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Open AccessArticle

Effects of Transpulmonary Administration of Caffeine on Brain Activity in Healthy Men

Department of Mechanical Engineering, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan
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Brain Sci. 2019, 9(9), 222; https://doi.org/10.3390/brainsci9090222
Received: 7 July 2019 / Revised: 31 August 2019 / Accepted: 1 September 2019 / Published: 3 September 2019

The present study aimed to examine the effect of transpulmonary administration of caffeine on working memory and related brain functions by electroencephalography measurement. The participants performed working memory tasks before and after vaporizer-assisted aspiration with inhalation of caffeinated- and non-caffeinated liquids in the caffeine and sham conditions, respectively. Transpulmonary administration of caffeine tended to increase the rate of correct answers. Moreover, our findings suggest that transpulmonary administration of caffeine increases the theta-band activity in the right prefrontal, central, and temporal areas during the task assigned post-aspiration. Our results may indicate an efficient and fast means of eliciting the stimulatory effects of transpulmonary administration of caffeine. View Full-Text
Keywords: caffeine; transpulmonary administration; working memory; electroencephalography; prefrontal cortex caffeine; transpulmonary administration; working memory; electroencephalography; prefrontal cortex
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Ueda, K.; Nakao, M. Effects of Transpulmonary Administration of Caffeine on Brain Activity in Healthy Men. Brain Sci. 2019, 9, 222.

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