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Antibiotics
Special Issues
Veterinary Microbiology and Antimicrobial Resistance—the One Health Approach
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Veterinary Microbiology and Antimicrobial Resistance—the One Health Approach

A special issue of Antibiotics (ISSN 2079-6382). This special issue belongs to the section "Antibiotics in Animal Health".

Deadline for manuscript submissions: 15 October 2025 | Viewed by 2673

Special Issue Editor

Prof. Dr. George Cosmin Nadǎş

E-Mail Website
Guest Editor
Faculty of Veterinary Medicine, UASVM Cluj-Napoca, Cluj-Napoca, Romania
Interests: antimicrobial susceptibility testing; plant extracts bioactivity; antimicrobial activity of nanoparticles and yeast identification

Special Issue Information

Dear Colleagues,

This Special Issue, titled Veterinary Microbiology and Antimicrobial Resistance—the One Health Approach, will highlight the critical intersection between animal, human, and environmental health in combating the growing threat of antimicrobial resistance (AMR). The One Health framework recognizes that the health of all living organisms and their shared environment is interconnected, so tackling AMR requires a collaborative, multidisciplinary approach. This Special Issue brings together cutting-edge research on veterinary microbiology, focusing on the role of animals as reservoirs and vectors for resistant pathogens that can affect both animal and human populations. It explores mechanisms of antimicrobial resistance in veterinary settings, the impact on animal health, and the broader implications for public health. Contributions will also delve into innovative strategies for monitoring, controlling, and mitigating AMR, including policy frameworks, novel treatments, and sustainable practices. By advancing our understanding of how resistance develops and spreads across species, this Special Issue will foster global cooperation for addressing AMR as a shared challenge, ensuring safer and healthier ecosystems for all.

Prof. Dr. George Cosmin Nadǎş
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antibiotics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • antimicrobial resistance
  • veterinary microbiology
  • MDR
  • one health
  • zoonotic

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (3 papers)

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Research

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19 pages, 1281 KiB  
Article
Phenotypic and Genotypic Characterization of ESBL and AmpC β-Lactamase-Producing E. coli Isolates from Poultry in Northwestern Romania
by Anca Rus, Iulia-Maria Bucur, Kalman Imre, Andreea Talida Tirziu, Andrei Alexandru Ivan, Radu Valentin Gros, Alex Cristian Moza, Sebastian Alexandru Popa, Alexandra Ban-Cucerzan and Emil Tirziu
Antibiotics 2025, 14(6), 578; https://doi.org/10.3390/antibiotics14060578 - 5 Jun 2025
Viewed by 639
Abstract
Background/Objectives: The widespread use of antibiotics in animal husbandry has led to an increase in antimicrobial-resistant Escherichia coli, particularly strains producing extended-spectrum β-lactamases (ESBL) and AmpC β-lactamases. This study aimed to isolate and characterize such strains from fecal samples of broiler [...] Read more.
Background/Objectives: The widespread use of antibiotics in animal husbandry has led to an increase in antimicrobial-resistant Escherichia coli, particularly strains producing extended-spectrum β-lactamases (ESBL) and AmpC β-lactamases. This study aimed to isolate and characterize such strains from fecal samples of broiler chickens (n = 71) and slaughtered turkeys (n = 31) in northwestern Romania. Methods: Antimicrobial susceptibility testing and PCR were used to evaluate phenotypic resistance patterns and detect the presence of resistance genes (AmpC, blaZ, and blaTEM). Results: The results showed that 55% of turkey and 61% of broiler isolates were presumptive ESBL/AmpC producers. Among all isolates, 50% were classified as extensively drug-resistant (XDR), 44% as multidrug-resistant (MDR), and only 6% were fully susceptible. Gene detection revealed an overall prevalence of 44.2% for AmpC, 72.7% for blaZ, and 58.1% for blaTEM, yielding a total penetrance of 51.09%. The diagnostic odds ratio (DOR) values, ranging from 0.67 to 81, suggest the efficacy of the antibiotic susceptibility testing method used in detecting the presence of these resistance genes. Conclusion: Overall, these findings highlight a significant burden of antimicrobial-resistant, poultry-associated E. coli strains, warranting stricter antimicrobial stewardship. Full article
(This article belongs to the Special Issue Veterinary Microbiology and Antimicrobial Resistance—the One Health Approach)
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Review

