Next Article in Journal
Fracture Load of Polyaryletherketone for 4-Unit Posterior Fixed Dental Prostheses: An In Vitro Study
Previous Article in Journal
Effects of Disinfectant Solutions Against COVID-19 on Surface Roughness, Gloss, and Color of Removable Denture Materials
Previous Article in Special Issue
From Autologous Bone Tissue to Bioengineered Material Solutions in Post-Traumatic Orbital Wall Reconstruction: An Overview
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
JFB
Volume 16
Issue 12
10.3390/jfb16120447
jfb-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
This is an early access version, the complete PDF, HTML, and XML versions will be available soon.
Article

Biomimetic Glycosaminoglycan-Enriched Electrospun Polymeric Scaffolds for Enhanced Early Tissue Regeneration

by
Morgane Meyer
1,2,3,†,
Rana Smaida
1,2,3,†,
Henri Favreau
1,2,3,†,
Cristina Yus
4,5,
Hervé Gegout
1,2,
Manuel Arruebo
4,5,
Nadia Bahlouli
2,
Guy Ladam
6,
Guillaume Conzatti
1,2,3,
Stephan Lemmens
3,
Guoqiang Hua
1,2,3,*,
Florence Fioretti
1,2,* and
Nadia Benkirane-Jessel
1,2,3
1
Institut National de la Santé et de la Recherche Médicale (INSERM) UMR1260, Nanomédicine Régénérative, 1 Rue Eugène Boeckel, 67000 Strasbourg, France
2
Faculté de Pharmacie, Faculté de Chirurgie Dentaire, Faculté de Médecine, Université de Strasbourg, 4 Rue Blaise Pascal, 67000 Strasbourg, France
3
Lamina Therapeutics, 1 Rue Eugène Boeckel, 67000 Strasbourg, France
4
Instituto de Nanociencia y Materiales de Aragón (INMA), CSIC-Universidad de Zaragoza, 50009 Zaragoza, Spain
5
Department of Chemical Engineering, University of Zaragoza, Campus Río Ebro-Edificio I+D, C/ Poeta Mariano Esquillor S/N, 50018 Zaragoza, Spain
6
Normandie Universiy, UNIROUEN, INSA Rouen, CNRS, PBS, 55 rue Saint-Germain, 27000 Évreux, France
*
Authors to whom correspondence should be addressed.
†
These authors contributed equally to this work.
J. Funct. Biomater. 2025, 16(12), 447; https://doi.org/10.3390/jfb16120447 (registering DOI)
Submission received: 28 October 2025 / Revised: 26 November 2025 / Accepted: 28 November 2025 / Published: 29 November 2025
(This article belongs to the Special Issue Materials and Techniques for Bone Tissue Engineering: From Scaffolds to Complex Matrices)
Versions Notes

Abstract

Implantable scaffolds are increasingly recognized as transformative tools in regenerative medicine, offering the potential to prevent or mitigate tissue degeneration. Osteoarthritis is a widespread degenerative joint disease that often progresses from early focal lesions to severe joint damage, creating substantial clinical and socioeconomic burdens. Preventive strategies for early-stage lesions remain limited. This study reports the design and development of a functional polymeric scaffold intended to support early tissue regeneration and potentially prevent lesion progression. The scaffold consists of an electrospun poly (ε-caprolactone) nanofibrous membrane enriched with glycosaminoglycans, including hyaluronic acid and chondroitin sulfate, to mimic essential features of the cartilage extracellular matrix and provide a supportive microenvironment. Complete structural, physicochemical, and mechanical characterization was performed to assess the scaffold architecture, stability, hydration properties, and suitability for tissue environments. In vitro investigations were conducted to evaluate cytocompatibility and the interaction of the scaffold with relevant cell types. The scaffold is designed as a potential future preventive strategy to support cartilage integrity and limit disease progression. This approach represents a promising strategy to preserve joint integrity and function, addressing a critical unmet clinical need and enabling translation toward clinical application.
Keywords: functional polymeric biomaterial; electrospun scaffold; glycosaminoglycans; cell recruitment; cartilage functional polymeric biomaterial; electrospun scaffold; glycosaminoglycans; cell recruitment; cartilage

Share and Cite

MDPI and ACS Style

Meyer, M.; Smaida, R.; Favreau, H.; Yus, C.; Gegout, H.; Arruebo, M.; Bahlouli, N.; Ladam, G.; Conzatti, G.; Lemmens, S.; et al. Biomimetic Glycosaminoglycan-Enriched Electrospun Polymeric Scaffolds for Enhanced Early Tissue Regeneration. J. Funct. Biomater. 2025, 16, 447. https://doi.org/10.3390/jfb16120447

AMA Style

Meyer M, Smaida R, Favreau H, Yus C, Gegout H, Arruebo M, Bahlouli N, Ladam G, Conzatti G, Lemmens S, et al. Biomimetic Glycosaminoglycan-Enriched Electrospun Polymeric Scaffolds for Enhanced Early Tissue Regeneration. Journal of Functional Biomaterials. 2025; 16(12):447. https://doi.org/10.3390/jfb16120447

Chicago/Turabian Style

Meyer, Morgane, Rana Smaida, Henri Favreau, Cristina Yus, Hervé Gegout, Manuel Arruebo, Nadia Bahlouli, Guy Ladam, Guillaume Conzatti, Stephan Lemmens, and et al. 2025. "Biomimetic Glycosaminoglycan-Enriched Electrospun Polymeric Scaffolds for Enhanced Early Tissue Regeneration" Journal of Functional Biomaterials 16, no. 12: 447. https://doi.org/10.3390/jfb16120447

APA Style

Meyer, M., Smaida, R., Favreau, H., Yus, C., Gegout, H., Arruebo, M., Bahlouli, N., Ladam, G., Conzatti, G., Lemmens, S., Hua, G., Fioretti, F., & Benkirane-Jessel, N. (2025). Biomimetic Glycosaminoglycan-Enriched Electrospun Polymeric Scaffolds for Enhanced Early Tissue Regeneration. Journal of Functional Biomaterials, 16(12), 447. https://doi.org/10.3390/jfb16120447

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop