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Cancers, Volume 16, Issue 1

January-1 2024 - 236 articles

Cover Story: Stereotactic body radiation therapy (SBRT) is a safe treatment option for localized prostate cancer, providing precise radiation doses to the tumor. In extreme-hypofractionated regimens, where intrafraction prostate displacement can impact treatment efficacy, real-time monitoring is employed to avoid the excessive exposure of healthy tissue or insufficient target coverage, but with a continuous investment of resources and time. Our approach focuses on reducing intrafraction motion impact by shortening delivery time while maintaining treatment quality. This involves optimal patient preparation, flattening-filter-free beams, appropriate margins, and one therapy arc. This study aims to comprehensively present data on optimizing linac-based single-arc SBRT for localized prostate cancer. View this paper
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Articles (236)

  • Article
  • Open Access
6 Citations
4,639 Views
15 Pages
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Prognostic Value of Metastatic Lymph Node Ratio and Identification of Factors Influencing the Lymph Node Yield in Patients Undergoing Curative Colon Cancer Resection

  • Paweł Mroczkowski,
  • Samuel Kim,
  • Ronny Otto,
  • Hans Lippert,
  • Radosław Zajdel,
  • Karolina Zajdel and
  • Anna Merecz-Sadowska
Cancers2024, 16(1), 218;https://doi.org/10.3390/cancers16010218

2 January 2024

Due to the impact of nodal metastasis on colon cancer prognosis, adequate regional lymph node resection and accurate pathological evaluation are required. The ratio of metastatic to examined nodes may bring an additional prognostic value to the actua...

Full Article
  • Systematic Review
  • Open Access
12 Citations
3,446 Views
21 Pages
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Diagnostic Performance of [18F]F-FDG Positron Emission Tomography (PET) in Non-Ophthalmic Malignant Melanoma: A Systematic Review and Meta-Analysis of More Than 10,000 Melanoma Patients

  • Nazanin Zamani-Siahkali,
  • Seyed Ali Mirshahvalad,
  • Christian Pirich and
  • Mohsen Beheshti
Cancers2024, 16(1), 215;https://doi.org/10.3390/cancers16010215

2 January 2024

We described the diagnostic performance of [18F]F-FDG-PET in malignant melanoma by conducting a comprehensive systematic review and meta-analysis of the existing literature. The study was designed following PRISMA-DTA. Original articles with adequate...

Full Article
  • Article
  • Open Access
2,582 Views
11 Pages
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Evaluation of Three Imaging Methods to Quantify Key Events in Pelvic Bone Metastasis

  • Haejun Lee,
  • Tae Ran Ahn,
  • Kyung Hoon Hwang and
  • Sheen-Woo Lee
Cancers2024, 16(1), 214;https://doi.org/10.3390/cancers16010214

2 January 2024

Background: The purpose of this study is to compare turbo spin echo diffusion-weighted images in radial trajectory (BLADE DWI) with multi-shot echoplanar imaging (RESOLVE DWI) for imaging the metastatic lesion in the pelvic bone to find a correlation...

Full Article
  • Article
  • Open Access
7 Citations
4,203 Views
15 Pages
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Symptomatic Benign Prostatic Hyperplasia with Suppressed Epigenetic Regulator HOXB13 Shows a Lower Incidence of Prostate Cancer Development

  • Nimrod S. Barashi,
  • Tiandao Li,
  • Duminduni H. Angappulige,
  • Bo Zhang,
  • Harry O’Gorman,
  • Charles U. Nottingham,
  • Anup S. Shetty,
  • Joseph E. Ippolito,
  • Gerald L. Andriole and
  • Nupam P. Mahajan
  • + 2 authors
Cancers2024, 16(1), 213;https://doi.org/10.3390/cancers16010213

2 January 2024

Our objective was to identify variations in gene expression that could help elucidate the pathways for the development of prostate cancer (PCa) in men with Benign Prostatic Hyperplasia (BPH). We included 98 men with BPH, a positive prostate MRI (Pros...

