Epidemiological Data on Antibiotic Resistance
A special issue of Antibiotics (ISSN 2079-6382). This special issue belongs to the section "Mechanism and Evolution of Antibiotic Resistance".
Deadline for manuscript submissions: 30 November 2024 | Viewed by 3284
Special Issue Editor
Interests: bacterial zoonoses; clinical microbiology; epidemiology; Francisella tularensis
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Antibiotic resistance is a major threat to human health and a worldwide public health priority. Almost all bacterial species causing human infections have developed resistance to one or several antibiotic classes. Antibiotic resistance mechanisms are complex and associated with phenotypic and genetic changes. In addition to the classical resistance mechanisms (i.e., modification of the antibiotic bacterial targets, inactivation of the antibiotic, reduction in antibiotic penetration, and antibiotic efflux), bacteria can develop many other resistance pathways (including metabolism reduction, persisters, and other physiological changes). Understanding the evolutionary mechanisms leading to these resistances remains a challenge. Experimental models have allowed researchers to address several issues, including the speed, frequency, reproducibility, and conditions of resistance selection as well as the phenotypic and genetic changes, molecular mechanisms, evolution pathways, and fitness costs associated with antibiotic resistance. Strategies to combat antibiotic resistance have also been evaluated experimentally, and include preventing or delaying evolution to antibiotic resistance, reverting antibiotic resistance to susceptibility, restoring antibiotic-susceptible populations, and increasing the bacterial fitness cost of antibiotic resistance. The Special Issue focuses on all these aspects of experimental evaluation of bacterial evolution to antibiotic resistance using axenic media, cell cultures, or animal models.
Dr. Max Maurin
Guest Editor
Manuscript Submission Information
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Keywords
- antibiotic resistance
- experimental models
- antibiotic resistance selection
- antibiotic resistance evolution pathways
- antibiotic resistance phenotypes
- antibiotic resistance genotypes
- antibiotic resistance mechanisms
- antibiotic resistance cost
- antibiotic resistance prevention and control
- antibiotic resistance reversion
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