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Journal of Clinical Medicine, Volume 14, Issue 5

March-1 2025 - 384 articles

Cover Story: Patient-Reported Outcome Measures (PROMs) have been used extensively to monitor pain, mobility, and quality of life following Total Hip Arthroplasty (THA). Despite the popularity of the modified Harris Hip Score (mHHS) to monitor PROMs following THA over the last 5 decades, International Joint Registries have recently favoured the Hip disability and Osteoarthritis Outcome Score (HOOS). The ability to convert mHHS collected in historical and ongoing studies would be beneficial for benchmarking more recent HOOS reports. We have used a crosswalk methodology to create the first multi-directional crosswalk between the mHHS and HOOS and the mHHS and HOOS-12. Our crosswalks can be used to compare the outcome of THA in prospective studies while using older PROM collections as a control or quality-assurance benchmark. View this paper
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Articles (384)

  • Article
  • Open Access
1 Citations
2,134 Views
13 Pages
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Morbidity and Mortality Outcomes After Cytoreductive Surgery with Hyperthermic Intraperitoneal Chemotherapy for Treatment of Ovarian Cancer

  • Migang Kim,
  • Yong Jae Lee,
  • Ki Eun Seon,
  • Sunghoon Kim,
  • Chan Lee,
  • Hyun Park,
  • Min Chul Choi and
  • Jung-Yun Lee
J. Clin. Med.2025, 14(5), 1782;https://doi.org/10.3390/jcm14051782

6 March 2025

Background/Objectives: Hyperthermic intraperitoneal chemotherapy (HIPEC) with cytoreductive surgery (CRS) has been reported to improve survival in patients with peritoneal carcinomatosis. This study aimed to investigate the morbidity and mortality ra...

Full Article
  • Article
  • Open Access
1 Citations
1,977 Views
14 Pages
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The Prognostic Implication of Late Gadolinium Enhancement Quantification and Syncope in Hypertrophic Cardiomyopathy

  • Christopher Mann,
  • Theresa M. Dachs,
  • Diana Gharib,
  • Katalin Widmann,
  • Rodi Tosun,
  • Marc Srdits,
  • Christina Kronberger,
  • Dietrich Beitzke,
  • Christian Loewe and
  • Andreas A. Kammerlander
  • + 5 authors
J. Clin. Med.2025, 14(5), 1781;https://doi.org/10.3390/jcm14051781

6 March 2025

Background: Risk stratification for sudden cardiac death in hypertrophic cardiomyopathy (HCM) remains challenging. Late gadolinium enhancement (LGE) on cardiac MRI signifies myocardial fibrosis and is linked to adverse outcomes in HCM. However, the t...

Full Article
  • Review
  • Open Access
7 Citations
5,318 Views
20 Pages
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Frozen Shoulder as a Metabolic and Immune Disorder: Potential Roles of Leptin Resistance, JAK-STAT Dysregulation, and Fibrosis

  • Santiago Navarro-Ledesma
J. Clin. Med.2025, 14(5), 1780;https://doi.org/10.3390/jcm14051780

6 March 2025

Frozen shoulder (FS) is a complex and multifactorial condition characterized by persistent inflammation, fibrosis, and metabolic dysregulation. Despite extensive research, the underlying drivers of FS remain poorly understood. Recent findings indicat...

Full Article
  • Systematic Review
  • Open Access
1,371 Views
17 Pages
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Posterior Hypopharyngeal/Upper Esophageal Wall Reconstruction Using a Double-Island Free Fasciocutaneous Anterolateral Thigh Flap: A Case Report and Scoping Review of the Literature

  • Léna G. Dietrich,
  • Vera A. Paulus,
  • Mihai A. Constantinescu,
  • Moritz C. Deml,
  • Roland Giger and
  • Ioana Lese
J. Clin. Med.2025, 14(5), 1779;https://doi.org/10.3390/jcm14051779

6 March 2025

Background/Objectives: Isolated defects of the posterior hypopharyngeal/upper esophageal wall are rare, typically arising after cancer resection or complications following cervical spine osteosynthesis. Various local and free flaps are available for...

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  • Article
  • Open Access
1,475 Views
10 Pages
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Outcomes and Predictive Factors of I-125 Plaque Therapy for Refractory Retinoblastoma

  • Yacoub A. Yousef,
  • Farah Halawa,
  • Mona Mohammad,
  • Lama Al-Fahoum,
  • Rama Soudi,
  • Mustafa Mehyar,
  • Reem AlJabari,
  • Hadeel Halalsheh,
  • Ibrahim AlNawaiseh and
  • Imad Jaradat
J. Clin. Med.2025, 14(5), 1778;https://doi.org/10.3390/jcm14051778

6 March 2025

Objective: This study aimed to evaluate the outcomes and predictive factors of I-125 radioactive plaque therapy for recurrent and refractory retinoblastoma (Rb) cases that failed primary systemic chemotherapy and focal therapies. Methods: A retrospec...

