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Nanomaterials for Drug Delivery Systems
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Nanomaterials for Drug Delivery Systems

A special issue of Journal of Functional Biomaterials (ISSN 2079-4983). This special issue belongs to the section "Biomaterials for Drug Delivery".

Deadline for manuscript submissions: 31 January 2026 | Viewed by 452

Special Issue Editor

Dr. Ivalina Trendafilova

E-Mail Website
Guest Editor
Institute of Organic Chemistry with Centre of Phytochemistry, Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria
Interests: materials science; porous silica; surface modification; surface interactions; drug delivery systems; drug release; nanotheranostics
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

We are pleased to invite you to contribute а research article, short communication, or review paper to this Special Issue entitled "Nanomaterials for Drug Delivery System" of Journal of Functional Biomaterials (IF 5.2, ranks Q2). This Special Issue aims to present recent advances and emerging trends in the application of nanomaterials for the preparation of highly effective drug delivery systems.

The development of advanced drug delivery systems represents a rapidly evolving field at the intersection of nanotechnology, materials science, and biomedicine. Nanomaterials offer unique physicochemical properties—such as a high surface area, tunable surface chemistry, and the controllable size and shape of particles—that make them highly suitable for targeted delivery, controlled release, and stimuli-responsive delivery applications.

This Special Issue aims to highlight recent advances in the design, synthesis, functionalization, and biomedical application of nanomaterials for drug delivery. We therefore welcome contributions that focus on innovative strategies to improve therapeutic efficacy, minimize side effects, and enable site-specific drug release. In addition, we welcome the submission of original research articles and comprehensive reviews that address the experimental, computational, or theoretical aspects of nanomaterials in drug delivery systems.

Dr. Ivalina Trendafilova
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Functional Biomaterials is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • drug delivery systems design
  • nanomaterials for drug delivery
  • biocompatible nanomaterials
  • functional biomaterials
  • controlled release
  • target drug delivery
  • nanotheranostics

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Published Papers (1 paper)

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Research

18 pages, 3761 KB  
Article
Hexapeptide-Liposome Nanosystem for the Delivery of Endosomal pH Modulator to Treat Acute Lung Injury
by Yuting Ji, Qian Wang, Rujing Lin, Mimi Pang, Liya Sun, Jiameng Gong, Huiqiang Ma, Shan-Yu Fung and Hong Yang
J. Funct. Biomater. 2025, 16(12), 450; https://doi.org/10.3390/jfb16120450 - 1 Dec 2025
Viewed by 331
Abstract
The overactivation of endosomal Toll-like receptor (TLR) in macrophages plays an important role in the pathogenesis of acute lung injury (ALI). There is currently still a lack of nano-formulated and macrophage-targeted endosomal TLR inhibitors that have been approved for clinical uses. We previously [...] Read more.
The overactivation of endosomal Toll-like receptor (TLR) in macrophages plays an important role in the pathogenesis of acute lung injury (ALI). There is currently still a lack of nano-formulated and macrophage-targeted endosomal TLR inhibitors that have been approved for clinical uses. We previously discovered that the elevation of endosomal pH using nanodevices provides a promising strategy to specifically inhibit endosomal TLRs in macrophages. The weakly basic drug hydroxychloroquine (HCQ) has been reported for its capability to accumulate in endolysosomes and modulate the acidity in these compartments. To enhance its macrophage-targeting ability and the therapeutic efficacy in vivo, herein we formulated HCQ into a nanoform using liposomes, named HCQ-L. We found that HCQ-L was less cytotoxic and more effective in inhibiting endosomal TLRs (including TLR3, TLR4, TLR 7/8) than the molecular HCQ. Subsequently, a hexapeptide, Pep12, was inserted onto the surface of HCQ-L to form HCQ-L-P12. Interestingly, Pep12 modification significantly improved the stability of liposomes in aqueous solution for at least 2 years; while having enhanced inhibitory effects on TLR7/8 signaling, HCQ-L-P12 displayed similar effects on inhibiting the TLR4 pathway and down-stream pro-inflammatory cytokine production when compared with HCQ-L. Furthermore, both HCQ nanoformulations potently elevated the endosomal pH. In vivo evaluation showed that HCQ-L-P12 and HCQ-L (but not molecular HCQ) were able to alleviate lung inflammation and injuries by decreasing inflammatory cell infiltration upon intratracheal instillation in a lipopolysaccharide (LPS)-induced acute lung injury (ALI) mouse model. This research provides a new strategy to fabricate lipid-based nanocarriers for targeted delivery of endosomal pH modulators to treat ALI and other acute and chronic inflammatory disorders. Full article
(This article belongs to the Special Issue Nanomaterials for Drug Delivery Systems)
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