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21 pages, 1088 KiB  
Review
Veterinary Clinics as Reservoirs for Pseudomonas aeruginosa: A Neglected Pathway in One Health Surveillance
by George Cosmin Nadăş, Alice Mathilde Manchon, Cosmina Maria Bouari and Nicodim Iosif Fiț
Antibiotics 2025, 14(7), 720; https://doi.org/10.3390/antibiotics14070720 - 17 Jul 2025
Viewed by 616
Abstract
Pseudomonas aeruginosa is a highly adaptable opportunistic pathogen with significant clinical relevance in both human and veterinary medicine. Despite its well-documented role in hospital-acquired infections in human healthcare settings, its persistence and transmission within veterinary clinics remain underexplored. This review highlights the overlooked [...] Read more.
Pseudomonas aeruginosa is a highly adaptable opportunistic pathogen with significant clinical relevance in both human and veterinary medicine. Despite its well-documented role in hospital-acquired infections in human healthcare settings, its persistence and transmission within veterinary clinics remain underexplored. This review highlights the overlooked status of veterinary facilities as environmental reservoirs and amplification points for multidrug-resistant (MDR) P. aeruginosa, emphasizing their relevance to One Health surveillance. We examine the bacterium’s environmental survival strategies, including biofilm formation, resistance to disinfectants, and tolerance to nutrient-poor conditions that facilitate the long-term colonization of moist surfaces, drains, medical equipment, and plumbing systems. Common transmission vectors are identified, including asymptomatic animal carriers, contaminated instruments, and the hands of veterinary staff. The review synthesizes current data on antimicrobial resistance in environmental isolates, revealing frequent expression of efflux pumps and mobile resistance genes, and documents the potential for zoonotic transmission to staff and pet owners. Key gaps in environmental monitoring, infection control protocols, and genomic surveillance are identified, with a call for standardized approaches tailored to the veterinary context. Control strategies, including mechanical biofilm disruption, disinfectant cycling, effluent monitoring, and staff hygiene training, are evaluated for feasibility and impact. The article concludes with a One Health framework outlining cross-species and environmental transmission pathways. It advocates for harmonized surveillance, infrastructure improvements, and intersectoral collaboration to reduce the risk posed by MDR P. aeruginosa within veterinary clinical environments and beyond. By addressing these blind spots, veterinary facilities can become proactive partners in antimicrobial stewardship and global resistance mitigation. Full article
(This article belongs to the Special Issue Veterinary Microbiology and Antimicrobial Resistance—the One Health Approach)
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Other

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11 pages, 1483 KiB  
Case Report
First Report of Respiratory Infection Caused by Multidrug-Resistant Escherichia coli in an Ostrich in Romania
by Vlad Iorgoni, Ionica Iancu, Ionela Popa, Alexandru Gligor, Gabriel Orghici, Bogdan Sicoe, Cristian Dreghiciu, David Purec, Paula Nistor, Bogdan Florea and Viorel Herman
Antibiotics 2025, 14(4), 354; https://doi.org/10.3390/antibiotics14040354 - 31 Mar 2025
Cited by 3 | Viewed by 919
Abstract
Introduction: Ostrich farming is increasingly recognized for its economic potential but poses significant health challenges due to the risk of pathogen transmission, including multidrug-resistant Escherichia coli. Case study: This study reports a case of a four-month-old female ostrich from western Romania presenting [...] Read more.
Introduction: Ostrich farming is increasingly recognized for its economic potential but poses significant health challenges due to the risk of pathogen transmission, including multidrug-resistant Escherichia coli. Case study: This study reports a case of a four-month-old female ostrich from western Romania presenting with severe respiratory and digestive infections, progressing to septicemia and death. A post-mortem examination revealed extensive mucus in the trachea, pulmonary congestion, hemorrhagic enteritis, and approximately 1250 g of metal objects in the ventriculus. Pure cultures of E. coli were isolated from the lungs and bone marrow and identified via MALDI-TOF MS. The strain exhibited multidrug resistance to several antibiotics, including enrofloxacin, doxycycline, and amoxicillin, highlighting the critical issue of antimicrobial resistance in veterinary medicine. Discussions: This case underscores the need for enhanced management practices in ostrich farming to mitigate environmental and pathogenic risks, as well as the urgency of developing alternative strategies for controlling resistant bacterial infections in avian species. Conclusions: This case highlights the need for alternative treatments and stricter antimicrobial stewardship to combat multidrug-resistant E. coli in ostriches. Full article
(This article belongs to the Special Issue Veterinary Microbiology and Antimicrobial Resistance—the One Health Approach)
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