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Life, Volume 15, Issue 5

2025 May - 150 articles

Cover Story: This article reviews the mechanisms, preclinical results, and potential clinical opportunities of sonodynamic therapy (SDT) for malignant gliomas. SDT has been reported to have a synergistic effect when combining low-intensity ultrasound with the sonosensitizer protoporphyrin IX (PpIX), leading to significant potential in the targeted treatment of high-grade gliomas. Our research of the existing literature found that the sonodynamic effect of PpIX increases tumor immunogenicity and induces apoptosis. It appears that SDT with 5-aminolevulinc acid (5-ALA)—the prodrug of PpIX—holds potential for the treatment of malignant gliomas. This review enhances our understanding of the multifaceted possibilities of SDT for brain tumor patients. View this paper
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Articles (150)

  • Review
  • Open Access
10 Citations
9,789 Views
17 Pages

A New Perspective on Overfeeding in the Intensive Care Unit (ICU): Challenges, Dangers and Prevention Methods

  • Vlad-Dimitrie Cehan,
  • Alina-Roxana Cehan,
  • Mihai Claudiu Pui and
  • Alexandra Lazar

21 May 2025

Overfeeding, currently defined as providing excessive energy and nutrients beyond metabolic requirements, is a common yet often overlooked issue in the intensive care unit (ICU) setting. Understanding the factors contributing to overfeeding and imple...

(This article belongs to the Special Issue Critical Issues in Intensive Care Medicine)
  • Article
  • Open Access
1 Citations
2,130 Views
14 Pages

21 May 2025

The chicken chorioallantoic membrane (CAM) model is an embryonic blood capillary system considered a suitable “in vivo” model for studying the irritation effect of plant extracts on the vascular system, including impacts on hemostasis, hy...

(This article belongs to the Section Animal Science)
  • Article
  • Open Access
1 Citations
1,296 Views
18 Pages

Assessment of Suitable Habitats and Identification of Key Protection Areas for Polyplectron katsumatae in Jianfengling, Hainan Province, China

  • Wutao Yao,
  • Yong Ma,
  • An Long,
  • Lixi Liu and ,
  • Erping Shang,
  • Shuyan Zhang,
  • Jin Yang and
  • Tianxiong Gao
  • + 3 authors+ 0 author

21 May 2025

Polyplectron katsumatae is a rare and endangered species endemic to Hainan, China. It has long been regarded as a subspecies of the widely distributed Grey Peacock-Pheasant (Polyplectron bicalcaratum), a classification that has resulted in a paucity...

(This article belongs to the Section Biodiversity, Ecology and Evolution)
  • Review
  • Open Access
13 Citations
5,379 Views
53 Pages

Global Occurrence of Cyanotoxins in Drinking Water Systems: Recent Advances, Human Health Risks, Mitigation, and Future Directions

  • Jerikias Marumure,
  • Willis Gwenzi,
  • Zakio Makuvara,
  • Tinoziva T. Simbanegavi and ,
  • Richwell Alufasi,
  • Marvelous Goredema,
  • Claudious Gufe,
  • Rangarirayi Karidzagundi,
  • Piotr Rzymski and
  • Dariusz Halabowski
  • + 5 authors+ 0 author

21 May 2025

This paper applies a semi-quantitative approach to review the diversity, environmental controls, detection methods, human health risks, and mitigation of cyanotoxins in drinking water systems (DWSs). It discusses the environmental factors controlling...

(This article belongs to the Special Issue Algae—a Step Forward in the Sustainability of Resources: 2nd Edition)
  • Review
  • Open Access
3 Citations
8,593 Views
21 Pages

Injectables in the Therapy of Mid-Portion Achilles Tendinopathy, a Descriptive Review

  • Daniela Poenaru,
  • Claudia Gabriela Potcovaru,
  • Miruna Ioana Sandulescu,
  • Mariana Constantinovici and
  • Delia Cinteza

21 May 2025

Achilles mid-portion tendinopathy is defined as a painful thickening of the tendon, identified also on different imagistic examinations, occurring in sport people as well in inactively middle-aged individuals. The chronic and/or relapsing evolution i...

(This article belongs to the Special Issue Orthopedic Disease Treatment and Management: Innovations, Challenges, and Future Directions)
  • Article
  • Open Access
3 Citations
1,781 Views
18 Pages

Correlation Between Sarcopenia and Oral Health in Patients on Chronic Hemodialysis

  • Petra Kovačević Totić,
  • Iva Klarić Puđa,
  • Karla Kovačević Čorak,
  • Velimir Altabas and ,
  • Milan Milošević,
  • Selma Cvijetić Avdagić and
  • Karmela Altabas
  • + 2 authors+ 0 author

21 May 2025

Patients on hemodialysis have signs of chronic systemic inflammation and a higher incidence of sarcopenia. Poor oral health can also trigger systemic inflammation and thus affect sarcopenia. The study included 100 patients on chronic hemodialysis who...

