Silk Protein-Based Functional and Innovative Materials for Biomedical Applications

A special issue of Journal of Functional Biomaterials (ISSN 2079-4983). This special issue belongs to the section "Biomaterials and Devices for Healthcare Applications".

Deadline for manuscript submissions: 31 March 2026 | Viewed by 686

Special Issue Editors


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Guest Editor
Institute of Materials for Electronics and Magnetism (IMEM-CNR), Parco Area delle Scienze 37/A, 43124 Parma, Italy
Interests: biomaterials; nanomaterials; bioengineering; drug delivery; molecular biology

E-Mail Website
Guest Editor
Institute of Materials for Electronics and Magnetism (IMEM-CNR), Parco Area delle Scienze 37/A, 43124 Parma, Italy
Interests: organic electronics; biomaterials; biochemistry; biosensing; unconventional computing

E-Mail Website
Guest Editor
Institute of Materials for Electronics and Magnetism (IMEM-CNR), Parco Area delle Scienze 37/A, 43124 Parma, Italy
Interests: bioelectronics; wearable electronics; additive manufacturing; biomaterials; electrochemistry

Special Issue Information

Dear Colleagues,

Silk is a natural biopolymer. In modern times, the optimization of silkworm (Bombyx mori) breeding has allowed for its large-scale production, thanks to technological advancements and genetic modifications, which have improved the material’s final quality. Raw silkworm silk is composed of 70-80% fibroin and 20-30% sericin.

Silk fibroin (SF) fibers can be processed to obtain aqueous solutions of regenerable fibroin, which can be used to produce materials with varying mechanical and morphological properties, such as films, hydrogels, porous structures, and nanoparticles. Silk fibroin-based materials are increasingly studied for applications in biomedicine, biotechnology, optics, and electronics. The exceptional biocompatibility of SF, along with its excellent mechanical properties, is one of its most extensively researched and characteristic features. SF exhibits low allergenicity and immunogenicity, and its use as a biomaterial has recently been approved by the FDA.

Silk sericin (SS) has recently transitioned from a mere byproduct of silk manufacturing to a material of significant interest, driven by the principles of circular economy and improved waste management. SS has also unlocked its potential for diverse applications, including tissue engineering, drug delivery, cosmetics, and sensing. Similarly to its well-known counterpart, sericin exhibits biocompatibility, biodegradability, and anti-inflammatory/antioxidative properties. Moreover, FDA’s approval has recently been granted for SS, paving the way for expanded applications of sericin in material science and biotechnology.

This Special Issue aims to fulfill recent and groundbreaking advances in silk protein-based biomaterials. We invite original manuscripts focusing on SF- and/or SS-based materials’/compounds’ functionality, characterization, applications and design. Furthermore, we will welcome research articles and review papers related to silk proteins. To all the potential contributors of this Special Issue, JFB looks forward to receiving your submissions.

Dr. Giuseppe De Giorgio
Dr. Giuseppe Tarabella
Dr. Davide Vurro
Guest Editors

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Keywords

  • biomaterials
  • bioengineering
  • bioelectronics
  • drug delivery platforms
  • three-dimensional printing
  • innovative manufacturing
  • silk proteins

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Published Papers (1 paper)

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Research

17 pages, 2753 KB  
Article
Three-Dimensional Human Neurovascular Unit Modeling Reveals Cell-Specific Mechanisms of Traumatic Brain Injury
by Liam H. Power, Evan C. Marcet, Zihong Chen, Jinpeng Chen, Artem Arkhangelskiy, Michael J. Whalen, Ying Chen and David L. Kaplan
J. Funct. Biomater. 2025, 16(12), 454; https://doi.org/10.3390/jfb16120454 - 7 Dec 2025
Viewed by 395
Abstract
Severe traumatic brain injury includes neurovascular unit (NVU) damage that is linked to the later development of neurodegenerative diseases. Cell-type-specific contributions and crosstalk between cells of the neurovascular unit following brain injury remain poorly defined in human cells. Here, we developed a three-dimensional [...] Read more.
Severe traumatic brain injury includes neurovascular unit (NVU) damage that is linked to the later development of neurodegenerative diseases. Cell-type-specific contributions and crosstalk between cells of the neurovascular unit following brain injury remain poorly defined in human cells. Here, we developed a three-dimensional (3D) human NVU model using silk–collagen scaffolds to examine cellular responses to controlled cortical impact (CCI). Using this platform, we show that CCI induced acute cell death in astrocytes, microglia, and endothelial cells but spared pericytes, which occurred independently of classical apoptotic or necroptotic pathways. Astrocytes and microglia were the primary sources of early bioactive IL-1β release, while endothelial junctional integrity was differentially regulated by support cells: astrocytes destabilized VE-cadherin, pericytes preserved barrier proteins, and microglia contributed to Claudin-5 loss in multicellular settings. Conditioned media experiments demonstrated that soluble factors from injured support cells alone were sufficient to disrupt endothelial junctional proteins (ZO-1 and Occludin) and induce inflammatory adhesion molecules (ICAM-1 and VCAM-1). Together, these findings define cell-type-specific injury responses and reveal how NVU interactions regulate vascular dysfunction after trauma, providing a human-based framework for understanding blood–brain barrier (BBB) disruption following traumatic brain injury (TBI). Full article
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