Genomic Analysis of Antimicrobial Drug-Resistant Bacteria

Dear Colleagues,

Antimicrobial drug resistance has become one of the major threats to global health. The emergence of multidrug-resistant (MDR) Gram-negative and Gram-positive bacteria challenges the treatments available in medicine, putting the lives of infected patients at risk. The affordability of whole-genome sequencing (WGS), together with the availability of easily applicable bioinformatic tools for genomic analyses, can provide a wealth of information about any microorganism. With regard to MDR pathogenic bacteria, genome sequence analysis allows for (i) strain identification and typing; (ii) detection of antimicrobial resistance genes; (iii) recognition of mobile genetic elements involved in the capture, maintenance and dissemination of those genes, such as genomic islands, plasmids, transposons, insertion sequences and integrons; (iv) unveiling phylogenetic relationships and evolutionary pathways; and (v) disclosing the emergence of new high-risk clones of bacterial pathogens, driven by their resistance, virulence and fitness properties which allow for adaptation to an ever-changing environment. This Special Issue invites original research articles, communications and reviews fitting into these topics and centered in any bacteria which may contribute to the spread of antimicrobial drug resistance within the One Health concept. We look forward to receiving your contributions.

Prof. Dr. Maria Rosario Rodicio
Dr. Carlos Rodriguez-Lucas
Guest Editors

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