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Targeting the Mitochondrial Pyruvate Carrier for Neuroprotection

by Bor Luen Tang 1,2
1
Department of Biochemistry, Yong Loo Lin School of Medicine, National University Health System, Singapore 117596, Singapore
2
NUS Graduate School for Integrative Sciences and Engineering, National University of Singapore, Singapore 119077, Singapore
Brain Sci. 2019, 9(9), 238; https://doi.org/10.3390/brainsci9090238
Received: 31 August 2019 / Revised: 15 September 2019 / Accepted: 16 September 2019 / Published: 18 September 2019
(This article belongs to the Section Molecular and Cellular Neuroscience)
The mitochondrial pyruvate carriers mediate pyruvate import into the mitochondria, which is key to the sustenance of the tricarboxylic cycle and oxidative phosphorylation. However, inhibition of mitochondria pyruvate carrier-mediated pyruvate transport was recently shown to be beneficial in experimental models of neurotoxicity pertaining to the context of Parkinson’s disease, and is also protective against excitotoxic neuronal death. These findings attested to the metabolic adaptability of neurons resulting from MPC inhibition, a phenomenon that has also been shown in other tissue types. In this short review, I discuss the mechanism and potential feasibility of mitochondrial pyruvate carrier inhibition as a neuroprotective strategy in neuronal injury and neurodegenerative diseases. View Full-Text
Keywords: excitotoxicity; mitochondrial pyruvate carrier (MPC); neuroprotection; neurotoxicity; Warburg effect excitotoxicity; mitochondrial pyruvate carrier (MPC); neuroprotection; neurotoxicity; Warburg effect
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Tang, B.L. Targeting the Mitochondrial Pyruvate Carrier for Neuroprotection. Brain Sci. 2019, 9, 238.

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