Table of Contents
Toxins, Volume 10, Issue 10 (October 2018)
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Cover Story (view full-size image) Antivenom cross-reactivity has been investigated for decades to determine which antivenoms can be [...] Read more. Antivenom cross-reactivity has been investigated for decades to determine which antivenoms can be used to treat snakebite envenomings from different snake species. Besides the traditional methods for cross-reactivity investigations, such as enzymatic assays and in vivo neutralization studies, new methods, including antivenomics and high-density peptide microarray (HDPM) technology, have recently emerged. We provide an overview of both the classical and new methods used to explore antivenom cross-reactivity, the advantages and disadvantages of these methods, and examples of studies using the methods. A special focus is given to antivenomics and HDPM technology as these high-throughput methods may enable more detailed assessments of antivenom cross-reactivity. View this paper.