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Open AccessFeature PaperReview

Insight into Salivary Gland Aquaporins

Laboratory of Pathophysiological and Nutritional Biochemistry, Faculty of Medicine, Université Libre de Bruxelles, 808 Route de Lennik, Blg G/E CP 611, B-1070 Brussels, Belgium
McGill Craniofacial Tissue Engineering and Stem Cells Laboratory, Faculty of Dentistry, McGill University, Montreal, QC H3A 0C7, Canada
Oral Pathology Department, Faculty of Dentistry, Mansoura University, 35516 Mansoura, Egypt
Author to whom correspondence should be addressed.
Cells 2020, 9(6), 1547;
Received: 9 June 2020 / Revised: 23 June 2020 / Accepted: 23 June 2020 / Published: 25 June 2020
(This article belongs to the Special Issue Advances in Aquaporins)
The main role of salivary glands (SG) is the production and secretion of saliva, in which aquaporins (AQPs) play a key role by ensuring water flow. The AQPs are transmembrane channel proteins permeable to water to allow water transport across cell membranes according to osmotic gradient. This review gives an insight into SG AQPs. Indeed, it gives a summary of the expression and localization of AQPs in adult human, rat and mouse SG, as well as of their physiological role in SG function. Furthermore, the review provides a comprehensive view of the involvement of AQPs in pathological conditions affecting SG, including Sjögren’s syndrome, diabetes, agedness, head and neck cancer radiotherapy and SG cancer. These conditions are characterized by salivary hypofunction resulting in xerostomia. A specific focus is given on current and future therapeutic strategies aiming at AQPs to treat xerostomia. A deeper understanding of the AQPs involvement in molecular mechanisms of saliva secretion and diseases offered new avenues for therapeutic approaches, including drugs, gene therapy and tissue engineering. As such, AQP5 represents a potential therapeutic target in different strategies for the treatment of xerostomia. View Full-Text
Keywords: aquaporin; salivary gland; physiology; pathophysiology; regenerative medicine; xerostomia aquaporin; salivary gland; physiology; pathophysiology; regenerative medicine; xerostomia
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MDPI and ACS Style

D’Agostino, C.; Elkashty, O.A.; Chivasso, C.; Perret, J.; Tran, S.D.; Delporte, C. Insight into Salivary Gland Aquaporins. Cells 2020, 9, 1547.

AMA Style

D’Agostino C, Elkashty OA, Chivasso C, Perret J, Tran SD, Delporte C. Insight into Salivary Gland Aquaporins. Cells. 2020; 9(6):1547.

Chicago/Turabian Style

D’Agostino, Claudia; Elkashty, Osama A.; Chivasso, Clara; Perret, Jason; Tran, Simon D.; Delporte, Christine. 2020. "Insight into Salivary Gland Aquaporins" Cells 9, no. 6: 1547.

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