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Journal of Functional Biomaterials, Volume 16, Issue 12

December 2025 - 45 articles

Cover Story: 3D bioprinting offers a unique opportunity to fabricate tissues with complex, spatially controlled functionality that closely resembles native tissues. Articular cartilage is a clear example, as its zonal organization has marked variations in composition, cell density, and mechanical properties through its thickness—features absent in conventional homogeneous scaffolds. By enabling precise control over material deposition and crosslinking, 3D bioprinting allows the generation of stiffness gradients to reproduce, to a certain extent, the native environment, guiding cell distribution and matrix deposition in a spatially regulated manner. Our findings highlight how advanced 3D bioprinting strategies can move tissue engineering beyond uniform designs toward biomimetic scaffolds with enhanced mechano-functional relevance. View this paper
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Articles (45)

  • Article
  • Open Access
333 Views
15 Pages

Does Printing Orientation Matter in PolyJet 3D Printed Teeth for Endodontics? A Micro-CT Analysis

  • Cláudia Barbosa,
  • Tiago Reis,
  • José B. Reis,
  • Margarida Franco,
  • Catarina Batista,
  • Rui B. Ruben,
  • Benjamín Martín-Biedma and
  • Jose Martín-Cruces

18 December 2025

This study aimed to identify the optimal printing orientation (X, Y, or Z axis) and positioning of a mandibular molar presenting an isthmus using PolyJet™ technology. The influence of these parameters on dimensional accuracy and on the behavior...

  • Article
  • Open Access
351 Views
15 Pages

Sodium Hypochlorite/Amino Acid Gel in the Non-Surgical Treatment of Periodontitis—Clinical and Molecular Results of Randomized Clinical Trial

  • Ewa Dolińska,
  • Katarzyna Golińska,
  • Violetta Dymicka-Piekarska,
  • Robert Milewski,
  • Magdalena Sulewska and
  • Małgorzata Pietruska

18 December 2025

Due to the limitations of SRP, new methods are being sought to support non-surgical periodontal therapy. One of them is the use of antiseptics such as low-concentration sodium hypochlorite gel buffered with amino acids (NaOCl/AA). The aim of the stud...

  • Article
  • Open Access
335 Views
20 Pages

Neo-Dermis Formation and Graft Timing After ADM Reconstruction: A Cohort Study with Histological Validation

  • Daniel Pit,
  • Teodora Hoinoiu,
  • Bogdan Hoinoiu,
  • Cristian Suciu,
  • Panche Taskov,
  • Zorin Petrisor Crainiceanu,
  • Daciana Grujic,
  • Isabela Caizer-Gaitan,
  • Miruna Samfireag and
  • Oana Suciu
  • + 1 author

18 December 2025

Acellular dermal matrices (ADMs) are widely used in soft-tissue reconstruction, yet the optimal timing for split-thickness skin grafting (STSG) remains unsettled. We conducted a single-center retrospective cohort study (January 2023–August 2025...

  • Article
  • Open Access
411 Views
16 Pages

Flexural Strength and Hardness Analysis of 3D-Printed vs. Milled Resin Composites Indicated for Definitive Crowns

  • Hunaida Khaled Tayeb,
  • Nick Silikas,
  • Abdulrahman Jafar Alhaddad and
  • Julian Satterthwaite

18 December 2025

The growing use of 3D-printed dental restorations has created a need to understand how the mechanical behaviour of definitive 3D-printed resin composites compares with milled counterparts. This study compared the mechanical properties of 3D-printed a...

  • Article
  • Open Access
320 Views
14 Pages

Split Crest—Is It Necessary to Fill the Gap?—A Controlled Trial

  • Vladimir Biocanin,
  • Zoran Tambur,
  • Djordje Pejanovic,
  • Marija Biocanin,
  • Mihailo Ostojic,
  • Marija Lalovic and
  • Svetislav Zaric

18 December 2025

Introduction: The split crest (SC) is a technique for horizontal ridge augmentation that enables simultaneous implant placement. While the use of bone grafts within the osteotomy gap is well-documented, the efficacy of dentin as a graft material in S...

  • Article
  • Open Access
305 Views
17 Pages

L-Serine–Incorporated Collagen Scaffolds for Modulating In Vivo Degradation Behavior

  • Su-Young Kim,
  • Ji-Hyeon Oh,
  • Min-Ho Hong,
  • Joon Ha Lee,
  • You-Young Jo and
  • Seong-Gon Kim

18 December 2025

Collagen-based biomaterials are widely used, but their relatively rapid biodegradation can limit functional duration. Such collagen constructs are widely used as barrier membranes in guided tissue and bone regeneration, where controlled degradation i...

  • Article
  • Open Access
268 Views
15 Pages

The Carbon Dots from Seabuckthorn (Hippophae rhamnoides L.) Leaves: Recycle the Herbal Waste Products for a Nano-Formulation in Delivering Bioactive Compounds

  • Chen-Xi Xia,
  • Xiong Gao,
  • Queenie Wing-Sze Lai,
  • Zheng-Qi Wang,
  • Lish Sheng-Yin Lin,
  • Janet Yuen-Man Ho,
  • Jia-Yu Zhu,
  • Roy Wai-Lun Tang,
  • Tina Ting-Xia Dong and
  • Karl Wah-Keung Tsim

17 December 2025

Carbon dots have emerged as promising nanocarriers for drug delivery due to their unique physicochemical properties and biocompatibilities. Here, the potential of leaf-derived carbon dots (named as SBLCD), derived from Seabuckthorn (Hippophae rhamnoi...

  • Correction
  • Open Access
162 Views
2 Pages

Correction: Rodrigues et al. Physicochemical, Morphological, and Cytotoxic Properties of Brazilian Jackfruit (Artocarpus heterophyllus) Starch Scaffold Loaded with Silver Nanoparticles. J. Funct. Biomater. 2023, 14, 143

  • José Filipe Bacalhau Rodrigues,
  • Valeriano Soares Azevedo,
  • Rebeca Peixoto Medeiros,
  • Gislaine Bezerra de Carvalho Barreto,
  • Maria Roberta de Oliveira Pinto,
  • Marcus Vinicius Lia Fook and
  • Maziar Montazerian

17 December 2025

In the original publication [...]

  • Article
  • Open Access
1,338 Views
17 Pages

Three-Dimensional Printing of Calcium Phosphate-Mesoporous Bioactive Glass Scaffolds for Bone Tissue Engineering

  • Ana Beatriz Gomes de Carvalho,
  • Lais Medeiros Cardoso,
  • Igor Paulino Mendes Soares,
  • Joyce Rodrigues de Souza,
  • Arpita Roy,
  • Prabaha Sikder,
  • Aldo R. Boccaccini,
  • Eliandra de Sousa Trichês and
  • Marco C. Bottino

16 December 2025

Calcium phosphate cements (CPCs) and biomaterials, such as mesoporous bioactive glass (MBG), are critical for bone tissue engineering. This study aimed to 3D-print CPC scaffolds modified with MBG to enhance their osteogenic potential and regenerative...

  • Article
  • Open Access
347 Views
16 Pages

14 December 2025

Denture base resins are susceptible to microbial colonization, and current antibacterial additives often lose effectiveness and may weaken material properties. This study evaluated whether immersion in a quaternary ammonium methacryloxy silane (QAMS)...

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J. Funct. Biomater. - ISSN 2079-4983