Table of Contents
Toxins, Volume 10, Issue 9 (September 2018)
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Cover Story (view full-size image) Using systemic donepezil application, we studied if the reduction of apomorphine-induced rotations [...] Read more. Using systemic donepezil application, we studied if the reduction of apomorphine-induced rotations caused by intrastriatal BoNT-A in hemiparkinsonian rats is dependent on acetylcholine (ACh). Schemes of the indirect pathway of the basal ganglia circuitry with main neurons and connections of the striatum are depicted under normal and experimental conditions. An exemplary presynapse of a cholinergic interneuron contains ACh (dots). Rectangles symbolize SNARE complexes which convey the fusion of ACh-containing vesicles with the presynaptic membrane. Scissors represent acetylcholinesterase (AChE) which cleaves ACh, and the medium spiny neuron (colored blue) inhibits the globus pallidus externus (Gpe) by GABA. View this paper.