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Molecules, Volume 31, Issue 1

January-1 2026 - 199 articles

Cover Story: Molecules (ISSN 1420-3049, CODEN: MOLEFW) provides an advanced forum for science of chemistry and all interfacing disciplines. Our aim is to provide rigorous peer review and enable rapid publication of cutting-edge research to educate and inspire the scientific community worldwide. Scientists are encouraged to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the maximum length of the papers. Full experimental details must be provided so that the results can be reproduced. In addition, the availability of compound samples is published and considered important information, and authors are encouraged to register or deposit their chemical samples.
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Articles (199)

  • Article
  • Open Access
274 Views
16 Pages

Chemoselectively Functionalized Ketoesters by Halogenative C–C Bond Cleavage of Cyclic Diketones

  • Hideyasu China,
  • Nami Kageyama,
  • Hodaka Yatabe,
  • Mihoyo Fujitake,
  • Yusei Matsumoto,
  • Zhihan Jing and
  • Toshifumi Dohi

5 January 2026

Haloketoesters are synthetic intermediates in various cyclization reactions that facilitate the production of biologically active compounds. Nonetheless, the selective synthesis of dihaloketoesters and trihaloketoesters, which are expected to be high...

  • Article
  • Open Access
254 Views
13 Pages

A Star-PEGylation Strategy to Improve Testosterone Pharmacokinetics

  • Chae Bin Lee,
  • Lukáš Tenora,
  • Ruoning Zhang,
  • Arina Ranjit,
  • Mark C. Markowski,
  • Barbara S. Slusher and
  • Rana Rais

5 January 2026

Testosterone, an androgenic steroid hormone, regulates primary sexual characteristics and influences mood, cognition, social behavior, and sexual function. Deficiency, caused by factors such as aging and genetics, is linked to multiple disease condit...

  • Article
  • Open Access
237 Views
19 Pages

Viniferin-Rich Phytocomplex from Vitis vinifera L. Plant Cell Culture Mitigates Neuroinflammation in BV2 Microglia Cells

  • Giacomina Videtta,
  • Chiara Sasia,
  • Sofia Quadrino,
  • Oriana Bertaiola,
  • Chiara Guarnerio,
  • Elisa Bianchi,
  • Giacomo Biagiotti,
  • Barbara Richichi,
  • Stefano Cicchi and
  • Nicoletta Galeotti

5 January 2026

Activation of microglia and resulting neuroinflammation are central processes that significantly contribute to neurodegenerative disease progression. Treatments capable of attenuating neuroinflammation are therefore an urgent medical need. Vitis vini...

  • Article
  • Open Access
222 Views
22 Pages

Bioactive Phytocompound Profiling and the Evaluation of Antioxidant, Antihyperglycemic, and Antimicrobial Activities of Medicinal Plants from Serbian Traditional Medicine

  • Milica Aćimović,
  • Anja Vučetić,
  • Jelena Vulić,
  • Aleksandra Ranitović,
  • Teodora Marić,
  • Vanja Travičić and
  • Olja Šovljanski

5 January 2026

Medicinal plants represent an important source of bioactive compounds whose composition and biological activity are strongly influenced by geographical origin and extraction conditions. In this study, six medicinal plants traditionally used in south-...

  • Article
  • Open Access
222 Views
16 Pages

5 January 2026

Tetranuclear rhodium carbonyl clusters are vital catalytic precursors; yet derivatives featuring bidentate phosphines are less common, due to the propensity for cluster fragmentation during synthesis. This study reports the successful isolation of fi...

  • Article
  • Open Access
315 Views
16 Pages

5 January 2026

Corilagin is a hydrolyzable ellagitannin and naturally occurring polyphenolic compound widely distributed in medicinal plants. It is also present in longan (Dimocarpus longan), known as lumyai in Thailand, a subtropical fruit extensively cultivated a...

  • Article
  • Open Access
312 Views
19 Pages

Antioxidant, Anti-Inflammatory, and Chemical Composition Analysis of In Vitro Huperzia serrata Thallus and Wild Huperzia serrata

  • Yongchun Huang,
  • Xinyuan Li,
  • Liangfang Dai,
  • Malong Cheng,
  • Linlin Zhao,
  • Yu Shen,
  • Jiankun Xie and
  • Xiangdong Luo

5 January 2026

Huperzine A is a preferred treatment option for Alzheimer’s disease. Huperzia serrata (Thunb. ex Murray) Trev. (H. serrata) has garnered significant attention for its ability to produce Huperzine A (HupA). However, natural populations of wild H...

  • Review
  • Open Access
374 Views
24 Pages

5 January 2026

Hydrodynamic cavitation (HC) is a green and readily scalable platform for the recovery and upgrading of bioactives from agri-food and forestry byproducts. This expert-led narrative review examines HC processing of citrus and pomegranate peels, softwo...

  • Review
  • Open Access
373 Views
14 Pages

5 January 2026

Surface-Enhanced Raman Spectroscopy (SERS) is highly attractive as an analytical technique owing to its high sensitivity, distinctive molecular specificity, and speed of analysis. It offers the potential to match the sensitivity and molecular specifi...

  • Article
  • Open Access
313 Views
15 Pages

Obtaining and Studying the Properties of Composite Materials from ortho-, meta-, para-Carboxyphenylmaleimide and ABS

  • Eldar Garaev,
  • Shahana Guliyeva,
  • Aygun Alikhanova,
  • Konul Huseynguliyeva and
  • Bakhtiyar Mammadov

5 January 2026

This work presents the results of the synthesis and investigation of new antibacterial composite materials based on acrylonitrile–butadiene–styrene (ABS) copolymer and o-, m-, p-carboxyphenylmaleimides (CPhMI). The composites were obtaine...

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Molecules - ISSN 1420-3049