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Vaccines, Volume 11, Issue 12

December 2023 - 134 articles

Cover Story: The efficacy of primary vaccination, boosters, and Omicron-adapted mRNA vaccines in preventing severe SARS-CoV-2 infections, hospitalizations, and deaths has been well established. However, long-term follow up data on the immune response following repeated SARS-CoV-2 vaccinations are limited. In previously infected individuals, the immune response could be affected by immune imprinting. Waning immunity after vaccination and the emergence of immune-evading variants results in breakthrough infections; the repeated exposure of vaccinated individuals to SARS-CoV-2 antigens through breakthrough infections and/or additional vaccines could modulate the immune response against the antigenic RBD domain of new variants through hybrid immune damping. This Vaccines issue publishes long-term analyses of humoral and T cell responses in healthy adults receiving multiple SARS-CoV-2 mRNA vaccines. View this paper
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Articles (134)

  • Article
  • Open Access
2 Citations
2,547 Views
20 Pages

Role of Pre-Farrow Natural Planned Exposure of Gilts in Shaping the Passive Antibody Response to Rotavirus A in Piglets

  • Deepak Kumar,
  • Amanda V. Anderson Reever,
  • Jeremy S. Pittman,
  • Nora L. Springer,
  • Kylynn Mallen,
  • Gleyder Roman-Sosa,
  • Neha Sangewar,
  • Mary C. Casey-Moore,
  • Michael D. Bowen and
  • Waithaka Mwangi
  • + 1 author

18 December 2023

Natural planned exposure (NPE) remains one of the most common methods in swine herds to boost lactogenic immunity against rotaviruses. However, the efficacy of NPE protocols in generating lactogenic immunity has not been investigated before. A longit...

  • Article
  • Open Access
4 Citations
3,210 Views
19 Pages

A CTB-SARS-CoV-2-ACE-2 RBD Mucosal Vaccine Protects Against Coronavirus Infection

  • Béla Dénes,
  • Ryan N. Fuller,
  • Wayne Kelin,
  • Tessa R. Levin,
  • Jaipuneet Gil,
  • Aaren Harewood,
  • Márta Lőrincz,
  • Nathan R. Wall,
  • Anthony F. Firek and
  • William H. R. Langridge

18 December 2023

Mucosal vaccines protect against respiratory virus infection by stimulating the production of IgA antibodies that protect against virus invasion of the mucosal epithelium. In this study, a novel protein subunit mucosal vaccine was constructed for pro...

  • Brief Report
  • Open Access
3 Citations
2,199 Views
9 Pages

SARS-CoV-2 Humoral Immunity Persists Following Rituximab Therapy

  • Liangjian Lu,
  • Chang Yien Chan,
  • Yi Yang Lim,
  • Mya Than,
  • Sharon Teo,
  • Perry Y. W. Lau,
  • Kar Hui Ng and
  • Hui Kim Yap

18 December 2023

Long-term humoral immunity is mediated by short-lived plasma cells (replenished by memory B cells) and long-lived plasma cells. Their relative contributions are uncertain for immunity to SARS-CoV-2, especially given the widespread use of novel mRNA v...

  • Article
  • Open Access
1 Citations
2,678 Views
16 Pages

Safety and Immunogenicity of an In Vivo Muscle Electroporation Delivery System for DNA-hsp65 Tuberculosis Vaccine in Cynomolgus Monkeys

  • Monique Ribeiro de Lima,
  • Ana Cristina C. S. Leandro,
  • Andreia Lamoglia de Souza,
  • Marcio Mantuano Barradas,
  • Eric Henrique Roma,
  • Ana Teresa Gomes Fernandes,
  • Gabrielle Galdino-Silva,
  • Joyce Katiuccia M. Ramos Carvalho,
  • Renato Sergio Marchevsky and
  • Janice M. C. Oliveira Coelho
  • + 4 authors

18 December 2023

A Bacille Calmette–Guérin (BCG) is still the only licensed vaccine for the prevention of tuberculosis, providing limited protection against Mycobacterium tuberculosis infection in adulthood. New advances in the delivery of DNA vaccines b...

