Molbank, Volume 2004, Issue 1

In our previous work we have demonstrated the utility of the 2,2,2-trichloro-1,1-dimethylethyl (b, b, b-trichloro-tert-butyl, Tcb) group for the protection of carboxylic acids [1].[...]

In our previous work we have demonstrated the utility of the 2,2,2-trichloro-1,1-dimethylethyl (β,β,β-trichloro-tert-butyl, Tcb) group for the protection of carboxylic acids [1].[...]

In our previous work we have demonstrated the utility of the 2,2,2-trichloro-1,1-dimethylethyl (b,b,b-trichloro-tert-butyl, Tcb) group for the protection of carboxylic acids [1].[...]

{6-[(4-Methoxybenzoyl)amino]-9H-purin-9-yl}acetic acid 2 is one of the substances used in the synthesis of peptide nucleic acid (PNA) adenine monomer and oligomers as well.[...]

The plant, Urena lobata L. (Malvaceae) is reputed for its use in indigenous system of medicine.[...]

To a solution of 3,8-dihydroxy-2,9-dimethyl deca-3,7-diene-5,6-dione 2 [1] (270 mg, 1.2 mmol) in absolute ethanol (20 mL) was added the orthophenylenediamine 1 (129 mg, 1.2 mmol) and the mixture was refluxed for one hour [2].[...]

To a solution of 3,8-dihydroxy-2,9-dimethyl deca-3,7-diene-5,6-dione 2 [1] (452 g, 2 mmol) in absolute ethanol (15 mL) was added the 4-methylorthophenylenediamine 1 (244 mg, 2 mmol) and the mixture was refluxed for 90 min [2].[...]

To a solution of 3,8-dihydroxy-2,9-dimethyl deca-3,7-diene-5,6-dione 2 [1] (1.278 g, 5.6 mmol) in absolute ethanol (20 mL) was added the 4-nitro-orthophenylenediamine 1 (0.865 g, 5.6 mmol) and the mixture was refluxed for 2 hours [2].[...]

7,10-Diazafluoranthene has been reported to be strongly mutagenic in an Ames-test [1], but no details regarding neither the synthesis nor other properties have been published.[...]

A solution of bromine (0.3 mL, 5.90 mmol) in CCl₄ (2 mL) was slowly added over a stirred mixture of 3-methyl-butan-2-one (1) (505 mg, 5.90 mmol) and AcOH (0.33 mL) at room temperature.[...]

Ethyl 2-methylacetoacetate (2) (727 mg, 4.53 mmol) was added to a stirred solution of NaH (184 mg, 4.60 mmol) in dioxane (25 mL).[...]

p-Toluenesulfonic acid (35 mg, 0.20 mmol) was added to a stirred mixture of campholenic aldehyde (1) (725 mg, 3.81 mmol) and p-toluenesulfonamide (1.22 g, 6.96 mmol) in toluene (20 mL).[...]

A mixture of 2-benzyloxymethylfuran[1] (1.88 g, 10 mmol) and pentachloroacetone[2] (2.30 g, 10 mmol) was cooled in an ice bath.[...]

A solution of furfurylamine[1] (9.77 g, 100 mmol) in tert-butylmethyl ether[2] (MTBE, 50 mL) was made in a 250-mL four-necked flask, fitted with two dropping funnels and an immersion thermometer, and cooled in an ice/salt bath to -15 °C.[...]

(2Z)-3-(2-Nitrophenyl)-2-(4-methylphenyl)acrylonitrile (3) was prepared by Knoevenagel condensation of 2-nitrobenzaldehyde 1 and 4-methylphenylacetonitrile 2 in ethanol using KOH as a base [1,2].[...]

A mixture of 4,4'-diaminodiphenyl ether 1 (1.00 g, 5.00 mmol), o-vanillin 2 (1.52 g, 10.00 mmol) in methanol (40.00 mL) was stirred at room temperature for one hour to give an orange precipitate. [...]

A mixture of (3,4-diaminophenyl) phenyl methanone 1 (2.12 g, 10.00 mmol), 2-hydroxybenzaldehyde 2 (2.44 g, 20.00 mmol) and sodium sulfate (5.00 g) in dry dichloromethane (50.00 ml) was stirred at room temperature for five hours.[...]

9H-Carbazole derivatives are known to have fluorescent properties and therefore they have exploitation in analytical chemistry, especially in bioanalytical chemistry.[...]

The product 3 was prepared by the condensation of dienone 2 [1] (1g, 3.11 mmol) with o-phenylenediamine 1 (0.33g, 3.11 mmol) by refluxing an ethanol (50 mL) solution for 1 h.[...]

