2026 April-2 - 369 articles
Background/Objectives: Ogilvie’s syndrome, or acute colonic pseudo-obstruction (ACPO), is defined by acute colonic dilatation without mechanical obstruction and carries a risk of ischemia and perforation if not promptly managed. Treatment strat...
Objective: To evaluate whether documented bacterial infection or neutropenic fever is associated with delayed hematopoietic recovery in patients with acute leukemia undergoing induction or consolidation chemotherapy. Methods: We conducted a retrospec...
Background: Frail patients undergoing hip and knee revision surgery represent a major anesthetic challenge because of advanced age and multiple comorbidities. Continuous spinal anesthesia (CSA) with titrated low-dose levobupivacaine may offer a poten...
Background/Objectives: Overcrowding in emergency departments (EDs) remains a critical challenge in modern healthcare systems, driven in part by patient uncertainty regarding symptom urgency and a lack of accessible medical guidance. Recent advances i...
Transcatheter structural heart interventions, including aortic, mitral and tricuspid valve replacement or repair, and patent foramen ovale, atrial septal defect, and left atrial appendage closure, have dramatically expanded over the past two decades,...
Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disease in which B-cell dysregulation plays a central pathogenic role beyond autoantibody production. Advances in B-cell biology have led to the development of targeted therapies, inclu...
Background/Objectives: Beyond glycemic control, oral antidiabetic drugs (OADs) may exert class-specific effects on muscle mass and hematologic parameters. However, real-world evidence comparing these effects across OAD classes remains limited. This s...
Aim: Percutaneous liver ablation is a challenging procedure and operator-dependent. During the time when transarterial liver oncological therapies are favored over percutaneous liver ablation, we discuss the challenges of liver ablation with bowel in...
Background: Patients with advanced chronic kidney disease (CKD) experience disproportionately high ischemic and bleeding risks following acute coronary syndrome (ACS), yet remain markedly underrepresented in randomized trials of antiplatelet therapy....
Background/Objectives: To evaluate the short-term effects of structured physical activity (PA), alone or combined with dietary counselling, in early-stage chronic kidney disease (CKD) patients managed in primary healthcare (PHC). Methods: This non-ra...
Objective: We aimed to determine the ability of prenatal ultrasound to detect velamentous cord insertion (VCI) in twin pregnancies and identify factors influencing diagnostic sensitivity. Methods: This single-center retrospective study included twins...
Objective: To evaluate the potential utility of the ratio of the maximal diameter of the bulging foramen ovale flap to the left atrial diameter (FOFD/LAD) for distinguishing false-positive prenatal suspicion of fetal coarctation of the aorta (CoA), a...
Background: Accurate differentiation of kidney diseases such as cysts, tumors, stones, and normal tissue from computed tomography (CT) images remains challenging due to overlapping visual characteristics and variability in data distributions. While d...
Objectives: Hidradenitis suppurativa (HS) is a chronic, inflammatory skin disease that significantly impairs patients’ quality of life, especially in its moderate to severe forms. Traditional treatments, including antibiotics, hormonal therapie...
Background: Treatment of failed osteosynthesis of fractures of the proximal humerus with one-stage or two-stage surgery is difficult and clinical results are poor. The aim of this work is to evaluate the microbiological positivity of devices removed...
Background/Objectives: Oral squamous cell carcinoma (OSCC) accounts for over 90% of oral malignancies and remains associated with substantial global morbidity and mortality. Although tobacco and alcohol are established risk factors, they do not fully...
Background/Objectives: Coronary perforations are infrequent but potentially fatal complications during percutaneous coronary intervention (PCI). Interventional management aims to stop extravasation and restore distal flow to prevent tamponade and car...
Background: Treatment options for vulvar lichen sclerosus (VLS) remain limited; therefore, therapies that improve quality of life and reduce neoplastic risk are needed. Photodynamic therapy (PDT) is a potential option. This study aimed to evaluate qu...
Background: Chronic low-grade inflammation contributes to early glucose dysregulation, but comparative evidence on complete blood count-derived inflammatory indices in prediabetes remains limited. This study aimed to compare the associations of five...
Background/Objectives: This study aimed to investigate the impact of allergic diseases (AD) or obstructive sleep apnea (OSA) risk, as a host factor, on the development of severe Mycoplasma pneumoniae Pneumonia (SMPP) in children by analyzing the clin...
Background: The Middle East and North Africa (MENA) region faces a high cardiovascular disease (CVD) burden alongside endemic serum 25(OH)D (vitamin D) deficiency. This systematic review examines the relationship between vitamin D deficiency and CVD...
Background/Objectives: Squamous cell metaplastic breast carcinoma (SCMBC) is a rare and aggressive breast cancer subtype with limited imaging and prognostic data. This study aimed to characterize the multimodal imaging features, clinicopathological p...
Background/Objectives: Brain death determination in children is clinically challenging. When standard clinical examination cannot be completed or reliably interpreted, ancillary testing is required—yet many established methods depend on infrast...
Introduction: Pancreatic cancer is one of the most lethal malignancies worldwide, and its incidence continues to rise. Periodontitis, a highly prevalent chronic inflammatory disease, has been linked to several systemic conditions, including a potenti...