(This article belongs to the Section Medical Research)
  • Article
  • Open Access
3 Citations
1,964 Views
12 Pages

The (ProteUS) Anisotropy Effect in Deep Fascia Ultrasonography: The Impact of Probe Angulation on Echogenicity and Thickness Assessments

  • Carmelo Pirri,
  • Nina Pirri,
  • Diego Guidolin,
  • Enrico De Rose and ,
  • Veronica Macchi,
  • Andrea Porzionato,
  • Raffaele De Caro and
  • Carla Stecco
  • + 3 authors+ 0 author

21 May 2025

This study investigates the influence of probe angulation on echogenicity and thickness measurements of the deep fascia, addressing methodological challenges in musculoskeletal ultrasound examination. The anisotropic nature of connective tissues can...

(This article belongs to the Section Physiology and Pathology)
  • Article
  • Open Access
6 Citations
14,987 Views
15 Pages

21 May 2025

After COVID-19 infection, about 30% of people have clinically persisting symptoms, characterized as Post COVID-19 Condition (PCC). One of the most reported symptoms in PCC is cognitive dysfunction, yet there are only a few studies investigating long-...

(This article belongs to the Section Medical Research)
  • Article
  • Open Access
3 Citations
4,244 Views
13 Pages

Retinal Phosphenes Induced by Transorbital Electrical Stimulation: Influence of Light Adaptation, Electrode Montage, and View Direction

  • Alexander Hunold,
  • Daniela Ortega,
  • Stefanie Freitag,
  • Dietmar Link and ,
  • Andrea Antal,
  • Sascha Klee and
  • Jens Haueisen
  • + 2 authors+ 0 author

21 May 2025

In this study, the perception of phosphenes was used as a surrogate identifier for stimulation sites for use in retinal-degenerative diseases. We aimed to investigate the influence of adaptation, electrode montage, and direction of view on electrical...

(This article belongs to the Section Medical Research)
  • Article
  • Open Access
5 Citations
2,272 Views
19 Pages

20 May 2025

Fibromyalgia, one of the most challenging pains to treat, lacks impartial considerations for diagnosis and useful assessment. The core symptoms are persistent extensive pain accompanied by fatigue, psychological disorders, sleep disturbance, and obes...

(This article belongs to the Special Issue Feature Paper in Physiology and Pathology: 2nd Edition)
  • Article
  • Open Access
2 Citations
1,312 Views
16 Pages

Osteochondral Alterations in Patients Treated with Total Knee Arthroplasty Due to Rheumatoid Arthritis and Primary Osteoarthritis: Cross-Sectional Study with Focus on Elucidating Effects of Knee Malalignment

  • Andreja Baljozovic,
  • Aleksa Lekovic,
  • Slobodan Nikolic,
  • Danijela Djonic and ,
  • Marija Djuric,
  • Zoran Bascarevic and
  • Jelena Jadzic
  • + 2 authors+ 0 author

20 May 2025

Micro-computed tomography assessment of osteochondral microstructural properties of the distal femur and proximal tibia was comprehensively conducted to compare adult patients with knee rheumatoid arthritis (RA) and primary knee osteoarthritis (KOA),...

(This article belongs to the Special Issue Reconstruction of Bone Defects)
  • Article
  • Open Access
4 Citations
1,718 Views
18 Pages

20 May 2025

Retrogressive succession alters soil conditions and microbial community dynamics in cold-region wetlands, yet its ecological implications remain understudied. This study explored the structure and function of soil microbial communities across three s...

(This article belongs to the Section Microbiology)
  • Article
  • Open Access
3,797 Views
13 Pages

Impact of Neuromuscular Fatigue on Dynamic Knee Valgus in Female Basketball Players

  • Beatriz B. Gomes,
  • Ricardo Cardoso,
  • Rui A. Fernandes and
  • Rui A. Ferreira

20 May 2025

Dynamic knee valgus is a biomechanical condition often linked to an increased risk of knee injuries, particularly in female athletes, due to greater hip adduction, internal rotation, and knee abduction during dynamic movements. This study aimed to as...

