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Psoriasis: Molecular Pathologies, Lipid Disturbances, Diagnosis and Therapeutic Strategies
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Psoriasis: Molecular Pathologies, Lipid Disturbances, Diagnosis and Therapeutic Strategies

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: 20 January 2026 | Viewed by 606

Special Issue Editor

Dr. Hanna Mysliwiec

E-Mail Website
Guest Editor
Department of Dermatology and Venereology, Medical University of Bialystok, PL-15540 Bialystok, Poland
Interests: dermatology; skin diseases; inflammation; psoriasis; aesthetic medicine
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The treatment of psoriasis has come a long way, from the use of simple ointments like anthralin to the advanced biologic therapies that we rely on today. These improvements have greatly helped patients, but there is still so much we do not fully understand about psoriasis. The causes of the disease and how it is connected to other health problems remain areas that need more research.

Among the most intriguing connections is the role of lipid disturbances. These disruptions not only underscore the complex interplay between psoriasis and metabolic disorders but also offer valuable insights into the broader systemic effects of the disease. Alongside lipid disturbances, molecular mechanisms, including genetic, epigenetic, and inflammatory pathways, play a crucial role in shaping the clinical course of psoriasis and its associated conditions.

This Special Issue, "Psoriasis: Molecular Pathologies, Lipid Disturbances, Diagnosis and Therapeutic Strategies", aims to explore these important topics. We want to dive deeper into the molecular aspects of psoriasis, its link with lipid problems, and new ways to diagnose and treat the disease.

We invite you to contribute your research, reviews, or case studies to this Special Issue. Together, we can uncover new knowledge about psoriasis and help improve treatments and care for patients.

Dr. Hanna Mysliwiec
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • psoriasis
  • pathogenesis
  • lipid metabolism disturbances
  • metabolic syndrome
  • systemic comorbidities
  • epigenetics
  • therapeutic strategies
  • biologic treatment

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Published Papers (2 papers)

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Research

22 pages, 3942 KiB  
Article
The Therapeutic Potential of Galium verum for Psoriasis: A Combined Phytochemical, In Silico, and Experimental Approach
by Branislava Daskalovic, Vladimir Jakovljevic, Sergej Bolevic, Marijana Andjic, Jovana Bradic, Aleksandar Kocovic, Milos Nikolic, Nikola Nedeljkovic, Jovan Milosavljevic, Jovan Baljak, Milos Krivokapic, Svetlana Trifunovic and Jasmina Sretenovic
Int. J. Mol. Sci. 2025, 26(15), 7290; https://doi.org/10.3390/ijms26157290 (registering DOI) - 28 Jul 2025
Abstract
Psoriasis is a chronic inflammatory skin disorder involving oxidative stress and immune dysregulation. Given the limitations and adverse effects of conventional therapies, interest in natural treatments with anti-oxidant and immunomodulatory properties is increasing. This study aimed to comprehensively evaluate the therapeutic potential of [...] Read more.
Psoriasis is a chronic inflammatory skin disorder involving oxidative stress and immune dysregulation. Given the limitations and adverse effects of conventional therapies, interest in natural treatments with anti-oxidant and immunomodulatory properties is increasing. This study aimed to comprehensively evaluate the therapeutic potential of Galium verum extract in an imiquimod-induced rat model of psoriasis. The extract was chemically characterized by HPLC and evaluated for anti-oxidant activity using DPPH, ABTS, and FRAP assays. Molecular docking studies targeted psoriasis-related proteins (IL-17, IL-22, IL-23, JAK2, MAPK2, NF-κB, STAT3), revealing strong binding affinities for rutin and quercetin, the extract’s dominant bioactives. In vivo, 18 Wistar albino male rats were divided into control (CTRL), psoriasis (PSORI), and psoriasis treated with Galium verum (PSORI + GV) groups. A seven-day topical application of 5% imiquimod cream was used for the induction of psoriasis. The PSORI + GV group received 250 mg/kg Galium verum extract orally for 7 days. Morphometric and redox analyses were performed. Histological and morphometric analyses showed reduced epidermal thickness, inflammation, and collagen content. Redox analysis revealed lowered oxidative stress biomarkers and enhanced anti-oxidant defenses. These findings suggest that Galium verum extract exerts anti-psoriatic effects through antioxidative and immunomodulatory mechanisms, supporting its potential as a natural adjunct therapy for psoriasis. Full article
(This article belongs to the Special Issue Psoriasis: Molecular Pathologies, Lipid Disturbances, Diagnosis and Therapeutic Strategies)
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14 pages, 1217 KiB  
Article
Serum IL-18/IL-13 Ratio Predicts Super Response to Secukinumab in Patients with Psoriasis
by Dominika Ziolkowska-Banasik, Maciej Pastuszczak, Kamila Zawadzinska-Halat, Ewa Hadas and Andrzej Bozek
Int. J. Mol. Sci. 2025, 26(13), 6432; https://doi.org/10.3390/ijms26136432 - 3 Jul 2025
Viewed by 382
Abstract
Identifying immunologic predictors of clinical responses remains an unmet need in the era of biologic therapy for psoriasis. Super responders (SRs), defined as patients achieving complete skin clearance within weeks of treatment initiation, represent an emerging clinical endotype; however, their immunological profiles remain [...] Read more.
Identifying immunologic predictors of clinical responses remains an unmet need in the era of biologic therapy for psoriasis. Super responders (SRs), defined as patients achieving complete skin clearance within weeks of treatment initiation, represent an emerging clinical endotype; however, their immunological profiles remain insufficiently characterized. We conducted a prospective observational study to characterize serum cytokine profiles associated with SR status in biologic-naïve patients with moderate-to-severe plaque psoriasis treated with secukinumab, an IL-17A inhibitor. Twenty-eight patients were enrolled and stratified at week 12 into SR (PASI = 0; n = 9) and non-super responder (NSR; PASI > 0; n = 19) groups. Serum concentrations of 19 cytokines were analyzed at baseline and after 12 weeks of treatment. SRs displayed a distinct immunological signature characterized by significantly higher IL-13 and lower IL-18 baseline levels compared to NSRs (p = 0.002 and p = 0.007, respectively), alongside reduced baseline monocyte counts. L1-regularized logistic regression confirmed IL-13 and IL-18 as strong independent predictors of SR status (AUC = 0.91). Moreover, the IL-18/IL-13 ratio emerged as a highly discriminative biomarker (p = 0.00001, AUC = 0.86). Notably, SRs exhibited a more pronounced decline in IL-18 and IL-23 during treatment. Our findings provide novel insights into the immunopathogenesis of super response and suggest that an immunological milieu favoring Th2 polarization may promote superior outcomes with IL-17A blockade. Incorporating IL-13, IL-18, and their ratio into clinical algorithms may facilitate precision-guided biologic therapy in psoriasis. Full article
(This article belongs to the Special Issue Psoriasis: Molecular Pathologies, Lipid Disturbances, Diagnosis and Therapeutic Strategies)
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