The NLRP3 Inflammasome as a Critical Actor in the Inflammaging Process
1
Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA
2
James J. Peters Veterans Affairs Medical Center, Bronx, New York, NY 10468, USA
*
Author to whom correspondence should be addressed.
Cells 2020, 9(6), 1552; https://doi.org/10.3390/cells9061552
Received: 19 May 2020 / Revised: 12 June 2020 / Accepted: 23 June 2020 / Published: 26 June 2020
(This article belongs to the Special Issue Roles of Inflammasomes in Aging and Age-Related Diseases)
As a consequence of the considerable increase in the human lifespan over the last century, we are experiencing the appearance and impact of new age-related diseases. The causal relationships between aging and an enhanced susceptibility of suffering from a broad spectrum of diseases need to be better understood. However, one specific shared feature seems to be of capital relevance for most of these conditions: the low-grade chronic inflammatory state inherently associated with aging, i.e., inflammaging. Here, we review the molecular and cellular mechanisms that link aging and inflammaging, focusing on the role of the innate immunity and more concretely on the nucleotide-binding oligomerization domain (NOD)-like receptor family pyrin domain containing 3 (NLRP3) inflammasome, as well as how the chronic activation of this inflammasome has a detrimental effect on different age-related disorders.
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Keywords:
inflammaging; NLRP3; innate immunity; age-related diseases
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited
MDPI and ACS Style
Sebastian-Valverde, M.; Pasinetti, G.M. The NLRP3 Inflammasome as a Critical Actor in the Inflammaging Process. Cells 2020, 9, 1552. https://doi.org/10.3390/cells9061552
AMA Style
Sebastian-Valverde M, Pasinetti GM. The NLRP3 Inflammasome as a Critical Actor in the Inflammaging Process. Cells. 2020; 9(6):1552. https://doi.org/10.3390/cells9061552
Chicago/Turabian StyleSebastian-Valverde, Maria; Pasinetti, Giulio M. 2020. "The NLRP3 Inflammasome as a Critical Actor in the Inflammaging Process" Cells 9, no. 6: 1552. https://doi.org/10.3390/cells9061552
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