Sepsis and Septic Shock: Diagnosis, Treatment, and Prognosis
A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Intensive Care".
Deadline for manuscript submissions: 20 August 2026 | Viewed by 4
Special Issue Editors
Interests: sepsis; septic shock; diagnosis and screening tools; risk stratification; machine learning; advanced therapies
2. Department of Translational Medicine and Surgery, Università Cattolica del Sacro Cuore, Rome, Italy
3. IBD UNIT-CEMAD (Centro Malattie Apparato Digerente), Medicina Interna e Gastroenterologia, Fondazione Policlinico A. Gemelli IRCCS, Rome, Italy
Interests: inflammatory bowel disease; ulcerative colitis; clinical surgery; gastrointestinal diseases
Special Issue Information
Dear Colleagues,
The Special Issue, “Sepsis and Septic Shock: Diagnosis, Treatment, and Prognosis”, aims to examine current knowledge, ongoing controversies, and future directions in the diagnosis, management, and prognostic assessment of sepsis and septic shock.
Sepsis—a life-threatening condition characterized by organ dysfunction resulting from a dysregulated host response to infection—remains a major global health challenge due to its complex pathophysiology, evolving definitions, and wide variability in clinical practice.
Optimal management strategies, including resuscitation targets, fluid administration approaches, vasopressor use, and the development of emerging targeted therapies, continue to be debated. This issue will review updated diagnostic frameworks such as Sepsis-3, the role of the SOFA score, and the limitations of current screening tools, including SIRS and qSOFA.
Particular attention will be given to integrating new evidence, identifying gaps in current practice, and evaluating innovative methods—such as machine learning and AI-based tools—to enhance early diagnosis, risk stratification, and overall patient outcomes.
The ultimate goal is to synthesize the latest literature and help guide future strategies toward more accurate, timely, and effective management of sepsis across diverse clinical settings.
Dr. Luigi Carbone
Dr. Daniela Pugliese
Guest Editors
Manuscript Submission Information
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Keywords
- sepsis
- septic shock
- diagnosis and screening tools
- risk stratification
- machine learning
- advanced therapies
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