7

July 2025 - 110 articles

Cover Story: Platelet concentrates (PCs), used to treat patients with bleeding disorders, are stored at 20–24 °C to maintaining platelet functionality. These conditions also sustain the growth of bacteria such as Staphylococcus aureus, which poses an important safety risk to transfusion patients as it reaches clinically significant levels and produces virulence factors during PC storage. Previous studies have demonstrated that Staphylococcus spp. grown in PCs display upregulation of genes encoding for antimicrobial resistance and virulence. To expand the current knowledge, this study aimed to test whether the increase in the norB efflux pump expression observed in PCs translates into heightened quinolone resistance. Furthermore, the role of the NorB efflux pump on S. aureus virulence was investigated using a Bombyx mori (silkworm) animal model. View this paper
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Articles (110)

  • Article
  • Open Access
2,697 Views
21 Pages

Trends in Positive Urine Culture Rates and Antimicrobial Resistance in Non-Hospitalized Children from Western Romania: A Retrospective Observational Study

  • Constantin Catalin Marc,
  • Maria Daniela Mot,
  • Monica Licker,
  • Delia Muntean,
  • Daniela Teodora Marti,
  • Ana Alexandra Ardelean,
  • Alina Ciceu,
  • Sergiu Adrian Sprintar,
  • Daniela Adriana Oatis and
  • Alin Gabriel Mihu
  • + 1 author

Background: Urinary tract infections (UTIs) are among the most common types of infections during childhood. Limited data are available on the prevalence of UTI in children from Romania, with most being available for hospitalized children. For this re...

  • Article
  • Open Access
1,310 Views
9 Pages

Should Cefoxitin Non-Susceptibility in Ceftriaxone-Susceptible E. coli and K. pneumoniae Prompt Concerns Regarding Plasmid-Mediated AmpC Resistance? A Genomic Characterization and Summary of Treatment Challenges in Singapore

  • Jonathan Jinpeng Foo,
  • Ying Ying Ong,
  • Clement Kin Ming Tsui,
  • David C. Lye,
  • De Partha Pratim,
  • Nurhidayah Binte Mohamed Yazid,
  • Swaine L. Chen,
  • Shawn Vasoo and
  • Tat Ming Ng

Objectives: Plasmid-mediated AmpC beta-lactamases represent a growing clinical concern in Enterobacterales, with challenges in diagnostic approaches, limited data on clinical outcomes, and our incomplete understanding of their regulatory mechanisms w...

  • Article
  • Open Access
1,087 Views
13 Pages

Multisite Infections Caused by Carbapenem-Resistant Klebsiella Pneumoniae: Unveiling the Clinical Characteristics and Risk Factors

  • Jing Li,
  • Shunjun Wu,
  • Huanhuan Zhang,
  • Xingxing Guo,
  • Wanting Meng,
  • Heng Zhao and
  • Liqiang Song

Objectives: There is a scarcity of studies on multisite infections (MSIs) caused by carbapenem-resistant Klebsiella pneumoniae (CRKP). The primary objectives of this research were to determine the clinical characteristics of CRKP MSI, and the risk fa...

  • Review
  • Open Access
1 Citations
1,933 Views
21 Pages

Veterinary Clinics as Reservoirs for Pseudomonas aeruginosa: A Neglected Pathway in One Health Surveillance

  • George Cosmin Nadăş,
  • Alice Mathilde Manchon,
  • Cosmina Maria Bouari and
  • Nicodim Iosif Fiț

Pseudomonas aeruginosa is a highly adaptable opportunistic pathogen with significant clinical relevance in both human and veterinary medicine. Despite its well-documented role in hospital-acquired infections in human healthcare settings, its persiste...

  • Article
  • Open Access
1,187 Views
13 Pages

Extended-Spectrum Beta-Lactamase Production and Carbapenem Resistance in Elderly Urinary Tract Infection Patients: A Multicenter Retrospective Study from Turkey

  • Çiğdem Yıldırım,
  • Sema Sarı,
  • Ayşe Merve Parmaksızoğlu Aydın,
  • Aysin Kilinç Toker,
  • Ayşe Turunç Özdemir,
  • Esra Erdem Kıvrak,
  • Sinan Mermer,
  • Hasip Kahraman,
  • Orçun Soysal and
  • Hasan Çağrı Yıldırım
  • + 1 author

Introduction: Urinary tract infections (UTIs) remain a significant public health issue worldwide, particularly affecting the geriatric population with increased morbidity and mortality. Aging-related immune changes, comorbidities, and urogenital abno...

  • Review
  • Open Access
3 Citations
3,676 Views
32 Pages

Fungal Biofilm: An Overview of the Latest Nano-Strategies

  • Andrea Giammarino,
  • Laura Verdolini,
  • Giovanna Simonetti and
  • Letizia Angiolella

Background/Objectives: There is an increasing incidence of fungal infections in conjunction with the rise in resistance to medical treatment. Antimicrobial resistance is frequently associated with virulence factors such as adherence and the capacity...

  • Article
  • Open Access
1,261 Views
15 Pages

High Prevalence of Multidrug-Resistant Bacterial Colonization Among Patients and Healthcare Workers in a Rural Ethiopian Hospital

  • Elena Hidalgo,
  • Teresa Alvaredo-Carrillo,
  • Josefina-Marina Gil-Belda,
  • Clara Portela-Pino,
  • Clara Bares-Moreno,
  • Sara Jareño-Moreno,
  • Paula de la Fuente,
  • Lucía Platero and
  • Ramón Pérez-Tanoira

Background/Objectives: Multidrug-resistant (MDR) bacterial colonization poses a significant risk for subsequent infections, especially within hospital environments. Healthcare workers can inadvertently transmit these MDR bacteria to vulnerable patien...

  • Article
  • Open Access
1 Citations
2,146 Views
11 Pages

Effects of Antibiotic De-Escalation on Outcomes in Severe Community-Acquired Pneumonia: An Inverse Propensity Score-Weighted Analysis

  • Diego Viasus,
  • Gabriela Abelenda-Alonso,
  • Juan Bolivar-Areiza,
  • Carlota Gudiol and
  • Jordi Carratalà

Objective: This study aimed to assess the effect of antibiotic de-escalation on 30-day mortality, duration of intravenous (IV) antibiotic therapy and length of hospital stay (LOS) in severe community-acquired pneumonia (sCAP). Methods: We performed a...

  • Article
  • Open Access
1 Citations
781 Views
11 Pages

Antimicrobial Behavior of Surface-Treated Commercially Pure Titanium (CpTi) for Dental Implants in Artificial Saliva—In Vitro Study

  • Roshni Bopanna,
  • Neetha J. Shetty,
  • Ashith M. Varadaraj,
  • Himani Kotian,
  • Sameep Shetty and
  • Simran Genescia

Background/Objectives:Titanium implant surface modifications enhance osseointegration and prevent microbial colonization, improving implant longevity. Antimicrobial coatings, particularly cerium- and bismuth-doped hydroxyapatite (CeHAp and BiHAp), ha...

  • Article
  • Open Access
1,043 Views
11 Pages

Background/Objectives: Antibiotic resistance presents an urgent public health threat. By developing a streamlined and effective method for studying bacteriophage induction, this research marks a step further in understanding how antibiotic-resistant...

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Antibiotics - ISSN 2079-6382