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Brain Sci., Volume 9, Issue 9 (September 2019)
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Cover Story (view full-size image) The possibility to detect the earliest clinical manifestations of Alzheimer’s disease, in order to [...] Read more. The possibility to detect the earliest clinical manifestations of Alzheimer’s disease, in order to proceed to a biomarker based diagnosis even before the stage of mild cognitive impairment (MCI), represents a major goal, since it would offer the opportunity to have a timely access disease-modifying drugs. In a recent systematic review and meta-analysis, it has been shown that individuals with subtle cognitive decline (“pre-MCI”) with AD biomarker positivity - pre-MCI due to AD - have a high risk of progression to MCI or dementia, similar to what observed for MCI due to AD (Parnetti et al., 2019). In this review, we further focus on this issue, giving more details about neuropsychological profile, its association with biomarkers and neuropathological picture. View this paper.