Table of Contents
Molecules, Volume 24, Issue 6 (March-2 2019) – 190 articles
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Cover Story (view full-size image) The growing reality of antimicrobial resistance requires an ongoing effort to discover new [...] Read more. The growing reality of antimicrobial resistance requires an ongoing effort to discover new anti-infective agents. Nature is replete with such molecules produced by plants and microbes as a defence against parasites, fungi, and bacteria. Bees have evolved to harvest plant resins using the very best antimicrobial product, propolis, which they apply to the hive to prevent diseases. We analysed Libyan propolis for the presence of agents against various parasites and found several new molecules with excellent activity against Trypanosoma brucei, a protozoan related to a bee pathogen, which causes sleeping sickness. These new agents do not interfere with current treatments, as they have a different mechanism of action in the parasite, which we investigated using metabolomics. This study confirms propolis as a rich source of potent and novel antiparasitic drugs. View this paper.