Full Article
  • Article
  • Open Access
1 Citations
3,009 Views
14 Pages
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Imaging Delay Following Liver-Directed Therapy Increases Progression Risk in Early- to Intermediate-Stage Hepatocellular Carcinoma

  • Jordin Stanneart,
  • Kelley G. Nunez,
  • Tyler Sandow,
  • Juan Gimenez,
  • Daniel Fort,
  • Mina Hibino,
  • Ari J. Cohen and
  • Paul T. Thevenot
Cancers2024, 16(1), 212;https://doi.org/10.3390/cancers16010212

2 January 2024

Hepatocellular carcinoma (HCC) remains one of the leading causes of cancer-related deaths in the world. Patients with early-stage HCC are treated with liver-directed therapies to bridge or downstage for liver transplantation (LT). In this study, the...

Full Article
  • Article
  • Open Access
2 Citations
2,665 Views
12 Pages
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Diffuse C-Cells Hyperplasia Is the Source of False Positive Calcitonin Measurement in FNA Washout Fluids of Thyroid Nodules: A Rational Clinical Approach to Avoiding Unnecessary Surgery

  • Chiara Mura,
  • Rossella Rodia,
  • Silvia Corrias,
  • Antonello Cappai,
  • Maria Letizia Lai,
  • Gian Luigi Canu,
  • Fabio Medas,
  • Pietro Giorgio Calò,
  • Stefano Mariotti and
  • Francesco Boi
Cancers2024, 16(1), 210;https://doi.org/10.3390/cancers16010210

2 January 2024

Purpose: The FNA-CT is useful for the diagnosis of MTC. The aim of this study was to evaluate the performance of FNA-CT in TNs coexisting with CCH. Methods: This study retrospectively reviewed the records of 11 patients with TNs submitted to thyroide...

Full Article
  • Article
  • Open Access
6 Citations
2,707 Views
11 Pages
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Evaluation of the Histone Deacetylase 2 (HDAC-2) Expression in Human Breast Cancer

  • Christos Damaskos,
  • Iason Psilopatis,
  • Anna Garmpi,
  • Dimitrios Dimitroulis,
  • Konstantinos Nikolettos,
  • Kleio Vrettou,
  • Panagiotis Sarantis,
  • Evangelos Koustas,
  • Gregory Kouraklis and
  • Efstathios A. Antoniou
  • + 7 authors
Cancers2024, 16(1), 209;https://doi.org/10.3390/cancers16010209

1 January 2024

Background/Aim: Triple negative breast cancer belongs to the most aggressive breast cancer forms. Histone deacetylases (HDACs) constitute a class of enzymes that exhibit a significant role in breast cancer genesis and progression. In this study, we a...

Full Article
  • Article
  • Open Access
1 Citations
2,025 Views
9 Pages
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The Value of Surveillance Imaging of Oral Squamous Cell Carcinoma

  • Oliver Bissinger,
  • Anne Von den Hoff,
  • Elisabeth Maier,
  • Katharina Theresa Obermeier,
  • Herbert Stimmer,
  • Andreas Kolk,
  • Klaus-Dietrich Wolff and
  • Carolin Götz
Cancers2024, 16(1), 207;https://doi.org/10.3390/cancers16010207

1 January 2024

The evaluation of surveillance imaging of OSCC patients is a difficult task physicians have to face daily. Multiple patients experience a recurrence of this disease, which underlines the importance of regular patient monitoring programs. Our study an...

Full Article
  • Article
  • Open Access
4 Citations
2,647 Views
12 Pages
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Artificial Intelligence and Panendoscopy—Automatic Detection of Clinically Relevant Lesions in Multibrand Device-Assisted Enteroscopy

  • Francisco Mendes,
  • Miguel Mascarenhas,
  • Tiago Ribeiro,
  • João Afonso,
  • Pedro Cardoso,
  • Miguel Martins,
  • Hélder Cardoso,
  • Patrícia Andrade,
  • João P. S. Ferreira and
  • Miguel Mascarenhas Saraiva
  • + 1 author
Cancers2024, 16(1), 208;https://doi.org/10.3390/cancers16010208

1 January 2024

Device-assisted enteroscopy (DAE) is capable of evaluating the entire gastrointestinal tract, identifying multiple lesions. Nevertheless, DAE’s diagnostic yield is suboptimal. Convolutional neural networks (CNN) are multi-layer architecture art...

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