(This article belongs to the Special Issue Advances in Knee Biomechanics)
  • Article
  • Open Access
1 Citations
1,535 Views
11 Pages

Prevalence and Characteristics of Patients with Cystic Fibrosis-Related Diabetes in Croatia

  • Lora Stanka Kirigin Biloš,
  • Maja Baretić,
  • Andrea Vukić Dugac,
  • Krešimir Schoenwald and ,
  • Ivan Bambir,
  • Duška Tješić Drinković,
  • Nevena Krnić and
  • Velimir Altabas
  • + 3 authors+ 0 author

20 May 2025

This study investigated the prevalence of cystic fibrosis-related diabetes (CFRD) in the Croatian cystic fibrosis (CF) population, the age at diagnosis, insulin requirements, and the relationship between age at diagnosis and other clinical parameters...

(This article belongs to the Special Issue Cystic Fibrosis: A Disease with a New Face)
  • Article
  • Open Access
2 Citations
1,529 Views
14 Pages

Impact of Left Ventricular Mass on Mortality in Symptomatic Severe Aortic Stenosis: A Sex-Specific Analysis

  • Solange Desirée Avakian,
  • Flávio Tarasoutchi and
  • Antonio de Padua Mansur

20 May 2025

Aortic stenosis (AS) is a common and serious valvular disease in older adults, often leading to increased left ventricular mass (LVM) due to pressure overload. Excessive LVM is linked to adverse outcomes, but its sex-specific prognostic significance...

(This article belongs to the Special Issue Cardiovascular Diseases: From Basic Research to Clinical Application—2nd Edition)
  • Article
  • Open Access
10 Citations
3,284 Views
14 Pages

Engineered Chlamydomonas reinhardtii Strains for Enhanced Astaxanthin Production

  • Federico Perozeni,
  • Margherita Angelini,
  • Matteo Ballottari and
  • Stefano Cazzaniga

20 May 2025

Microalgae have evolved a diverse carotenoid profile, enabling efficient light harvesting and photoprotection. Previous studies have demonstrated the feasibility of genome editing in the green algal model species Chlamydomonas reinhardtii, leading to...

(This article belongs to the Special Issue Algae—a Step Forward in the Sustainability of Resources: 2nd Edition)
  • Review
  • Open Access
8 Citations
6,845 Views
17 Pages

Milpa Diet for MASLD in Mesoamerican Populations: Feasibility, Advantages, and Future Perspectives

  • Aline Huerta-Álvarez,
  • Mariana Arellano,
  • Clyo Anahí Chávez-Méndez,
  • Paulina Carpinteyro-Espin and ,
  • Carmen Palacios-Reyes and
  • Juanita Pérez-Escobar
  • + 1 author+ 0 author

19 May 2025

Metabolic dysfunction-associated steatotic liver disease (MASLD) is the leading cause of chronic liver disease, linked closely to metabolic syndrome and rising obesity rates. Affecting up to 37% of the global adult population, MASLD prevalence is exc...

(This article belongs to the Section Epidemiology)
  • Case Report
  • Open Access
1 Citations
2,530 Views
9 Pages

Bilateral Choroidal Detachment Following Pseudophakic Cystoid Macular Edema Treatment with Oral Acetazolamide

  • Agnieszka Kudasiewicz-Kardaszewska,
  • Małgorzata Ozimek,
  • Tomasz Urbański and
  • Sławomir Cisiecki

19 May 2025

Aim: This case report presents an unusual instance of bilateral choroidal effusion following the oral administration of acetazolamide for the treatment of pseudophakic cystoid macular edema (PCME). Case Presentation: An 87-year-old Caucasian man expe...

(This article belongs to the Special Issue Vision Science and Optometry)
  • Review
  • Open Access
4 Citations
3,532 Views
16 Pages

Complex Transfemoral Access During Transcatheter Aortic Valve Replacement: A Narrative Review of Management, Complexity Scores, and Alternative Access

  • Ioannis Skalidis,
  • Neila Sayah,
  • Thierry Unterseeh,
  • Thomas Hovasse and ,
  • Francesca Sanguineti,
  • Philippe Garot,
  • Youcef Lounes,
  • Antoinette Neylon and
  • Mariama Akodad
  • + 4 authors+ 0 author

19 May 2025

Transcatheter aortic valve replacement (TAVR) has become a well-established treatment for severe aortic stenosis across all levels of surgical risk. While transfemoral access remains the default approach, complications arising from vascular access&md...

(This article belongs to the Section Medical Research)
  • Article
  • Open Access
1 Citations
1,614 Views
17 Pages

19 May 2025

The effects of proline co-solvent on helix folding are explored through the single discrete coordinate of the number of helical hydrogen bonds. The analysis is based on multi-microsecond length molecular dynamics simulations of alanine-based helix-fo...

