Natural Antioxidants: Multiple Mechanisms for Skin Protection and Skin Disease
A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".
Deadline for manuscript submissions: 30 November 2026 | Viewed by 3800
Special Issue Editors
Interests: bioactive natural products; anti-aging; nutraceuticals; cosmeceuticals
Special Issues, Collections and Topics in MDPI journals
2. Department of Pathobiological Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA 70803, USA
Interests: skin health and diseases; carcinogenesis; inflammation; dermatology; psoriasis; atopic dermatitis; bioactive natural products; antioxidants; polyphenols; flavonoids; tissue engineering; signaling pathways; pharmacology
Special Issue Information
Dear Colleagues,
Human skin is the largest organ, covering the body and protecting us against environmental insults. Although it is a robust defensive system, the skin can be susceptible to both internal stress (e.g., oxidation, glycation, and inflammation) and external stimuli, including mechanical damage, ultraviolet (UV) radiation, toxic chemicals, and the invasion of microorganisms. These factors can collectively undermine the structural integrity and biological functions of the skin, which leads to skin aging, dysfunction, and other undesired conditions associated with skin health. To ameliorate these insults to the skin, natural antioxidants (e.g., phytochemicals from medicinal plants and functional foods, as well as their synthetic derivatives) have been used as treatments for dermatological maladies and/or active ingredients for cosmetic products. The skin protective effects of natural antioxidants are supported by numerous published preclinical studies (with in vitro and in vivo experimental models). However, only a paucity of human clinical trials has reported the efficacy of natural products’ skin protection and therapeutics. This is, at least partially, attributed to the lack of understanding of natural antioxidants’ mechanisms of action (MOA) at the molecular level. In recent decades, mechanistic studies on the skin protection of natural antioxidants have been greatly promoted by various advanced biophysical and biochemical technologies, which have enabled researchers in this field to address research challenges with novel approaches. For instance, sophisticated methods, such as ‘multi-omics’, including genomics, epigenomics, proteomics, lipidomics, metabolomics, and microbiomics, are adopted to provide an integrated perspective to power investigation across multiple levels of biology.
Herein, this Special Issue, titled “Natural Antioxidants: Multiple Mechanisms for Skin Protection and Skin Disease”, aims to provide a platform for researchers to showcase their studies in fields related to skin protection and disease treatment by natural and synthetic antioxidants. This Special Issue includes (but is not limited to) the following research topics: (1) evaluations of natural and synthetic antioxidants’ skin protective and therapeutic effects; (2) the investigation of mechanisms of action; (3) the development of natural antioxidants and their derivatives as new cosmeceutical ingredients; (4) the applications of ‘multi-omics’ approaches; and (5) the discovery of the molecular target(s) of action.
Dr. Hang Ma
Dr. Jean Christopher Chamcheu
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- natural products
- mechanism(s) of action
- multi-omics approaches
- target identification
- dermatological treatment
- skin protection
- inflammation
- skin cancers
- skin aging
- cosmeceuticals
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