Vitamins, Antioxidants, and Neurodegeneration: Exploring Protective Strategies in Brain Health
A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".
Deadline for manuscript submissions: 31 October 2025 | Viewed by 63
Special Issue Editor
2. Clinical Pathology and Clinical Biochemistry, Graduate School, Faculty of Medicine, University of Tor Vergata, 00133 Rome, Italy
Interests: clinical biochemistry; COVID; nutrition; vitamins; inflammation; neuroscience; neurodegenerative diseases; CSF indexes; blood morphology
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS), represent a growing global health challenge, particularly in aging populations. These conditions are characterized by the progressive loss of neuronal structure and function, leading to cognitive decline, motor impairments, and, ultimately, a significant reduction in the quality of life. Despite decades of research, the underlying mechanisms of neurodegeneration remain incompletely understood, and effective therapeutic strategies are still limited.
In recent years, there has been increasing interest in the potential roles of vitamins and antioxidants in mitigating the processes that drive neurodegeneration. Vitamins, such as vitamin E, vitamin D, and the B-complex vitamins, have been shown to play critical roles in maintaining neuronal health, modulating inflammation, and supporting metabolic functions. Similarly, antioxidants, including glutathione, coenzyme Q10, and polyphenols, are known to combat oxidative stress—a key contributor to neuronal damage and cell death in neurodegenerative diseases.
This Special Issue, titled "Vitamins, Antioxidants, and Neurodegeneration: Exploring Protective Strategies in Brain Health", aims to bring together cutting-edge research and reviews that explore the interplay between these essential nutrients and neurodegenerative processes. We invite contributions that investigate the molecular mechanisms by which vitamins and antioxidants exert their protective effects, as well as clinical studies evaluating their potential as preventive or therapeutic agents. By fostering a deeper understanding of these relationships, we hope to pave the way for novel interventions that can improve brain health and combat the devastating impact of neurodegenerative diseases.
We welcome original research articles, reviews, and perspectives that address topics such as the following:
- The role of vitamins in modulating neuroinflammation and oxidative stress.
- The impact of antioxidants on mitochondrial function and neuronal survival.
- Clinical trials investigating the efficacy of vitamin and antioxidant supplementation in neurodegenerative diseases.
- Novel delivery systems for enhancing the bioavailability of neuroprotective nutrients.
- The interplay between diet, genetics, and environmental factors in neurodegeneration.
- Through this collection of work, we aim to highlight the latest advancements in the field and inspire further research into the potential of vitamins and antioxidants as powerful tools in the fight against neurodegeneration.
Dr. Maria Morello
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- neurodegenerative diseases
- alzheimer's disease
- parkinson's disease
- amyotrophic lateral sclerosis (ALS)
- aging populations
- vitamins
- antioxidants
- oxidative stress
- neuroinflammation
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