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Cancers, Volume 15, Issue 24

December-2 2023 - 193 articles

Cover Story: This biophysical study aimed to determine fitting parameters for the Lyman–Kutcher–Burman (LKB) dose–response model for normal tissue complication probability (NTCP) calculations of radiogenic side effects and to investigate the impact of modern reduced radiation doses on the probability of their occurrence in supradiaphragmatic non-Hodgkin lymphoma (NHL) irradiation. Acute side effects, which already occur at low organ doses, can only be described to a limited extent by the models given in the literature. Considering a robust normal tissue toxicity model, able to predict an acute response in normal tissue adequately, dose prescriptions and treatment plans can be optimized to increase the treatment quality and, thus, the outcome for the patient. View this paper
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Articles (193)

  • Systematic Review
  • Open Access
8 Citations
3,661 Views
15 Pages

Effects of Exercise Training on Patient-Specific Outcomes in Pancreatic Cancer Patients: A Scoping Review

  • Kim Rosebrock,
  • Marianne Sinn,
  • Faik G. Uzunoglu,
  • Carsten Bokemeyer,
  • Wiebke Jensen and
  • Jannike Salchow

18 December 2023

Background: International guidelines have already highlighted the beneficial effects of exercise in common cancer entities. However, specific recommendations for pancreatic cancer are still missing. This scoping review aimed to evaluate the impact of...

  • Article
  • Open Access
1 Citations
1,829 Views
17 Pages

Tasks and Experiences of the Prospective, Longitudinal, Multicenter MoMar (Molecular Markers) Study for the Early Detection of Mesothelioma in Individuals Formerly Exposed to Asbestos Using Liquid Biopsies

  • Daniel Gilbert Weber,
  • Swaantje Casjens,
  • Katharina Wichert,
  • Martin Lehnert,
  • Dirk Taeger,
  • Hans-Peter Rihs,
  • Thomas Brüning,
  • Georg Johnen and
  • the MoMar Study Group

18 December 2023

Mesothelioma is an aggressive cancer, strongly associated with prior exposure to asbestos. Commonly, tumors are detected at late stages of the disease. Detection at early stages might be meaningful, because therapies might be more effective when the...

  • Article
  • Open Access
5 Citations
9,640 Views
12 Pages

Disparities in Cancer Incidence across Income Levels in South Korea

  • Su-Min Jeong,
  • Kyu-Won Jung,
  • Juwon Park,
  • Nayeon Kim,
  • Dong Wook Shin and
  • Mina Suh

18 December 2023

Background: Recent nationwide studies of disparities in cancer incidence by income are scarce in Korea. This study investigated such disparities in cancer incidence and the stage at cancer diagnosis across income groups in Korea. Methods: This study...

  • Article
  • Open Access
4 Citations
3,048 Views
12 Pages

Feasibility Study Utilizing NanoString’s Digital Spatial Profiling (DSP) Technology for Characterizing the Immune Microenvironment in Barrett’s Esophagus Formalin-Fixed Paraffin-Embedded Tissues

  • Qurat-ul-Ain,
  • Nicola F. Frei,
  • Amir M. Khoshiwal,
  • Pim Stougie,
  • Robert Odze,
  • Sophie Camilleri-Broet,
  • Lorenzo Ferri,
  • Lucas C. Duits,
  • Jacques Bergman and
  • Matthew D. Stachler

18 December 2023

Characterization of the Barrett’s esophagus (BE) microenvironment in patients with a known progression status, to determine how it may influence BE progression to esophageal adenocarcinoma (EAC), has been understudied, hindering both the biolog...

  • Article
  • Open Access
1 Citations
1,658 Views
10 Pages

18 December 2023

Clear cell renal cell carcinoma (CCRCC) is an aggressive form of cancer and a paradigmatic example of intratumor heterogeneity (ITH). The hawk-dove game is a mathematical tool designed to analyze competition in biological systems. Using this game, th...

  • Article
  • Open Access
2 Citations
1,823 Views
10 Pages

Oncologic Outcome of Robotic-Assisted and Laparoscopic Sentinel Node Biopsy in Endometrial Cancer

  • Atanas Ignatov,
  • József Mészáros,
  • Stylianos Ivros,
  • Paolo Gennari and
  • Tanja Ignatov

18 December 2023

Background: Recently, sentinel lymph node biopsy (SLNB) has been introduced in the surgical staging of endometrial cancer as an alternative to systematic lymph node dissection (LND). However, the survival impact of SLNB is not yet well characterised....

  • Article
  • Open Access
3 Citations
2,507 Views
19 Pages

Development of a Genetically Engineered Mouse Model Recapitulating LKB1 and PTEN Deficiency in Gastric Cancer Pathogenesis

  • Kuan-Te Fang,
  • Hsin Hung,
  • Nga Yin Sadonna Lau,
  • Jou-Hsi Chi,
  • Deng-Chyang Wu and
  • Kuang-Hung Cheng

18 December 2023

The LKB1 and PTEN genes are critical in gastric cancer (G.C.) development. LKB1, a robust tumor suppressor gene, encodes a serine/threonine kinase that directly triggers the activation of AMPK—an integral cellular metabolic kinase. The role of...

  • Article
  • Open Access
11 Citations
2,482 Views
21 Pages

Determinants Affecting the Clinical Implementation of a Molecularly Informed Molecular Tumor Board Recommendation: Experience from a Tertiary Cancer Center

  • Lars Tögel,
  • Christoph Schubart,
  • Sebastian Lettmaier,
  • Clemens Neufert,
  • Juliane Hoyer,
  • Kerstin Wolff,
  • Evgeny A Moskalev,
  • Robert Stöhr,
  • Abbas Agaimy and
  • André Reis
  • + 9 authors

18 December 2023

Molecular Tumor Boards (MTBs) converge state-of-the-art next-generation sequencing (NGS) methods with the expertise of an interdisciplinary team consisting of clinicians, pathologists, human geneticists, and molecular biologists to provide molecularl...

  • Systematic Review
  • Open Access
3 Citations
2,554 Views
13 Pages

Radiomics for Differentiation of Pediatric Posterior Fossa Tumors: A Meta-Analysis and Systematic Review of the Literature

  • Alexandru Garaba,
  • Francesco Ponzio,
  • Eleonora Agata Grasso,
  • Waleed Brinjikji,
  • Marco Maria Fontanella and
  • Lucio De Maria

18 December 2023

Purpose: To better define the overall performance of the current radiomics-based models for the discrimination of pediatric posterior fossa tumors. Methods: A comprehensive literature search of the databases PubMed, Ovid MEDLINE, Ovid EMBASE, Web of...

  • Article
  • Open Access
5 Citations
2,305 Views
11 Pages

18 December 2023

Background: Head and neck cancer is highly prevalent in Taiwan. Its treatment mainly relies on clinical staging, usually diagnosed from images. A major part of the diagnosis is whether lymph nodes are involved in the tumor. We present an algorithm fo...

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Cancers - ISSN 2072-6694