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Brain Sciences, Volume 15, Issue 7

2025 July - 111 articles

Cover Story: In this study, we focus on indicators of psychosocial adjustment (PSA) in patients with Multiple Sclerosis (MS), examining how fatigue and disease progression negatively impact quality of life (QoL) and depressiveness. Using patient-reported outcomes, we identified depressiveness and physical, mental, and subjective QoL as key indicators of PSA in MS. Fatigue, both cognitive and motor, emerges as a central predictor of PSA in MS. To unravel the impact of disease trajectory on PSA, a comparison with patients with Amyotrophic Lateral Sclerosis (ALS) was performed, revealing both similarities and differences in mental well-being as one indicator of PSA, i.e., slower disease progression in MS may facilitate more favorable PSA. These findings emphasize the need for tailored psychotherapeutic interventions to facilitate psychosocial adjustment even in the face of severe physical challenges. View this paper
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Articles (111)

  • Article
  • Open Access
939 Views
11 Pages

The Effects of Carotid Pathologies on Short-Term Functional Outcomes After First-Ever Small Vessel Occlusion Stroke

  • Minwook Bae,
  • Yong-Suk Jeong,
  • Sopheak Phoung,
  • Phoeuk Borei,
  • Dahyeon Koo and
  • Dougho Park

Background: While carotid pathologies are well-established risk factors for stroke, their specific effects on outcomes following stroke that cannot be classified as atherosclerotic remain unclear. In this study, we aimed to determine whether carotid...

  • Article
  • Open Access
1 Citations
1,204 Views
23 Pages

Background: The brain is never truly at rest. Even in the absence of external tasks, it remains active, continuously organizing itself into large-scale resting-state networks involved in shaping our internal thoughts and experiences. Understanding th...

  • Article
  • Open Access
1,077 Views
12 Pages

Introduction: The important factor in applying substances for inner ear therapy is the atraumatic execution, as well as effective concentration uniformly distributed in all regions of the cochlea within a reasonable time frame. This study investigate...

  • Article
  • Open Access
2 Citations
981 Views
17 Pages

Background/Objectives: The prognostic uncertainty of Mild Cognitive Impairment (MCI) imposes comprehensive neuropsychological evaluations beyond mere memory assessment. However, previous investigations into other cognitive domains, such as attention,...

  • Article
  • Open Access
1 Citations
1,400 Views
23 Pages

Elucidating White Matter Contributions to the Cognitive Architecture of Affective Prosody Recognition: Evidence from Right Hemisphere Stroke

  • Meyra S. Jackson,
  • Yuto Uchida,
  • Shannon M. Sheppard,
  • Kenichi Oishi,
  • Ciprian Crainiceanu,
  • Argye E. Hillis and
  • Alexandra Z. Durfee

Background/Objectives: Successful discourse relies not only on linguistic but also on prosodic information. Difficulty recognizing emotion conveyed through prosody (receptive affective aprosodia) following right hemisphere stroke (RHS) significantly...

  • Systematic Review
  • Open Access
4 Citations
4,370 Views
23 Pages

Intraoperative Neurophysiological Monitoring in Contemporary Spinal Surgery: A Systematic Review of Clinical Outcomes and Cost-Effectiveness

  • Luca Zanin,
  • Laura Broglio,
  • Pier Paolo Panciani,
  • Riccardo Bergomi,
  • Giorgia De Rosa,
  • Luca Ricciardi,
  • Giusy Guzzi,
  • Alessandro Fiorindi,
  • Carlo Brembilla and
  • Marco Maria Fontanella
  • + 3 authors

Background: Intraoperative neurophysiological monitoring (IONM) is increasingly used during spinal surgery to reduce the risk of neurological complications. This systematic review evaluates both the clinical outcomes and cost-effectiveness of IONM in...

  • Review
  • Open Access
1,730 Views
22 Pages

Neurobiology of Dystonia: Review of Genetics, Animal Models, and Neuroimaging

  • Jamir Pitton Rissardo,
  • Andrew McGarry,
  • Yiwen Shi,
  • Ana Leticia Fornari Caprara and
  • Ian M. Walker

Over the past decade, substantial progress has been made in understanding the pathophysiology of dystonia. The number of identified genes has surged—exceeding 400 by 2024—with approximately 76.6% linked to neurodevelopmental disorders. De...

  • Review
  • Open Access
1 Citations
2,206 Views
13 Pages

Sleep and Risk of Multiple Sclerosis: Bridging the Gap Between Inflammation and Neurodegeneration via Glymphatic Failure

  • Mariateresa Buongiorno,
  • Carmen Tur,
  • Darly Milena Giraldo,
  • Natalia Cullell,
  • Jerzy Krupinski,
  • Roberta Lanzillo and
  • Gonzalo Sánchez-Benavides

Epidemiological studies identified insufficient and poor-quality sleep as independent risk factors for multiple sclerosis (MS). The glymphatic system, active during slow-wave sleep, clears brain waste through perivascular astrocytic aquaporin-4 (AQP4...

  • Article
  • Open Access
1,540 Views
19 Pages

Objectives: To investigate whether a Multimodal Rehabilitation Program (MRP) affects the change in visual–spatial abilities, especially attention, information-processing speed, visual–spatial learning, the severity of depression, and stra...

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Brain Sci. - ISSN 2076-3425