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Toxins 2018, 10(10), 419;

Effects of a Fusarium Toxin-Contaminated Maize Treated with Sodium Sulfite on Male Piglets in the Presence of an LPS-Induced Acute Inflammation

Institute of Animal Nutrition, Friedrich-Loeffler-Institut (FLI), Federal Research Institute for Animal Health, Bundesallee 37, 38116 Braunschweig, Germany
BIOMIN Holding GmbH, BIOMIN Research Center, Technopark 1, 3430 Tulln, Austria
Author to whom correspondence should be addressed.
Received: 15 August 2018 / Revised: 4 October 2018 / Accepted: 12 October 2018 / Published: 18 October 2018
(This article belongs to the Collection Fusarium Toxins – Relevance for Human and Animal Health)
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We investigated the effects of feeding sodium sulfite (SoS) treated uncontaminated and Fusarium contaminated maize in a porcine lipopolysaccharide (LPS) challenge model. Eighty piglets (7.59 ± 0.92 kg body weight [BW]) were equally assigned to one of four experimental diets containing 10% maize, either uncontaminated and untreated (CON−, 0.09 mg deoxynivalenol [DON]/kg diet) or uncontaminated and SoS-treated (CON+, wet-preserved with 5 g SoS/kg maize; 0.05 mg DON/kg diet), or prepared with 10% of a Fusarium contaminated maize containing mainly deoxynivalenol (DON), either contaminated and untreated (FUS−, 5.36 mg DON/kg diet), or contaminated and SoS-treated (FUS+, wet-preserved with 5 g SoS/kg maize; 0.83 mg DON/kg diet). At day 42 of experiment, ten pigs of each group were injected intraperitoneally with either 7.5 µg LPS/kg BW or placebo (0.9% NaCl). At 120 min after injection, blood samples were collected to analyse TNF-α, hematological profile, clinical biochemistry as well as the redox status. A significant increase in body temperature and cytokine TNF-α concentration was observed in the LPS-injected piglets. Results for hematology, clinical chemistry and redox status indicate no effects of SoS treatment, with exception of neutrophil counts being significantly more pronounced after feeding the SoS treated FUS maize. In conclusion, SoS treatment of maize did not modulate the LPS-induced acute inflammation. View Full-Text
Keywords: deoxynivalenol; sodium sulfite; detoxification; piglets; lipopolysaccharide deoxynivalenol; sodium sulfite; detoxification; piglets; lipopolysaccharide

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Tran, A.-T.; Kluess, J.; Berk, A.; Paulick, M.; Frahm, J.; Schatzmayr, D.; Kersten, S.; Dänicke, S. Effects of a Fusarium Toxin-Contaminated Maize Treated with Sodium Sulfite on Male Piglets in the Presence of an LPS-Induced Acute Inflammation. Toxins 2018, 10, 419.

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