  • Review
  • Open Access
31 Citations
11,654 Views
26 Pages

HBV Vaccines: Advances and Development

  • Faisal Mahmood,
  • Ruixian Xu,
  • Maher Un Nisa Awan,
  • Yuzhu Song,
  • Qinqin Han,
  • Xueshan Xia,
  • Jia Wei,
  • Jun Xu,
  • Juan Peng and
  • Jinyang Zhang

18 December 2023

Hepatitis B virus (HBV) infection is a global public health problem that is closely related to liver cirrhosis and hepatocellular carcinoma (HCC). The prevalence of acute and chronic HBV infection, liver cirrhosis, and HCC has significantly decreased...

  • Article
  • Open Access
2 Citations
2,505 Views
23 Pages

17 December 2023

Toll-like receptors (TLRs) are crucial to the innate immune response. They regulate inflammatory reactions by initiating the production of pro-inflammatory cytokines and chemokines. TLRs also play a role in shaping the adaptive immune responses. Whil...

  • Article
  • Open Access
10 Citations
3,057 Views
18 Pages

The Production of Recombinant African Swine Fever Virus Lv17/WB/Rie1 Strains and Their In Vitro and In Vivo Characterizations

  • Stefano Petrini,
  • Cecilia Righi,
  • István Mészáros,
  • Federica D’Errico,
  • Vivien Tamás,
  • Michela Pela,
  • Ferenc Olasz,
  • Carmina Gallardo,
  • Jovita Fernandez-Pinero and
  • Eszter Göltl
  • + 3 authors

17 December 2023

Lv17/WB/Rie1-Δ24 was produced via illegitimate recombination mediated by low-dilution serial passage in the Cos7 cell line and isolated on PAM cell culture. The virus contains a huge ~26.4 Kb deletion in the left end of its genome. Lv17/WB/Rie1...

  • Article
  • Open Access
2 Citations
3,251 Views
15 Pages

Occurrence and Risk Factors of Relapse Activity after Vaccination against COVID-19 in People with Multiple Sclerosis: 1-Year Follow-Up Results from a Nationwide Longitudinal Observational Study

  • Firas Fneish,
  • Niklas Frahm,
  • Melanie Peters,
  • David Ellenberger,
  • Judith Haas,
  • Micha Löbermann,
  • Dieter Pöhlau,
  • Anna-Lena Röper,
  • Sarah Schilling and
  • Alexander Stahmann
  • + 3 authors

16 December 2023

Several studies reported post-SARS-CoV-2-vaccination (PV) symptoms. Even people with multiple sclerosis (PwMS) have concerns about disease activity following the SARS-CoV-2 vaccination. We aimed to determine the proportion of PwMS with PV relapses, t...

  • Article
  • Open Access
7 Citations
3,873 Views
15 Pages

Biological Characteristics of Feline Calicivirus Epidemic Strains in China and Screening of Broad-Spectrum Protective Vaccine Strains

  • Longlong Cao,
  • Jian Liu,
  • Yongfan Li,
  • Denglong Xie,
  • Quanhui Yan,
  • Qiuyan Li,
  • Yiran Cao,
  • Wenxin Du,
  • Jiakang Li and
  • Zijun Ye
  • + 3 authors

15 December 2023

Feline calicivirus (FCV) is one of the most important pathogens causing upper respiratory tract diseases in cats, posing a serious health threat to these animals. At present, FCV is mainly prevented through vaccination, but the protective efficacy of...

  • Article
  • Open Access
1 Citations
3,773 Views
12 Pages

A Novel, Comprehensive A129 Mouse Model for Investigating Dengue Vaccines and Evaluating Pathogenesis

  • Mya Myat Ngwe Tun,
  • Khine Mya Nwe,
  • Jean Claude Balingit,
  • Yuki Takamatsu,
  • Shingo Inoue,
  • Basu Dev Pandey,
  • Takeshi Urano,
  • Michinori Kohara,
  • Kyoko Tsukiyama-Kohara and
  • Kouichi Morita

15 December 2023

In search of a mouse model for use in evaluating dengue vaccines, we assessed A129 mice that lacked IFN-α/β receptors, rendering them susceptible to dengue virus (DENV) infection. To our knowledge, no reports have evaluated dengue vaccine...

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Vaccines - ISSN 2076-393X