(This article belongs to the Section Biochemistry, Biophysics and Computational Biology)
  • Systematic Review
  • Open Access
4 Citations
2,209 Views
16 Pages

19 May 2025

Background: Gestational diabetes mellitus (GDM) is a common endocrine and metabolic disorder during pregnancy. However, current studies have not reached a consensus on the correlation between GDM and the risk of developing cancers. Objective: This sy...

(This article belongs to the Section Medical Research)
  • Systematic Review
  • Open Access
3 Citations
3,606 Views
18 Pages

Viruses in Simuliidae: An Updated Systematic Review of Arboviral Diversity and Vector Potential

  • Alejandra Rivera-Martínez,
  • S. Viridiana Laredo-Tiscareño,
  • Jaime R. Adame-Gallegos,
  • Erick de Jesús de Luna-Santillana and ,
  • Carlos A. Rodríguez-Alarcón,
  • Julián E. García-Rejón,
  • Mauricio Casas-Martínez and
  • Javier A. Garza-Hernández
  • + 3 authors+ 0 author

19 May 2025

Black flies (Diptera: Simuliidae) are important vectors of pathogens, including filarial nematodes, protozoans, and arboviruses, which significantly impact human and animal health. Although their role in arbovirus transmission has not been as thoroug...

(This article belongs to the Section Epidemiology)
  • Systematic Review
  • Open Access
8 Citations
3,521 Views
32 Pages

Cardiac Manifestations and Emerging Biomarkers in Multisystem Inflammatory Syndrome in Children (MIS-C): A Systematic Review and Meta-Analysis

  • Diana-Andreea Ciortea,
  • Mădălina Nicoleta Matei,
  • Mihaela Debita,
  • Ancuța Lupu and ,
  • Mirela Mătăsaru,
  • Gabriela Isabela Verga (Răuță) and
  • Silvia Fotea
  • + 2 authors+ 0 author

19 May 2025

Background: Cardiac involvement is a key prognostic factor in multisystem inflammatory syndrome in children (MIS-C), a rare but serious inflammatory condition that typically occurs 2–6 weeks after SARS-CoV-2 infection and is characterized by fe...

(This article belongs to the Section Physiology and Pathology)
  • Article
  • Open Access
3 Citations
1,542 Views
13 Pages

Physiological Response of Citrus reticulata Blanco var. Gonggan Seedlings to High-Temperature Stress

  • Shaoping Wu,
  • Jinyan Liao,
  • Chunxing Ye,
  • Shanyi Chen and ,
  • Yingshan Wang,
  • Xiaochun Zhang,
  • Junwen Huang and
  • Cong Chen
  • + 3 authors+ 0 author

19 May 2025

The physiological and biochemical responses of Citrus reticulata Blanco var. Gonggan (Gonggan) to high-temperature stress were explored in the present study, offering valuable insights into the growth of this plant in elevated temperature scenar...

(This article belongs to the Section Plant Science)
  • Article
  • Open Access
3 Citations
2,285 Views
22 Pages

Hypoglycemic, Antioxidant Activities, and Probiotic Characteristics of Lacticaseibacillus rhamnosus LBUX2302 Isolated from Stool Samples of Neonates

  • Pedro A. Reyes-Castillo,
  • Ana Laura Esquivel-Campos,
  • Edgar Torres-Maravilla,
  • Eduardo Zúñiga-León and ,
  • Felipe Mendoza-Pérez,
  • Rosa González-Vázquez,
  • María Guadalupe Córdova-Espinoza,
  • María Angélica Gutiérrez-Nava,
  • Raquel González-Vázquez and
  • Lino Mayorga-Reyes
  • + 5 authors+ 0 author

18 May 2025

Lacticaseibacillus species have shown potential in managing hyperglycemia, hypercholesterolemia, and oxidative stress, depending on the strain and species. This study aimed to isolate a novel Lacticaseibacillus rhamnosus strain from healthy newborns...

(This article belongs to the Collection Isolation and Characterization of New Microbial Species and Strains)
  • Article
  • Open Access
4 Citations
1,778 Views
15 Pages

Exploring the Link Between Nutritional and Functional Status and Short-Term Postoperative Outcomes in Patients Undergoing Pancreatic Cancer Surgery

  • Irene Lidoriki,
  • Maximos Frountzas,
  • Eva Karanikki,
  • Adam Mylonakis and ,
  • Alexandros Kozadinos,
  • Iliana Tsikrikou,
  • Maria Kyriakidou,
  • Lysandros Karydakis,
  • Dimitrios Stefanoudakis and
  • Dimitrios Schizas
  • + 9 authors+ 4 authors

18 May 2025

Background: Patients with pancreatic cancer are at increased risk of malnutrition and functional decline. This study aimed to identify preoperative nutritional and functional risk factors associated with postoperative complications. Methods: Adult pa...

