Next Article in Journal
Using an Overlapping Time Interval Strategy to Study Diagnostic Instability in Mild Cognitive Impairment Subtypes
Previous Article in Journal
Fumaric Acids Do Not Directly Influence Gene Expression of Neuroprotective Factors in Highly Purified Rodent Astrocytes
Previous Article in Special Issue
Magnitude of Reduction and Speed of Remission of Suicidality for Low Amplitude Seizure Therapy (LAP-ST) Compared to Standard Right Unilateral Electroconvulsive Therapy: A Pilot Double-Blinded Randomized Clinical Trial
Open AccessArticle

Genetic Predisposition and Disease Expression of Bipolar Disorder Reflected in Shape Changes of the Anterior Limbic Network

1
Department of Biomedical Imaging and Radiological Sciences, National Yang-Ming University, Taipei 11221, Taiwan
2
Institute of Biophotonics, National Yang-Ming University, Taipei 11221, Taiwan
3
Brain Research Center, National Yang-Ming University, Taipei 11221, Taiwan
4
The Neurological Institute, Taipei Municipal Gan-Dau Hospital, Taipei 11260, Taiwan
5
Department of Neurology, Taipei Veterans General Hospital, Taipei 11217, Taiwan
6
Department of Psychiatry, Taipei Veterans General Hospital, Taipei 11217, Taiwan
7
Department of Medical Education and Research, Taipei Veterans General Hospital, Taipei 11217, Taiwan
8
Division of Psychiatry, Faculty of Medicine, National Yang-Ming University, Taipei 11221, Taiwan
9
Department of Psychiatry, Cheng-Hsin General Hospital, Taipei 11220, Taiwan
10
Institute of Brain Science, National Yang-Ming University, Taipei 11221, Taiwan
*
Authors to whom correspondence should be addressed.
Brain Sci. 2019, 9(9), 240; https://doi.org/10.3390/brainsci9090240
Received: 29 July 2019 / Revised: 13 September 2019 / Accepted: 16 September 2019 / Published: 19 September 2019
Bipolar disorder (BD) is a genetically and phenotypically complex psychiatric disease. Although previous studies have suggested that the relatives of BD patients have an increased risk of experiencing affective disturbances, most relatives who have similar genotypes may not manifest the disorder. We aim to identify the neuroimaging alterations—specifically, the cortical folding structures of the anterior limbic network (ALN)—in BD patients and their siblings, compared to healthy controls. The shared alterations in patients and their siblings may indicate the hereditary predisposition of BD, and the altered cortical structures unique to BD patients may be a probe of BD expression. High-resolution, T1-weighted magnetic resonance images for 17 euthymic patients with BD, 17 unaffected siblings of BD patients, and 22 healthy controls were acquired. We categorized the cortical regions within the ALN into sulcal and gyral areas, based on the shape index, followed by the measurement of the folding degree, using the curvedness. Our results revealed that the changes in cortical folding in the orbitofrontal and temporal regions were associated with a hereditary predisposition to BD. Cortical folding structures in multiple regions of the ALN, particularly in the striatal–thalamic circuit and anterior cingulate cortex, could be used to differentiate BD patients from healthy controls and unaffected siblings. We concluded that the cortical folding structures of ALN can provide potential biomarkers for clinical diagnosis of BD and differentiation from the unaffected siblings. View Full-Text
Keywords: bipolar disorder; hereditary predisposition; cortical folding structures; anterior limbic network; shape index; curvedness bipolar disorder; hereditary predisposition; cortical folding structures; anterior limbic network; shape index; curvedness
Show Figures

Figure 1

MDPI and ACS Style

Lu, C.-F.; Wu, Y.-T.; Teng, S.; Wang, P.-S.; Tu, P.-C.; Su, T.-P.; Jao, C.-W.; Li, C.-T. Genetic Predisposition and Disease Expression of Bipolar Disorder Reflected in Shape Changes of the Anterior Limbic Network. Brain Sci. 2019, 9, 240.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop