Special Issue "Frontiers in Parkinson’s Disease (PD)"
Deadline for manuscript submissions: closed (10 November 2019).
Parkinson’s Disease (PD) is the most common motor deteriorating neurodegenerative disease with a majority of cases being sporadic in nature. Over the past decade, researchers have begun to understand the physiological roles of different proteins that are mutated in monogenic forms of PD. These insights provide information into what types of biological processes may go awry in sporadic PD and aid in our understanding of the pathophysiological changes occuring during degenerative processes. The effort of multiple research groups elucidated the mechanism by which PINK1 and Parkin (two genes mutated in recessive PD) target damaged mitochondria for autophagic removal. Recently, the substrates and phorphosylation sites for leucine-rich repeat kinase 2 (LRRK2) have been identified. LRRK2 is the gene most commonly mutated in autosomal dominant forms of PD.
Newly published large-scale genome wide association studies (GWAS) have identified risk loci and candidate genes that are also involved in PD. It is imperitive that research efforts identify the function of these newly identified canidate genes (if unknown) and how these genes possibly contribute to neurodegeneration. The aim of this Special Issue, “Frontiers in Parkinson’s Disease,” is to encourage the publication of new experimental, translational and clinical findings to advance our understanding of the pathophysiological changes that occur in Parkinson’s Disease.
Assist. Prof. Alicia M. Pickrell
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Brain Sciences is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- Parkinson’s disease
- Dopaminergic neurons
- Substantia nigra