(This article belongs to the Section Medical Research)
  • Article
  • Open Access
7 Citations
3,006 Views
12 Pages

Empagliflozin Leads to Faster Improvement in Arterial Stiffness Compared to Dapagliflozin: A Double-Blind Clinical

  • Erick González Campos,
  • Fernando Grover Páez,
  • Carlos Gerardo Ramos Becerra,
  • Luis Ricardo Balleza Alejandri and ,
  • Daniel Osmar Suárez Rico,
  • Ernesto Germán Cardona Muñoz,
  • Sara Pascoe González,
  • María Guadalupe Ramos Zavala,
  • Alberto Beltrán Ramírez and
  • David Cardona Müller
  • + 6 authors+ 1 author

18 May 2025

(1) Background: Arterial stiffness, often measured by carotid–femoral pulse wave velocity (cf-PWV), is crucial in cardiovascular disease. Dapagliflozin has shown rapid effects on arterial stiffness, but there is limited evidence of empagliflozi...

(This article belongs to the Special Issue Advances in Vascular Health and Metabolism)
  • Article
  • Open Access
3 Citations
2,378 Views
12 Pages

The Effect of Pupil Size on Cone Contrast Sensitivity

  • Ali Almustanyir,
  • Meznah S. Almutairi,
  • Amal Aldrwish,
  • Nabeela Hasrod and ,
  • Bader A. Alqhtani,
  • Tahani Alqahtani,
  • Muteb Alanazi,
  • Mansour Alghamdi,
  • Essam Almutleb and
  • Mosaad Alhassan
  • + 7 authors+ 2 authors

17 May 2025

Background: Measuring contrast sensitivity for each of the three cone types separately allows for a more precise and clinically valuable assessment of color vision. This study examined how pupil size affects cone contrast sensitivity (CCS). Methods:...

(This article belongs to the Special Issue Vision Science and Optometry)
  • Systematic Review
  • Open Access
2 Citations
7,089 Views
39 Pages

Musculoskeletal Impairments and Dysfunction in Individuals with Head and Neck Cancer Following Surgery with Neck Dissection—A Systematic Review

  • Norazlin Mohamad,
  • Ana Izabela Sobral de Oliveira-Souza,
  • Stephanie M. Ntoukas,
  • Ester Moreira de Castro-Carletti and ,
  • Munayati Munajat,
  • Liz Dennett,
  • Kerry S. Courneya,
  • Susan Armijo-Olivo and
  • Margaret L. McNeely
  • + 4 authors+ 0 author

17 May 2025

Background: Various forms of head and neck cancer (HNC) surgery that include a neck dissection procedure have been shown to negatively influence the neuromusculoskeletal function of the structures affected. This review aimed to identify the neuromusc...

(This article belongs to the Section Medical Research)
  • Review
  • Open Access
5 Citations
7,767 Views
25 Pages

Glycemic Control in Patients with Diabetes on Peritoneal Dialysis: From Glucose Sparing Approach to Glucose Monitoring

  • Aleksandra Kezić,
  • Selena Gajić,
  • Ana Račić Ostojić,
  • Ivana Bekić and ,
  • Ana Bontić,
  • Jelena Pavlović,
  • Marko Baralić and
  • Ljiljana Popović
  • + 3 authors+ 0 author

17 May 2025

Optimized glycemic management is crucial for controlling atherosclerosis and consequent cardiovascular morbidity in patients with diabetes. Due to the continuous glucose burden from glucose-containing peritoneal dialysis (PD) solutions, PD patients w...

(This article belongs to the Section Medical Research)
  • Article
  • Open Access
2 Citations
2,665 Views
27 Pages

The plk1 Gene Regulatory Network Modeling Identifies Three Circuits for plk1-mediated Genomic Instability Leading to Neoplastic Transformation

  • Jeison F. Suescum-Holguín,
  • Diana Carolina Clavijo-Buriticá,
  • Edward Fabian Carrillo-Borda and
  • Mauricio Alberto Quimbaya

17 May 2025

Genomic instability has been increasingly recognized over the past decade as a fundamental driver of cancer initiation and progression, largely owing to its association with specific genes and cellular mechanisms that offer therapeutic potential. How...