The product 3 was prepared by the condensation of dienone 2 [1] (1g, 3.1 mmol) with 3,4-diaminotoluene 1 (0.38 g, 3.1 mmol) by refluxing an ethanol (50 mL) solution for 1 h.[...]

(s)-2,2’-Bis[Bromomethyl]-1,1’-binaphthyl was prepared via the bromination of (s)-2,2’-dimethyl-1,1’-binaphthyl[1] by N-bromosuccinimide (NBS) in CCl₄ with benzoyl peroxide as initiator (yield: 45.0%).[...]

A mixture of 4,4'-diaminodiphenyl ether 1 (2.00 g, 10.00 mmol), indole-3-carboxaldehyde 2 (2.90 g, 20.00 mmol) in absolute ethanol (50.00 mL) was stirred at room temperature for 8 hours.[...]

1,3-Diethyl-5-(2-methoxybenzylidene)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione 3 was prepared by Knoevenagel condensation of 2-methoxybenzaldehyde 1 and N,N-diethylthiobarbituric acid 2 in ethanol using piperidine as a base [1,2].[...]

1,3-Diethyl-5-(4-methoxybenzylidene)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione 3 was prepared by Knoevenagel condensation of 4-methoxybenzaldehyde 1 and N,N-diethylthiobarbituric acid 2 in ethanol using piperidine as a base [1,2].[...]

5-(3,4-Dimethoxybenzylidene)-1,3-diethyl-2-thioxodihydropyrimidine-4,6(1H,5H)-dione 3 was prepared by Knoevenagel condensation of 3,4di-methoxybenzaldehyde 1 and N,N-diethylthiobarbituric acid 2 in ethanol using piperidine as a base [1,2].[...]

A mixture of Vanillin 1 (0.5 g, 3.3 mmol) and triphenylphosphine (0.86 g, 3.3 mmol) was dissolved in CH₂Cl₂.[...]

A mixture of vanillin 1 ( 0.5g, 3.3mmol) and triphenylphosphine ( 0.86g, 3.3mmol) was dissolved in CH₂Cl₂.[...]

Schiff bases are reported to show a variety of biological activities such as antibacterial [1,2,3], antifungal [4,5], anticancer [6,7] and herbicidal [8] activities.[...]

To a solution of 1¹ (1g, 1.68mmol) in 20ml of acetone, was added (0.50g, 0.85mmol) of chromic anhydride².[...]

5-Nitro-1,2,3,4-tetrahydropyrimidine derivatives [1, 2] are known to possess important biological properties.[...]

A mixture of (3,5-dimethyl-1H-pyrazol-1-yl)methanol 1 [1] (1.84 g, 14.6 mmol) and 4-aminobenzoic acid 2 (1g, 7.3 mmol) in acetonitrile (50 mL) was stirred in a closed vessel at room temperature for 6 days [2,3,4].[...]

A mixture of (3,5-dimethyl-1H-pyrazol-1-yl)methanol 1 [1] (1.86 g, 14.8 mmol) and 4-amino-acetophenone 2 (1g, 7.4 mmol) in acetonitrile (50 mL) was stirred in a closed vessel at room temperature for 6 days [2,3,4].[...]

To a mixture of 3-chloromethyl-1,5-dimethylpyrazole 1 [1] (6g, 41mmol) and sodium carbonate (17g, 160mmol) in 150 mL of acetonitrile was added slowly 2-aminoethanol 2 (1.25g, 20.5 mmol).[...]

Diazo compounds have interesting biological activities [1,2,3,4].[...]

Continuing our study on the application of 1,2,4-triazines in organic synthesis [1] we prepared the title compounds as valuable intermediates for metalation reactions leading to functionalized 5,5’-bi-1,2,4-triazines [2].[...]

Pyrazines are found in such heated foods as bread, different meats, baked potatoes and coffee [1], which are formed from serine and thereonine [2].[...]

Benzophenone derivatives are reported to show biological activities such as cytotoxic activities against human oral squarnous carcinoma cells (HSC-2) and normal human gingival fibroblasts (HGF) [1], antibiotic activities against methicillin-resistant...

2,9-dimethyl-1,10-phenanthroline-5,6-dione was synthesized by the procedure for the preparation of 1,10-phenanthroline-5,6-dione [1].[...]

Schiff bases are used as substrates in the preparation of a large of bioactive and industrial compounds via ring closure, cycloaddition, replacement reactions, etc [1].[...]

Schiff bases are a class of important compounds in medicinal and pharmaceutical field.[...]