Molecular Mechanisms of Adipose Tissue Dysfunction

Dear Colleagues,

Adipose tissue is a dynamic endocrine organ whose molecular dysfunction contributes to obesity, insulin resistance, type 2 diabetes, cardiovascular disease, and chronic low-grade inflammation. This Special Issue, entitled “Molecular Mechanisms of Adipose Tissue Dysfunction”, will provide a platform for studies elucidating the cellular, genetic, and biochemical pathways that impair adipose tissue homeostasis. We welcome contributions examining alterations in adipogenesis and adipocyte differentiation, mitochondrial dysfunction, lipid storage and mobilization, extracellular matrix remodeling, fibrosis, and dysregulated adipokine release. Particular attention will be paid to the interplay between adipocytes and immune cells, as well as communication mediated by extracellular vesicles, microRNAs, and other secreted factors. We also encourage submissions focused on depot-specific adipose biology, ectopic fat accumulation, and adipose tissue plasticity, including mechanisms of browning and beigeing. Studies employing multi-omics, single-cell and spatial approaches, advanced cellular systems, and in vivo models are particularly welcome. Contributions highlighting the role and therapeutic potential of adipose-derived stem cells in maintaining, restoring, or mediating the alteration of adipose tissue function are particularly encouraged. Fundamental in vitro research using adipocyte and stromal–vascular cell models to dissect molecular pathways, regulatory networks, and signaling mechanisms underlying adipose dysfunction is also welcomed. Overall, this Special Issue will integrate mechanistic and translational perspectives to advance understanding of adipose tissue dysfunction and support the development of strategies for improving metabolic health.

Dr. Stefano Quarta
Guest Editor

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