(This article belongs to the Special Issue Feature Papers in Synthetic Biology and Systems Biology 2026)
  • Communication
  • Open Access
3 Citations
2,283 Views
9 Pages

Local Therapy Can Enhance the Prognosis of Certain Patients with Pathologically Diagnosed Neuroendocrine Prostate Carcinoma

  • Shoichi Kimura,
  • Naoki Terada,
  • Shinnya Soumiya,
  • Takayuki Goto and ,
  • Hiromitsu Negoro,
  • Shoichiro Mukai,
  • Osamu Ogawa,
  • Shusuke Akamatsu,
  • Takashi Kobayashi and
  • Toshiyuki Kamoto
  • + 6 authors+ 1 author

17 May 2025

Neuroendocrine prostate cancer (NEPC) has a poor prognosis. We performed a retrospective analysis of the factors contributing to survival in patients with histologically diagnosed NEPC. Patients pathologically diagnosed with NEPC between 2007 and 201...

(This article belongs to the Special Issue Prostate Cancer: 4th Edition)
  • Article
  • Open Access
1,725 Views
15 Pages

Cloning and Spatiotemporal Expression Analysis of IGF1R Gene cDNA in Alopex lagopus (Arctic Fox)

  • Wei Xu,
  • Hualin Fu,
  • Xiangyu Meng,
  • Yiwen Sun and ,
  • Fangyong Ning and
  • Zhiheng Du
  • + 1 author+ 0 author

17 May 2025

This study aimed to clarify the sequence characteristics and spatiotemporal expression patterns of the insulin-like growth factor 1 receptor (IGF1R) gene in Alopex lagopus (Arctic fox), thereby addressing the existing knowledge gap regarding IGF1R-me...

(This article belongs to the Section Animal Science)
  • Article
  • Open Access
2 Citations
2,329 Views
13 Pages

Flaws in Estrus Synchronization Protocols Increase Vaginal Prolapse and Hydrometra Risk in Sheep

  • Nikolaos Tsekouras,
  • Ioannis Tsakmakidis,
  • Dimitrios Gougoulis,
  • Mathis A. B. Christodoulopoulos and ,
  • Christos Kousoulis,
  • Georgios I. Papakonstantinou,
  • Vasileios G. Papatsiros and
  • Georgios Christodoulopoulos
  • + 3 authors+ 0 author

17 May 2025

This study examines the reproductive outcomes of Lacaune-crossbred ewes and hoggets in intensive production systems, focusing on vaginal prolapse and hydrometra associated with flaws in estrus synchronization (E.S.) protocols. Data from multiple farm...

(This article belongs to the Section Animal Science)
  • Perspective
  • Open Access
2 Citations
2,054 Views
19 Pages

16 May 2025

The liver’s crucial role in methylglyoxal (MG) metabolism is frequently overlooked in the literature. We present a perspective that enhances the current understanding of the role of methylglyoxal (MG) and the glyoxalase cycle in the pathogenesi...

(This article belongs to the Section Physiology and Pathology)
  • Review
  • Open Access
8 Citations
11,761 Views
25 Pages

Connective Tissue Disorder-Induced Diffuse Alveolar Hemorrhage: A Comprehensive Review with an Emphasis on Airway and Respiratory Management

  • Mayuri Mudgal,
  • Swetha Balaji,
  • Ajeetha Priya Gajendiran,
  • Ananthraj Subramanya and ,
  • Shanjai Krishnan Murugan,
  • Venkatesh Gondhi,
  • Aseem Rai Bhatnagar and
  • Kulothungan Gunasekaran
  • + 3 authors+ 0 author

15 May 2025

Diffuse alveolar hemorrhage (DAH), a catastrophic complication of connective tissue disorders (CTDs), manifests as rapid-onset hypoxemia, alveolar infiltrates, and progressive bleeding into the airways. While immune-mediated alveolar–endothelia...

(This article belongs to the Section Physiology and Pathology)
  • Article
  • Open Access
4 Citations
1,782 Views
21 Pages

Isolation, Sphalerite Bioleaching, and Whole Genome Sequencing of Acidithiobacillus ferriphilus QBS3 from Zinc-Rich Sulfide Mine Drainage

  • Kan Wang,
  • Yuandong Liu,
  • Run Liu,
  • Wissal Belqadi and ,
  • Weimin Zeng,
  • Runlan Yu and
  • Xueling Wu
  • + 2 authors+ 0 author

15 May 2025

The genus Acidithiobacillus has been widely used in bioleaching, and novel strains in this genus, such as A. ferriphilus, have also been confirmed to possess bioleaching capabilities. In this study, an Acidithiobacillus ferriphilus strain, QBS3, was...

