Special Issue "Vascular Cognitive Impairment and Dementia Focused on Subcortical Small Vessel Disease"
A special issue of Brain Sciences (ISSN 2076-3425).
Deadline for manuscript submissions: closed (30 November 2019).
Interests: the challenge of cognitive medicine; observational studies in patients seeking help for memory complaints, Alzheimer’s disease; vascular cognitive impairment; cerebral small vessel disease; white matter changes, cerebrospinal fluid markers; magnetic resonance imaging; assessment of cognitive impairment
The most important research advance in the field of vascular cognitive impairment and dementia in the last decade has been the scientific demonstration that age-related white matter involvement is a sign of subcortical small-vessel disease (SSVD) that leads to cognitive failure and impaired functional capacity. The advances comprise increased knowledge of the symptom profile of the disorder, the relationship between white matter involvement and reduced cerebral blood flow using MRI, the deviations of cerebrospinal fluid markers reflecting subcortical degeneration, inflammation and extracellular matrix breakdown, the potential importance of deep vein collagenosis, the clinical and pathological criteria, and the associations between SSVD and normal pressure hydrocephalus. Although several of the new findings need to be tested in new studies, they already now imply that focusing on SSVD using various approaches is a promising way of addressing the great challenge of preventing and treating age-related cognitive impairment. Future studies investigating the relationships between sporadic SSVD and genetic factors are needed as well as research on various mechanisms of causation. The intriguing issues of the relationship between SSVD and Alzheimer’s disease (AD) on one hand and stroke on the other need also to be clarified. These goals aim primarily at finding targets for intervention in patients with SSVD early in the course of the disease but may also have positive consequences for the treatment of AD and stroke.
The upcoming issue will highlight the most recent advances in clinical presentation, diagnostic markers, pathogenetic pathways, co-morbid conditions and therapeutic options of SSVD.
Prof. Dr. Anders Wallin
Prof. Dr. Gustavo C. Roman
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Brain Sciences is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- cerebral small vessel disease
- age-related white matter changes
- cognitive impairment
- clinical trials