Table of Contents
Cells, Volume 9, Issue 6 (June 2020) – 243 articles
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Cover Story (view full-size image) Due to their high cell plasticity, tumor cells may switch into a different histological subtype to [...] Read more. Due to their high cell plasticity, tumor cells may switch into a different histological subtype to escape from targeted therapy. In this study, we demonstrated that long-term androgen signal depletion of prostate LNCaP cells, either by incubation in charcoal-stripped medium or by 2-hidroxyflutamide treatment, induced a neuroendocrine phenotype followed by re-differentiation towards a “stem-like” state. The prostate stem-like cells had enhanced expression of the stem cell markers CD133, ALDH1A1, and ABCB1A and the pluripotent transcription factors Nanog and Oct4. Additionally, those cells were resistant to docetaxel and 2-hidroxyflutamide. Overexpression of AMPK in stem-like cells downregulated stem markers while restoring docetaxel sensitivity, providing a new regulatory mechanism of prostate cancer plasticity through AMPK. View this paper