(This article belongs to the Collection Isolation and Characterization of New Microbial Species and Strains)
  • Article
  • Open Access
9 Citations
10,387 Views
26 Pages

15 May 2025

Intra-tissue endoscopy, providing real-time images at all scales, from macroscopic to microscopic, from inside living tissue during surgical procedures, has revealed the existence of a body-wide fibrillar architecture that extends from the surface of...

(This article belongs to the Section Cell Biology and Tissue Engineering)
  • Article
  • Open Access
7 Citations
5,725 Views
21 Pages

Microfluidic Sorting Can Be Applied for Assisted Reproduction Sperm Selection in Different Cases of Semen Abnormalities

  • Giulia Traini,
  • Maria Emanuela Ragosta,
  • Lara Tamburrino,
  • Alice Papini and ,
  • Sarah Cipriani,
  • Linda Vignozzi,
  • Elisabetta Baldi and
  • Sara Marchiani
  • + 3 authors+ 0 author

15 May 2025

Sperm preparation is a critical step in assisted reproduction, aiming to isolate spermatozoa with optimal characteristics and high fertilizing potential. Traditional sperm selection methods involve centrifugation, which may cause sperm damage. Microf...

(This article belongs to the Section Medical Research)
  • Article
  • Open Access
2 Citations
3,725 Views
11 Pages

Real-World Study of Tildrakizumab Survival in Psoriasis: Impact of Arthritis, Hypertension, and Prior Biologic Use

  • Raquel Santos-Juanes Galache,
  • Sebastian Reyes García,
  • Jimena Carrero Martín,
  • Álvaro Nuñez Domínguez and ,
  • Marta López Pando,
  • Irene Álvarez Losada,
  • Irene de la Fuente Villaverde,
  • Ana Lozano-Blazquez,
  • Esther Salgueiro and
  • Cristina Galache Osuna
  • + 7 authors+ 2 authors

15 May 2025

In routine clinical settings, identifying the factors that influence the persistence of biologic therapies is crucial for tailoring psoriasis management to individual patient profiles. This study aimed to evaluate the real-world drug survival of tild...

(This article belongs to the Section Physiology and Pathology)
  • Review
  • Open Access
19 Citations
7,741 Views
21 Pages

Three-Dimensional Bioprinting Techniques in Skin Regeneration: Current Insights and Future Perspectives

  • Anna Barbara Di Stefano,
  • Valentina Urrata,
  • Kim Schilders,
  • Mara Franza and ,
  • Simona Di Leo,
  • Francesco Moschella,
  • Adriana Cordova and
  • Francesca Toia
  • + 3 authors+ 0 author

15 May 2025

Skin is composed of three layers: the epidermis, dermis, and hypodermis. It is enriched with skin appendages, including hair follicles, sweat glands, and sebaceous glands, which play essential roles in regulating fluid exchange, controlling body temp...

(This article belongs to the Section Medical Research)
  • Article
  • Open Access
24 Citations
3,065 Views
18 Pages

Multifactorial Risk Stratification in Patients with Heart Failure, Chronic Kidney Disease, and Atrial Fibrillation: A Comprehensive Analysis

  • Mihai Sorin Iacob,
  • Nilima Rajpal Kundnani,
  • Abhinav Sharma,
  • Vlad Meche and ,
  • Paul Ciobotaru,
  • Ovidiu Bedreag,
  • Dorel Sandesc,
  • Simona Ruxanda Dragan,
  • Marius Papurica and
  • Livia Claudia Stanga
  • + 5 authors+ 0 author

14 May 2025

Background: Heart failure (HF), chronic kidney disease (CKD), and atrial fibrillation (AF) frequently coexist, forming a high-risk triad that amplifies morbidity and mortality through shared pathophysiological mechanisms such as neurohormonal activat...

(This article belongs to the Special Issue Interdisciplinarity in Cardiovascular Diseases: From Pathophysiology to Diagnosis and Treatment: 3rd Edition)
  • Review
  • Open Access
42 Citations
9,142 Views
23 Pages

14 May 2025

TNF-α is a pro-inflammatory cytokine that plays a pivotal role in the regulation of immune responses. It is predominantly produced by activated macrophages, although other cell types, such as T lymphocytes and NK cells, also contribute to its s...

