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Brain Sciences, Volume 9, Issue 8

August 2019 - 35 articles

Cover Story: Alzheimer's disease is a neurological disorder characterized by brain cell death, memory loss and cognitive decline. The porpouse of this work was to study the transcriptional profile in cells of neuroblastoma differentiated with retinoic acid, exposed to Aβ1-42 and subsequently treated with α-tocopherol. The results of the transcriptomic analysis showed that the treatment of α-tocopherol upregulated the genes involved in processing the APP through the non-amyloidogenic pathway. Furthermore, α-tocopherol modulated the expression of genes involved in autophagy by degrading the autophagosomes. In addition, α-tocopherol downregulated some cell cycle markers, such as cyclins and cyclin-dependent kinases and markers of DNA replication. Immunohistochemistry has shown that treatment with α-tocopherol was also able to reduce oxidative stress. View this paper.
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Articles (35)

  • Case Report
  • Open Access
6 Citations
4,820 Views
6 Pages

Syncope as Initial Presentation in an Undifferentiated Type Acute Myeloid Leukemia Patient with Acute Intracranial Hemorrhage

  • Meng-Yu Wu,
  • Ching-Hsiang Lin,
  • Yueh-Tseng Hou,
  • Po-Chen Lin,
  • Giou-Teng Yiang,
  • Yueh-Cheng Tien and
  • Hsiao-Ching Yeh

20 August 2019

Intracranial hemorrhage (ICH) is a catastrophic complication in patients with acute myeloid leukemia (AML). AML cells, especially in the acute promyelocytic leukemia subtype, may release microparticles (MPs), tissue factor (TF), and cancer procoagula...

  • Article
  • Open Access
7 Citations
4,155 Views
15 Pages

Entropy Analysis of High-Definition Transcranial Electric Stimulation Effects on EEG Dynamics

  • Diego C. Nascimento,
  • Gabriela Depetri,
  • Luiz H. Stefano,
  • Osvaldo Anacleto,
  • Joao P. Leite,
  • Dylan J. Edwards,
  • Taiza E. G. Santos and
  • Francisco Louzada Neto

20 August 2019

A foundation of medical research is time series analysis—the behavior of variables of interest with respect to time. Time series data are often analyzed using the mean, with statistical tests applied to mean differences, and has the assumption...

  • Article
  • Open Access
20 Citations
3,793 Views
20 Pages

20 August 2019

The genetic relationships between different behaviors used to index the aversive effects of ethanol are unknown. To address this issue, ethanol-induced conditioned place aversion (CPA) was tested in a genetically diverse panel of 15 inbred mouse stra...

  • Article
  • Open Access
20 Citations
5,056 Views
8 Pages

Pro-Nerve Growth Factor Induces Activation of RhoA Kinase and Neuronal Cell Death

  • Marina Sycheva,
  • Jake Sustarich,
  • Yuxian Zhang,
  • Vaithinathan Selvaraju,
  • Thangiah Geetha,
  • Marla Gearing and
  • Jeganathan Ramesh Babu

19 August 2019

We have previously shown that the expression of pro-nerve growth factor (proNGF) was significantly increased, nerve growth factor (NGF) level was decreased, and the expression of p75NTR was enhanced in Alzheimer’s disease (AD) hippocampal sampl...

  • Article
  • Open Access
10 Citations
3,925 Views
15 Pages

Corticospinal-Evoked Responses from the Biceps Brachii during Arm Cycling across Multiple Power Outputs

  • Evan J. Lockyer,
  • Katarina Hosel,
  • Anna P. Nippard,
  • Duane C. Button and
  • Kevin E. Power

19 August 2019

Background: We examined corticospinal and spinal excitability across multiple power outputs during arm cycling using a weak and strong stimulus intensity. Methods: We elicited motor evoked potentials (MEPs) and cervicomedullary motor evoked potential...

  • Article
  • Open Access
14 Citations
12,496 Views
22 Pages

How Therapeutic Tapping Can Alter Neural Correlates of Emotional Prosody Processing in Anxiety

  • Nicola König,
  • Sarah Steber,
  • Josef Seebacher,
  • Quinten von Prittwitz,
  • Harald R. Bliem and
  • Sonja Rossi

19 August 2019

Anxiety disorders are the most common psychological disorders worldwide resulting in a great demand of adequate and cost-effective treatment. New short-term interventions can be used as an effective adjunct or alternative to pharmaco- and psychothera...

  • Article
  • Open Access
10 Citations
4,446 Views
9 Pages

Effects of Sound-Pressure Change on the 40 Hz Auditory Steady-State Response and Change-Related Cerebral Response

  • Eishi Motomura,
  • Koji Inui,
  • Yasuhiro Kawano,
  • Makoto Nishihara and
  • Motohiro Okada

16 August 2019

The auditory steady-state response (ASSR) elicited by a periodic sound stimulus is a neural oscillation recorded by magnetoencephalography (MEG), which is phase-locked to the repeated sound stimuli. This ASSR phase alternates after an abrupt change i...

  • Communication
  • Open Access
12 Citations
3,916 Views
10 Pages

Adjunct Diagnostic Value of Transcranial Magnetic Stimulation in Mucopolysaccharidosis-Related Cervical Myelopathy: A Pilot Study

  • Mariagiovanna Cantone,
  • Giuseppe Lanza,
  • Alice Le Pira,
  • Rita Barone,
  • Giovanni Pennisi,
  • Rita Bella,
  • Manuela Pennisi and
  • Agata Fiumara

14 August 2019

Background: Cervical myelopathy (CM) is a common cause of morbidity and disability in patients with mucopolysaccharidosis (MPS) and, therefore, early detection is crucial for the best surgical intervention and follow-up. Transcranial magnetic stimula...

  • Article
  • Open Access
119 Citations
9,212 Views
14 Pages

14 August 2019

The classification recognition rate of motor imagery is a key factor to improve the performance of brain–computer interface (BCI). Thus, we propose a feature extraction method based on discrete wavelet transform (DWT), empirical mode decomposit...

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Brain Sci. - ISSN 2076-3425