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Vaccines, Volume 12, Issue 2

February 2024 - 109 articles

Cover Story: Avian influenza viruses have demonstrated their pandemic potential by infecting humans. This study investigated the utility of influenza virus nucleoprotein (NP) and an autophagy-inducing peptide called C5 (AIP-C5) in developing a universal influenza vaccine for pandemic preparedness. Our findings reveal that the adenovirus vector carrying the influenza NP and AIP-C5 [HAd-C5-NP(H7N9)] elicits an enhanced cell-mediated immune response and confers broad protection against influenza A viruses. Notably, this vaccine vector affords protection against both seasonal and avian influenza A viruses in mice. View this paper
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Articles (109)

  • Article
  • Open Access
2,409 Views
13 Pages

19 February 2024

Background: An inactivated poliomyelitis vaccine made from Sabin strains (sIPVs) has widely been used in China since 2015. However, the quantitative data on the instant and persistent inhibition effects of maternal poliovirus antibodies on the immune...

  • Review
  • Open Access
14 Citations
8,277 Views
17 Pages

19 February 2024

Recommending co-administration of influenza and COVID-19 vaccines has emerged as a strategy to enhance vaccination coverage. This study describes the policy on co-administration and uptake of influenza and COVID-19 vaccination in Europe, the United K...

  • Article
  • Open Access
5 Citations
3,731 Views
12 Pages

The Chimeric Chaoyang-Zika Vaccine Candidate Is Safe and Protective in Mice

  • Hao-Long Dong,
  • Zhi-Li Chen,
  • Mei-Juan He,
  • Jia-Zhen Cui,
  • Hao Cheng,
  • Qing-Yang Wang,
  • Xiang-Hua Xiong,
  • Gang Liu and
  • Hui-Peng Chen

19 February 2024

Zika virus (ZIKV) is an emerging flavivirus that causes congenital syndromes including microcephaly and fetal demise in pregnant women. No commercial vaccines against ZIKV are currently available. We previously generated a chimeric ZIKV (ChinZIKV) ba...

  • Article
  • Open Access
1 Citations
3,878 Views
17 Pages

Impaired IgM Memory B Cell Function Is Common in Coeliac Disease but Conjugate Pneumococcal Vaccination Induces Robust Protective Immunity

  • Olivia G. Moscatelli,
  • Amy K. Russell,
  • Lee M. Henneken,
  • Melinda Y. Hardy,
  • Nadia Mazarakis,
  • Rachel Higgins,
  • Jesse Ekin,
  • Harry McLeod,
  • Paul Simkin and
  • Paul V. Licciardi
  • + 2 authors

19 February 2024

Coeliac disease (CD) is associated with hyposplenism, an acquired impairment of spleen function associated with reduced IgM memory B cells and increased susceptibility to serious pneumococcal infection. Little is known about the immune implications o...

  • Review
  • Open Access
8 Citations
5,846 Views
17 Pages

18 February 2024

Chronic obstructive pulmonary disease (COPD) is a frequent, often progressive, chronic disease of the lungs. Patients with COPD often have impaired immunity; therefore, they are prone to chest infections, such as pneumonia or bronchitis. Acute exacer...

  • Review
  • Open Access
21 Citations
5,445 Views
15 Pages

18 February 2024

Porcine epidemic diarrhea (PED) is a swine-wasting disease caused by coronavirus infection. It causes great economic damage to the swine industry worldwide. Despite the continued use of vaccines, PED outbreaks continue, highlighting the need to revie...

  • Article
  • Open Access
4,173 Views
14 Pages

18 February 2024

The COVID-19 pandemic prompted rapid vaccine development and deployment worldwide. Despite widespread vaccination efforts, understanding the effectiveness of vaccines in hospitalized patients remains a critical concern. This retrospective cohort stud...

  • Article
  • Open Access
3 Citations
3,381 Views
13 Pages

Long-Term Clinical Safety of the Ad26.ZEBOV and MVA-BN-Filo Ebola Vaccines: A Prospective, Multi-Country, Observational Study

  • Adeep Puri,
  • Andrew J. Pollard,
  • Catherine Schmidt-Mutter,
  • Fabrice Lainé,
  • George PrayGod,
  • Hannah Kibuuka,
  • Houreratou Barry,
  • Jean-François Nicolas,
  • Jean-Daniel Lelièvre and
  • Sodiomon Bienvenu Sirima
  • + 8 authors

17 February 2024

In this prospective, observational study (ClinicalTrials.gov Identifier: NCT02661464), long-term safety information was collected from participants previously exposed to the Ebola vaccines Ad26.ZEBOV and/or MVA-BN-Filo while enrolled in phase 1, 2, o...

  • Article
  • Open Access
2 Citations
2,855 Views
19 Pages

Serum SARM1 Levels and Diabetic Peripheral Neuropathy in Type 2 Diabetes: Correlation with Clinical Neuropathy Scales and Nerve Conduction Studies and Impact of COVID-19 vaccination

  • Moafaq S. Alrawaili,
  • Ahmad R. Abuzinadah,
  • Aysha A. AlShareef,
  • Emad A. Hindi,
  • Ahmed K. Bamaga,
  • Weam Alshora and
  • Hashim Sindi

17 February 2024

Patients with peripheral neuropathy with type 2 diabetes mellitus (T2DM) are more likely to have functional impairments. Recently, the gene for serum sterile alpha and toll/interleukin receptor motif-containing protein 1 (SARM1), which may contribute...

  • Article
  • Open Access
1 Citations
7,103 Views
20 Pages

IgG Subclass Switch in Volunteers Repeatedly Immunized with the Full-Length Plasmodium falciparum Merozoite Surface Protein 1 (MSP1)

  • Veronika Rathay,
  • Kristin Fürle,
  • Viktoria Kiehl,
  • Anne Ulmer,
  • Michael Lanzer and
  • Richard Thomson-Luque

17 February 2024

Vaccines are highly effective tools against infectious diseases and are also considered necessary in the fight against malaria. Vaccine-induced immunity is frequently mediated by antibodies. We have recently conducted a first-in-human clinical trial...

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Vaccines - ISSN 2076-393X