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Moonlighting in Mitosis: Analysis of the Mitotic Functions of Transcription and Splicing Factors

1
IBPM CNR c/o Department of Biology and Biotechnology, Sapienza University of Rome, 00185 Rome, Italy
2
Institute of Molecular and Cellular Biology, Siberian Branch of RAS, 630090 Novosibirsk, Russia
3
Department of Cell Biology, Albert Einstein College of Medicine, Bronx, New York, NY 10461, USA
4
Wellcome Centre for Cell Biology, School of Biological Sciences, University of Edinburgh, Edinburgh EH9 3BF, UK
5
Department of Biology and Biotechnology, Sapienza University of Rome, 00185 Rome, Italy
*
Authors to whom correspondence should be addressed.
These authors contributed equally.
Cells 2020, 9(6), 1554; https://doi.org/10.3390/cells9061554
Received: 9 May 2020 / Revised: 22 June 2020 / Accepted: 23 June 2020 / Published: 26 June 2020
(This article belongs to the Special Issue Frontiers in Cytoskeleton Research—From Development to Disease)
Moonlighting proteins can perform one or more additional functions besides their primary role. It has been posited that a protein can acquire a moonlighting function through a gradual evolutionary process, which is favored when the primary and secondary functions are exerted in different cellular compartments. Transcription factors (TFs) and splicing factors (SFs) control processes that occur in interphase nuclei and are strongly reduced during cell division, and are therefore in a favorable situation to evolve moonlighting mitotic functions. However, recently published moonlighting protein databases, which comprise almost 400 proteins, do not include TFs and SFs with secondary mitotic functions. We searched the literature and found several TFs and SFs with bona fide moonlighting mitotic functions, namely they localize to specific mitotic structure(s), interact with proteins enriched in the same structure(s), and are required for proper morphology and functioning of the structure(s). In addition, we describe TFs and SFs that localize to mitotic structures but cannot be classified as moonlighting proteins due to insufficient data on their biochemical interactions and mitotic roles. Nevertheless, we hypothesize that most TFs and SFs with specific mitotic localizations have either minor or redundant moonlighting functions, or are evolving towards the acquisition of these functions. View Full-Text
Keywords: transcription factors; splicing factors; multifunctional proteins; protein moonlighting; mitosis; microtubules; spindle; centrosomes; kinetochores; midbody transcription factors; splicing factors; multifunctional proteins; protein moonlighting; mitosis; microtubules; spindle; centrosomes; kinetochores; midbody
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MDPI and ACS Style

Somma, M.P.; Andreyeva, E.N.; Pavlova, G.A.; Pellacani, C.; Bucciarelli, E.; Popova, J.V.; Bonaccorsi, S.; Pindyurin, A.V.; Gatti, M. Moonlighting in Mitosis: Analysis of the Mitotic Functions of Transcription and Splicing Factors. Cells 2020, 9, 1554. https://doi.org/10.3390/cells9061554

AMA Style

Somma MP, Andreyeva EN, Pavlova GA, Pellacani C, Bucciarelli E, Popova JV, Bonaccorsi S, Pindyurin AV, Gatti M. Moonlighting in Mitosis: Analysis of the Mitotic Functions of Transcription and Splicing Factors. Cells. 2020; 9(6):1554. https://doi.org/10.3390/cells9061554

Chicago/Turabian Style

Somma, Maria P.; Andreyeva, Evgeniya N.; Pavlova, Gera A.; Pellacani, Claudia; Bucciarelli, Elisabetta; Popova, Julia V.; Bonaccorsi, Silvia; Pindyurin, Alexey V.; Gatti, Maurizio. 2020. "Moonlighting in Mitosis: Analysis of the Mitotic Functions of Transcription and Splicing Factors" Cells 9, no. 6: 1554. https://doi.org/10.3390/cells9061554

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