Brain Sci., Volume 9, Issue 8 (August 2019) – 35 articles
Cover Story (view full-size image): Alzheimer's disease is a neurological disorder characterized by brain cell death, memory loss and cognitive decline. The porpouse of this work was to study the transcriptional profile in cells of neuroblastoma differentiated with retinoic acid, exposed to Aβ1-42 and subsequently treated with α-tocopherol. The results of the transcriptomic analysis showed that the treatment of α-tocopherol upregulated the genes involved in processing the APP through the non-amyloidogenic pathway. Furthermore, α-tocopherol modulated the expression of genes involved in autophagy by degrading the autophagosomes. In addition, α-tocopherol downregulated some cell cycle markers, such as cyclins and cyclin-dependent kinases and markers of DNA replication. Immunohistochemistry has shown that treatment with α-tocopherol was also able to reduce oxidative stress. View this paper.
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