(This article belongs to the Section Physiology and Pathology)
  • Article
  • Open Access
4 Citations
1,783 Views
16 Pages

Clinical and Paraclinical Peculiarities of SARS-CoV-2 and Influenza Infections in Children: A Comparative Study

  • Maria Oana Săsăran,
  • Carmen Viorica Muntean,
  • Andreea Bianca Stoica,
  • Carmen Schwesig and ,
  • Anca Meda Văsieșiu,
  • Anca Doina Pleșca and
  • Cristina Oana Mărginean
  • + 2 authors+ 0 author

14 May 2025

Background: SARS-CoV-2 and influenza can present with similar clinical pictures in children, with symptoms and paraclinical particularities which might aid in the differentiation of the two entities and which can be suggestive of various complication...

(This article belongs to the Special Issue Updates on Respiratory Pathologies)
  • Review
  • Open Access
18 Citations
10,109 Views
22 Pages

Multidisciplinary Telemedicine in Healthcare During and After the COVID-19 Pandemic: A Narrative Review

  • Angelica Gherman,
  • Diana Andrei,
  • Călin Marius Popoiu,
  • Emil Robert Stoicescu and ,
  • Mihaela Codrina Levai,
  • Isabella Ionela Stoian and
  • Vlad Bloancă
  • + 2 authors+ 0 author

14 May 2025

The COVID-19 pandemic accelerated the adoption of virtual multidisciplinary teams (MDTs), transforming healthcare delivery through telemedicine. This review examines the integration of telemedicine into multidisciplinary care across various medical s...

(This article belongs to the Special Issue Human Health Before, During, and After COVID-19)
  • Review
  • Open Access
3 Citations
2,172 Views
20 Pages

Can Bisphenols Alter the Inflammation Process?

  • Denis Bazany,
  • Hana Greifova,
  • Lucia Zuscikova,
  • Katarina Tokarova and ,
  • Tomas Jambor,
  • Anton Kovacik and
  • Norbert Lukac
  • + 2 authors+ 0 author

14 May 2025

This review’s main purpose is to draw attention to the possible influence of widely used bisphenols on the inflammatory process. Bisphenols are endocrine-disrupting chemicals that are produced worldwide in great quantities. From this point of v...

(This article belongs to the Special Issue Assessments of Bioactive and Toxic Substances in Cellular and Animal Models)
  • Article
  • Open Access
1,064 Views
14 Pages

Prognostic Impact of COVID-19 Inflammation Score Response: A Sub-Group Analysis on Critically Ill Patients of the RuxCoFlam Trial

  • Manfred Weiss,
  • Jakob Hammersen,
  • Sebastian Rudolphi,
  • Isabell Formann and ,
  • Karl Träger,
  • Frank G. Rücker,
  • Beate Grüner,
  • Andreas Allgöwer,
  • Sebastian Birndt and
  • Frank Stegelmann
  • + 9 authors+ 4 authors

14 May 2025

This study aims to identify parameters predicting COVID-19 inflammation score (CIS) response and survival probability in critically ill patients with hyperinflammation treated with the Janus kinase (JAK) 1/2 inhibitor ruxolitinib. This is a single ar...

(This article belongs to the Special Issue Human Health Before, During, and After COVID-19)
  • Systematic Review
  • Open Access
1 Citations
2,676 Views
15 Pages

Prevalence of Neuropathic Pain in Morocco: A Systematic Review and Meta-Analysis

  • Zhor Zeghari,
  • Jihane Belayachi,
  • Redouan El Ouardi and
  • Redouane Abouqal

14 May 2025

This study aims to assess the prevalence of neuropathic pain in the Moroccan population through a systematic review and meta-analysis using a generalized linear mixed model (GLMM). The PRISMA guidelines for systematic reviews and meta-analysis were f...

(This article belongs to the Special Issue Pain and Therapy: Historical Perspectives and Future Directions)
  • Review
  • Open Access
18 Citations
7,628 Views
19 Pages

Innovative Strategies in the Diagnosis and Treatment of Liver Cirrhosis and Associated Syndromes

  • Ashok Kumar Sah,
  • Mohd Afzal,
  • Rabab H. Elshaikh,
  • Anass M. Abbas and ,
  • Manar G. Shalabi,
  • Pranav Kumar Prabhakar,
  • Asaad M. A. Babker,
  • Fariza Tursunbaevna Khalimova,
  • Velilyaeva Aliya Sabrievna and
  • Ranjay Kumar Choudhary
  • + 5 authors+ 0 author

13 May 2025

Liver cirrhosis continues to be a major global health issue, contributing to high morbidity and mortality due to its progressive nature and associated complications. This review explores recent advancements in the diagnosis and treatment of liver cir...

(This article belongs to the Special Issue New Insights into Diagnosis and Therapeutic Strategies for Chronic Liver Diseases)

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