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Psoriasis: Molecular Pathologies, Lipid Disturbances, Diagnosis and Therapeutic Strategies

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: closed (30 June 2025) | Viewed by 212

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Guest Editor
Department of Dermatology and Venereology, Medical University of Bialystok, PL-15540 Bialystok, Poland
Interests: dermatology; skin diseases; inflammation; psoriasis; aesthetic medicine
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Special Issue Information

Dear Colleagues,

The treatment of psoriasis has come a long way, from the use of simple ointments like anthralin to the advanced biologic therapies that we rely on today. These improvements have greatly helped patients, but there is still so much we do not fully understand about psoriasis. The causes of the disease and how it is connected to other health problems remain areas that need more research.

Among the most intriguing connections is the role of lipid disturbances. These disruptions not only underscore the complex interplay between psoriasis and metabolic disorders but also offer valuable insights into the broader systemic effects of the disease. Alongside lipid disturbances, molecular mechanisms, including genetic, epigenetic, and inflammatory pathways, play a crucial role in shaping the clinical course of psoriasis and its associated conditions.

This Special Issue, "Psoriasis: Molecular Pathologies, Lipid Disturbances, Diagnosis and Therapeutic Strategies", aims to explore these important topics. We want to dive deeper into the molecular aspects of psoriasis, its link with lipid problems, and new ways to diagnose and treat the disease.

We invite you to contribute your research, reviews, or case studies to this Special Issue. Together, we can uncover new knowledge about psoriasis and help improve treatments and care for patients.

Dr. Hanna Mysliwiec
Guest Editor

Manuscript Submission Information

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Keywords

  • psoriasis
  • pathogenesis
  • lipid metabolism disturbances
  • metabolic syndrome
  • systemic comorbidities
  • epigenetics
  • therapeutic strategies
  • biologic treatment

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Published Papers (1 paper)

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Research

14 pages, 1217 KiB  
Article
Serum IL-18/IL-13 Ratio Predicts Super Response to Secukinumab in Patients with Psoriasis
by Dominika Ziolkowska-Banasik, Maciej Pastuszczak, Kamila Zawadzinska-Halat, Ewa Hadas and Andrzej Bozek
Int. J. Mol. Sci. 2025, 26(13), 6432; https://doi.org/10.3390/ijms26136432 - 3 Jul 2025
Viewed by 12
Abstract
Identifying immunologic predictors of clinical responses remains an unmet need in the era of biologic therapy for psoriasis. Super responders (SRs), defined as patients achieving complete skin clearance within weeks of treatment initiation, represent an emerging clinical endotype; however, their immunological profiles remain [...] Read more.
Identifying immunologic predictors of clinical responses remains an unmet need in the era of biologic therapy for psoriasis. Super responders (SRs), defined as patients achieving complete skin clearance within weeks of treatment initiation, represent an emerging clinical endotype; however, their immunological profiles remain insufficiently characterized. We conducted a prospective observational study to characterize serum cytokine profiles associated with SR status in biologic-naïve patients with moderate-to-severe plaque psoriasis treated with secukinumab, an IL-17A inhibitor. Twenty-eight patients were enrolled and stratified at week 12 into SR (PASI = 0; n = 9) and non-super responder (NSR; PASI > 0; n = 19) groups. Serum concentrations of 19 cytokines were analyzed at baseline and after 12 weeks of treatment. SRs displayed a distinct immunological signature characterized by significantly higher IL-13 and lower IL-18 baseline levels compared to NSRs (p = 0.002 and p = 0.007, respectively), alongside reduced baseline monocyte counts. L1-regularized logistic regression confirmed IL-13 and IL-18 as strong independent predictors of SR status (AUC = 0.91). Moreover, the IL-18/IL-13 ratio emerged as a highly discriminative biomarker (p = 0.00001, AUC = 0.86). Notably, SRs exhibited a more pronounced decline in IL-18 and IL-23 during treatment. Our findings provide novel insights into the immunopathogenesis of super response and suggest that an immunological milieu favoring Th2 polarization may promote superior outcomes with IL-17A blockade. Incorporating IL-13, IL-18, and their ratio into clinical algorithms may facilitate precision-guided biologic therapy in psoriasis. Full article
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