Artificial Intelligence in Molecular Medicine and Human Diseases

Dear Colleagues,

Artificial intelligence is rapidly transforming biomedical and molecular research by enabling the integration and interpretation of complex, heterogeneous, and high-dimensional biological and clinical data. In the context of human diseases, AI-based approaches are increasingly being used to investigate disease mechanisms at the molecular level, identify diagnostic and prognostic biomarkers, model disease progression, and support precision medicine strategies. 

This Special Issue aims to highlight recent advances in the application of artificial intelligence, machine learning, and deep learning to molecular research on human diseases. We welcome original research articles and comprehensive reviews focused on innovative computational approaches for the analysis of molecular and biomedical data, including genomics, transcriptomics, proteomics, metabolomics, epigenomics, single-cell data, spatial omics, molecular imaging, biomarker discovery, pathway analysis, molecular network modeling, and multi-omics integration.

Particular attention will be given to studies that use AI to uncover molecular signatures, disease-associated pathways, gene–protein interactions, immune and inflammatory mechanisms, molecular subtypes, therapeutic targets, and predictors of treatment response. Contributions addressing complex human diseases, including cancer, metabolic disorders, autoimmune diseases, neurodegenerative conditions, cardiovascular diseases, infectious diseases, and multisystem inflammatory disorders, are especially encouraged when they provide mechanistic, molecular, or translational insight.

By bringing together interdisciplinary research at the interface of artificial intelligence, molecular medicine, systems biology, and clinical science, this Special Issue seeks to promote robust, interpretable, and biologically meaningful AI-driven approaches. The ultimate goal is to advance our understanding of human diseases at the molecular level and to accelerate the development of improved diagnostic, prognostic, and therapeutic strategies for precision medicine.

Dr. Jorge Mateo
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the Special Issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

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