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Cerebral Blood Flow Regulation in Pregnancy, Hypertension, and Hypertensive Disorders of Pregnancy

Department of Neurology, Department of Neurobiology & Anatomical Sciences, University of Mississippi Medical Center, Jackson, MS 39216, USA
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Author to whom correspondence should be addressed.
Brain Sci. 2019, 9(9), 224; https://doi.org/10.3390/brainsci9090224
Received: 16 July 2019 / Revised: 26 August 2019 / Accepted: 3 September 2019 / Published: 4 September 2019
The regulation of cerebral blood flow (CBF) allows for the metabolic demands of the brain to be met and for normal brain function including cognition (learning and memory). Regulation of CBF ensures relatively constant blood flow to the brain despite changes in systemic blood pressure, protecting the fragile micro-vessels from damage. CBF regulation is altered in pregnancy and is further altered by hypertension and hypertensive disorders of pregnancy including preeclampsia. The mechanisms contributing to changes in CBF in normal pregnancy, hypertension, and preeclampsia have not been fully elucidated. This review summarizes what is known about changes in CBF regulation during pregnancy, hypertension, and preeclampsia. View Full-Text
Keywords: cerebral blood flow; pregnancy; preeclampsia; eclampsia; chronic hypertension; superimposed preeclampsia; blood-brain barrier; autoregulation cerebral blood flow; pregnancy; preeclampsia; eclampsia; chronic hypertension; superimposed preeclampsia; blood-brain barrier; autoregulation
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Jones-Muhammad, M.; Warrington, J.P. Cerebral Blood Flow Regulation in Pregnancy, Hypertension, and Hypertensive Disorders of Pregnancy. Brain Sci. 2019, 9, 224.

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