Background/Objectives: Type 2 diabetes mellitus (DM) commonly coexists with heart failure (HF) and is associated with increased cardiovascular (CV) morbidity and mortality. Although dipeptidyl peptidase-4 (DPP-4) inhibitors are widely used for glycem...
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Background: The elderly are vulnerable to chronic diseases and altered lipid metabolism, leading to poor outcomes, including mortality. We investigated the association between Korean Medicine (KM) utilization, blood lipid levels, and health outcomes...
Background/Objectives: High-risk prostate cancer patients undergoing radical prostatectomy remain at significant risk of biochemical recurrence and metastasis. Immediate adjuvant external beam radiotherapy (EBRT) has been proposed to improve outcomes...
Background/Objectives: The objective of this investigation was to assess the prevalence of sarcopenia and identify its related risk factors in patients with rheumatoid arthritis (RA) using data from the nationally representative 2008–2011 Korea...
Background/Objectives: This qualitative study investigated the perspectives and lived experiences of individuals with obesity, with a specific focus on psychological needs, beliefs, attitudes, and experiences related to psychological support. The stu...
Cytisine is a plant-derived quinolizidine alkaloid found, among other sources, in the seeds of the common laburnum (Laburnum anagyroides). It has properties that enable it to act as a partial agonist of brain nicotinic α4β2 receptors, whic...
Background: Corneal sensitivity is a key indicator of ocular surface health. This prospective, cross-sectional study evaluated agreement between corneal sensitivity thresholds obtained from equivalent stimulus settings on a contemporary, enhanced dua...
Background: Despite advances in cleft rhinoplasty, the nasal sill remains an underappreciated subunit, yet it plays a crucial role in nostril symmetry and aesthetic balance. Hypoplasia or absence of the nasal sill on the cleft side often persists aft...
Liver transplantation remains the definitive treatment for end-stage liver disease and acute liver failure, yet a critical and persistent shortage of donor organs results in thousands of preventable deaths annually worldwide. Xenotransplantation has...
Background: Congenital heart disease (CHD) represents a major cause of perinatal morbidity and mortality, and fetal echocardiography is essential for its early diagnosis and management. Maternal smoking has been suggested as a potential teratogenic f...
Background/Objectives: To evaluate changes in corneal topography and densitometry (CD) 3 months after accelerated corneal collagen crosslinking (CXL) for keratoconus and to investigate influencing factors. Methods: Twenty-one (41 eyes) patients with...
Background: Achondroplasia, the most common genetic dwarfism caused by the FGFR3 mutation (autosomal dominant, 80% de novo), results in a disproportionately short stature. Thoracolumbar kyphosis (TLK), combined with characteristic spinal canal stenos...
Background: Pulmonary embolism (PE) is a major cause of morbidity and in-hospital mortality and requires rapid clinical assessment for diagnosis, risk stratification, and management. Several validated clinical prediction tools, including the Pulmonar...
Over the past decades, neurosurgery has undergone a profound transformation driven by technological innovation and a paradigm shift toward patient-centered outcomes. Historically evaluated through mortality rates and extent of resection, modern neuro...
Background: Test descriptions from major diagnostic manufacturers do not include ferritin reference intervals (RIs) for individuals aged 60 and older. The absence of older adults-specific RIs contrasts with the widespread use of serum ferritin testin...
Background/Objectives: Sepsis is a leading cause of hospital mortality and represents a time-sensitive medical emergency. Current diagnostic strategies rely on clinical assessment, severity scores, biomarkers, and blood cultures. However, blood cultu...
Background: Inhaled therapy is the mainstay of asthma management, yet many patients are prescribed pressurized metered-dose inhalers (pMDIs) with valved holding chambers (VHCs) based on a presumed low inspiratory capacity, often without objective mea...
Background: Past workplace exposure to asbestos in combination with tobacco smoking has increased the risk of lung cancer for some residents in an area within the Friuli Venezia Giulia region, Northeast Italy. In light of studies showing that lung ca...
Background/Objectives: The American Heart Association Life’s Essential 8 (LE8) is a tool proposed to categorize overall cardiovascular health (CVH), ranging from 0 to 100 and classifies CVH as low (<50), moderate (50–79) or high (≥8...
Background: Thoracentesis is pivotal in managing pleural effusion (PE), particularly in invasive mechanical ventilation (IMV), with documented improvements in respiratory mechanics, oxygenation, and hemodynamic parameters. However, its efficacy may v...
Background/Objectives: Psychological pain—also termed psychache or mental pain—has been suggested to constitute a relevant factor in the emergence of suicidal behaviour. Despite conceptual advances, empirical research on interventions spe...
Objectives: The transition from in-person to online formats for clinical case discussions has transformed the way medical professionals collaborate and share knowledge. The current pilot study investigates the potential impact of this shift by compar...
Background/Objectives: Twin pregnancies carry substantially elevated perinatal risks, yet tools for first-trimester risk stratification remain limited. This retrospective cohort study evaluated the predictive value of crown–rump length (CRL) an...
Background/Objectives: Digital media play an important role in the lives of contemporary adolescents. While associated with many benefits, they also pose risks to physical health related to prolonged screen time and non-ergonomic body posture. This s...
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