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Four Novel Dammarane-Type Triterpenoids from Pearl Knots of Panax ginseng Meyer cv. Silvatica

1
School of Pharmaceutical Sciences, Jilin University, Changchun 130021, China
2
Basic Medical College, Jilin University, Changchun 130021, China
*
Authors to whom correspondence should be addressed.
Academic Editor: Isabel C.F.R. Ferreira
Molecules 2019, 24(6), 1159; https://doi.org/10.3390/molecules24061159
Received: 4 March 2019 / Revised: 18 March 2019 / Accepted: 21 March 2019 / Published: 23 March 2019
(This article belongs to the Collection Bioactive Compounds)
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Abstract

Panax ginseng Meyer cv. Silvatica (PGS), which is also known as “Lin-Xia-Shan-Shen” or “Zi-Hai” in China, is grown in forests and mountains by broadcasting the seeds of ginseng and is harvested at the cultivation age of 15–20 years. In this study, four new dammarane-type triterpenoids, ginsengenin-S1 (1), ginsengenin-S2 (2), ginsenoside-S3 (3), ginsenoside-S4 (4), along with one known compound were isolated from pearl knots of PGS. Ginsengenin-S2 significantly alleviated oxidative damage when A549 cells were exposed to cigarette smoke (CS) extract. In addition, ginsengenin-S2 could inhibit the CS-induced inflammatory reaction in A549 cells. Protective effects of ginsengenin-S2 against CS-mediated oxidative stress and the inflammatory response in A549 cells may involve the Nrf2 and HDAC2 pathways. View Full-Text
Keywords: Panax ginseng Meyer cv. Silvatica; new dammarane-type triterpenoids; cigarette smoke; oxidative stress; inflammation Panax ginseng Meyer cv. Silvatica; new dammarane-type triterpenoids; cigarette smoke; oxidative stress; inflammation
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Qi, Z.; Li, Z.; Guan, X.; Wang, C.; Wang, F.; Li, P.; Liu, J. Four Novel Dammarane-Type Triterpenoids from Pearl Knots of Panax ginseng Meyer cv. Silvatica. Molecules 2019, 24, 1159.

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