Full Article
  • Article
  • Open Access
1 Citations
4,188 Views
13 Pages
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Effects of Walking and Barre Exercise on CES-D, Stress Hormones, hs-CRP, and Immunoglobulins in Elderly Women

  • Min-Kyo Kim,
  • Su-Han Koh and
  • Tae-Kyu Kim
J. Clin. Med.2025, 14(5), 1777;https://doi.org/10.3390/jcm14051777

6 March 2025

Objectives: This study explored the impact of a 12-week walking and barre exercise program on depression levels (CES-D), stress hormones (dopamine, epinephrine, norepinephrine, cortisol, serotonin), high-sensitivity C-reactive protein (hs-CRP), and i...

Full Article
  • Systematic Review
  • Open Access
3 Citations
1,972 Views
13 Pages
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Efficacy and Safety of Combination Therapy with PARP Inhibitors and Anti-Angiogenic Agents in Ovarian Cancer: A Systematic Review and Meta-Analysis

  • István Baradács,
  • Brigitta Teutsch,
  • Ádám Vincze,
  • Péter Hegyi,
  • Bence Szabó,
  • Péter Nyirády,
  • Nándor Ács,
  • Zsolt Melczer,
  • Ferenc Bánhidy and
  • Balázs Lintner
J. Clin. Med.2025, 14(5), 1776;https://doi.org/10.3390/jcm14051776

6 March 2025

Introduction: Ovarian cancer is a significant contributor to gynecological cancer-related mortality, necessitating innovative treatment strategies. This systematic review and meta-analysis aimed to assess the efficacy and safety of combining PARP inh...

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  • Article
  • Open Access
1 Citations
1,113 Views
12 Pages
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Investigation of MicroRNA-17 Expression, Tumor Necrosis Factor-α, and Interleukin-6 Levels in Lumbar Degenerative Disc Disease: Case–Control Study

  • Luay Şerifoğlu,
  • Müge Kopuz Álvarez Noval,
  • Selvi Duman Bakırezer,
  • Seda Güleç Yılmaz,
  • Eyüp Varol,
  • Muhittin Emre Altunrende,
  • Ali Haluk Düzkalır and
  • Selçuk Özdoğan
J. Clin. Med.2025, 14(5), 1772;https://doi.org/10.3390/jcm14051772

6 March 2025

Background/Objectives: The aim of the study is to investigate the role of microRNA-17 (miRNA-17), tumor necrosis factor-alpha (TNF-α), and interleukin-6 (IL-6) in the pathogenesis of lumbar degenerative disc disease (LDDD). The goal is to explo...

Full Article
  • Systematic Review
  • Open Access
1 Citations
2,140 Views
16 Pages
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Comminuted Mason III/IV Radial Head Fractures: What Is the Best Treatment Between Prosthesis and Radial Head Resection? A Systematic Review and Meta-Analysis

  • Luca Bianco Prevot,
  • Livio Pietro Tronconi,
  • Vittorio Bolcato,
  • Riccardo Accetta,
  • Stefania Fozzato and
  • Giuseppe Basile
J. Clin. Med.2025, 14(5), 1773;https://doi.org/10.3390/jcm14051773

6 March 2025

Background/Objectives: Various surgical methods have been proposed for the treatment of comminuted Mason III/IV radial head fractures. In particular, the advantages and disadvantages between prosthesis implantation (RHA) or radial head resection (RHR...

Full Article
  • Feature Paper
  • Article
  • Open Access
1,407 Views
14 Pages
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Effectiveness of Etanercept Biosimilar Initiating for Etanercept-Naive Patients, Using Ultrasound, Clinical, and Biomarker Assessments in Outcomes of Real-World Therapy (ENPORT-NGSK Study): An Interventional, Multicenter, Open-Label, Single-Arm Clinical Trial

  • Remi Sumiyoshi,
  • Shin-ya Kawashiri,
  • Toshimasa Shimizu,
  • Tomohiro Koga,
  • Rieko Kiya,
  • Shigeki Tashiro,
  • Yurika Kawazoe,
  • Shuntaro Sato,
  • Yukitaka Ueki and
  • Takahisa Suzuki
  • + 5 authors
J. Clin. Med.2025, 14(5), 1775;https://doi.org/10.3390/jcm14051775

6 March 2025

Background/Objectives: This study aimed to investigate the effectiveness of etanercept biosimilar 1 under real-world clinical conditions in patients with rheumatoid arthritis (RA), using not only clinical evaluation but also musculoskeletal ultrasoun...

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J. Clin. Med. - ISSN 2077-0383
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