Methods for Preventing Biofilm Formation and Treat the Infections Caused by Biofilm Formed on Biotics or Abiotic Surfaces

Dear Colleagues,

Biofilms are complex structures formed by communities of microorganisms adhered to a biotic or abiotic surface surrounded by an extracellular matrix consisting of polysaccharides, proteins and extracellular DNA. In biofilm form, microorganisms are less sensitive to antibiotics than in planktonic form. Variations in the concentration of antibiotics throughout a biofilm cause the exposure of microbial cells to levels below inhibitory concentrations, and this can cause resistance in microorganisms. To avoid infections, the ideal is to promote the removal of biofilm daily. However, when there is an established infection, the ideal would be to disorganize the biofilm so that the antibiotic can reach microbial cells in the necessary concentration. Thus, the objective is to compile a Special Edition with studies that propose methods for preventing the formation of biofilm and/or that promote the disruption of the biofilm concomitant with the application of an antibiotic for the treatment of infections.

Prof. Dr. Cláudia Helena Silva-Lovato
Dr. Adriana Barbosa Ribeiro
Guest Editors

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