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Volume 12
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10.3390/vaccines12020170
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Article

Intussusception and Other Adverse Event Surveillance after Pilot Introduction of Rotavirus Vaccine in Nam Dinh and Thua Thien Hue Provinces—Vietnam, 2017–2021

by
Ly Khanh Thi Le
1,
Thao Phuong Thi Pham
2,
Le Thi Phuong Mai
1,
Quyet Tu Nguyen
1,
Mai Phuong Ngoc Tran
1,
Thien Huu Ho
3,
Hung Hoang Pham
3,
Sanh Van Le
4,
Ha Ngoc Hoang
5,
Anh Tuan Lai
6,
Nguyen Thuy Huong
2,
Hien Dang Nguyen
2,
Dang Duc Anh
1,
Makiko Iijima
7,
Umesh D. Parashar
8,
Nguyen Van Trang
1,* and
Jacqueline E. Tate
8,*
1
National Institute of Hygiene and Epidemiology, Hanoi 100000, Vietnam
2
Center for Research and Production of Vaccines and Biologicals, Hanoi 100000, Vietnam
3
Central Hue Hospital, Thua Thien Hue 530000, Vietnam
4
Hue Center for Disease Control, Thua Thien Hue 530000, Vietnam
5
Nam Dinh General Hospital, Nam Dinh 420000, Vietnam
6
Nam Dinh Center for Disease Control, Nam Dinh 420000, Vietnam
7
World Health Organization, Vietnam Office, Hanoi 100000, Vietnam
8
United States Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
*
Authors to whom correspondence should be addressed.
Vaccines 2024, 12(2), 170; https://doi.org/10.3390/vaccines12020170
Submission received: 20 December 2023 / Revised: 29 January 2024 / Accepted: 2 February 2024 / Published: 7 February 2024
(This article belongs to the Special Issue Research in Vaccine Epidemiology: Immunogenicity, Effectiveness, and Safety)
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Abstract

Rotavin-M1 (POLYVAC) was licensed in Vietnam in 2012. The association of Rotavin-M1 with intussusception, a rare adverse event associated with rotavirus vaccines, and with adverse events following immunization (AEFI) have not been evaluated and monitored under conditions of routine use. From February 2017 to May 2021, we conducted a pilot introduction of Rotavin-M1 into the routine vaccination program in two provinces. Surveillance for intussusception was conducted at six sentinel hospitals. AEFI reports at 30 min and 7 days after vaccination were recorded. Among 443 children <12 months of age admitted for intussusception, most (92.3%) were children ≥ 6 months. Of the 388 children who were age-eligible to receive Rotavin-M1, 116 (29.9%) had received ≥1 dose. No intussusception cases occurred in the 1–21 days after dose 1 and one case occurred on day 21 after dose 2. Among the 45,367 children who received ≥1 dose of Rotavin-M1, 9.5% of children reported at least one AEFI after dose 1 and 7.3% after dose 2. Significantly higher AEFI rates occurred among children given Rotavin-M1 with pentavalent vaccines (Quinvaxem®, ComBE Five®) compared to Rotavin-M1 without pentavalent vaccines. There was no association between intussusception and Rotavin-M1. The vaccine was generally safe when administered alone and when co-administered with other vaccines.
Keywords: rotavirus; intussusception; Rotavin-M1 vaccine; safety; adverse events following immunization (AEFI) rotavirus; intussusception; Rotavin-M1 vaccine; safety; adverse events following immunization (AEFI)

Share and Cite

MDPI and ACS Style

Le, L.K.T.; Pham, T.P.T.; Mai, L.T.P.; Nguyen, Q.T.; Tran, M.P.N.; Ho, T.H.; Pham, H.H.; Le, S.V.; Hoang, H.N.; Lai, A.T.; et al. Intussusception and Other Adverse Event Surveillance after Pilot Introduction of Rotavirus Vaccine in Nam Dinh and Thua Thien Hue Provinces—Vietnam, 2017–2021. Vaccines 2024, 12, 170. https://doi.org/10.3390/vaccines12020170

AMA Style

Le LKT, Pham TPT, Mai LTP, Nguyen QT, Tran MPN, Ho TH, Pham HH, Le SV, Hoang HN, Lai AT, et al. Intussusception and Other Adverse Event Surveillance after Pilot Introduction of Rotavirus Vaccine in Nam Dinh and Thua Thien Hue Provinces—Vietnam, 2017–2021. Vaccines. 2024; 12(2):170. https://doi.org/10.3390/vaccines12020170

Chicago/Turabian Style

Le, Ly Khanh Thi, Thao Phuong Thi Pham, Le Thi Phuong Mai, Quyet Tu Nguyen, Mai Phuong Ngoc Tran, Thien Huu Ho, Hung Hoang Pham, Sanh Van Le, Ha Ngoc Hoang, Anh Tuan Lai, and et al. 2024. "Intussusception and Other Adverse Event Surveillance after Pilot Introduction of Rotavirus Vaccine in Nam Dinh and Thua Thien Hue Provinces—Vietnam, 2017–2021" Vaccines 12, no. 2: 170. https://doi.org/10.3390/vaccines12020170

APA Style

Le, L. K. T., Pham, T. P. T., Mai, L. T. P., Nguyen, Q. T., Tran, M. P. N., Ho, T. H., Pham, H. H., Le, S. V., Hoang, H. N., Lai, A. T., Huong, N. T., Nguyen, H. D., Anh, D. D., Iijima, M., Parashar, U. D., Trang, N. V., & Tate, J. E. (2024). Intussusception and Other Adverse Event Surveillance after Pilot Introduction of Rotavirus Vaccine in Nam Dinh and Thua Thien Hue Provinces—Vietnam, 2017–2021. Vaccines, 12(2), 170. https://doi.org/10.3390/vaccines12020170

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