Journal Menu► ▼ Journal Menu
Journal Browser► ▼ Journal Browser
Table of Contents
Brain Sci., Volume 9, Issue 8 (August 2019)
- Issues are regarded as officially published after their release is announced to the table of contents alert mailing list.
- You may sign up for e-mail alerts to receive table of contents of newly released issues.
- PDF is the official format for papers published in both, html and pdf forms. To view the papers in pdf format, click on the "PDF Full-text" link, and use the free Adobe Reader to open them.
Cover Story (view full-size image) Alzheimer's disease is a neurological disorder characterized by brain cell death, memory loss and [...] Read more. Alzheimer's disease is a neurological disorder characterized by brain cell death, memory loss and cognitive decline. The porpouse of this work was to study the transcriptional profile in cells of neuroblastoma differentiated with retinoic acid, exposed to Aβ1-42 and subsequently treated with α-tocopherol. The results of the transcriptomic analysis showed that the treatment of α-tocopherol upregulated the genes involved in processing the APP through the non-amyloidogenic pathway. Furthermore, α-tocopherol modulated the expression of genes involved in autophagy by degrading the autophagosomes. In addition, α-tocopherol downregulated some cell cycle markers, such as cyclins and cyclin-dependent kinases and markers of DNA replication. Immunohistochemistry has shown that treatment with α-tocopherol was also able to reduce oxidative stress. View this paper.