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Natural Products and Obesity: A Focus on the Regulation of Mitotic Clonal Expansion during Adipogenesis

1
Department of Nutritional Science and Food Management, Ewha Womans University, Seoul 03760, Korea
2
Department of Food and Nutrition, Yeungnam University, Gyeongsan 38541, Gyeongbuk, Korea
*
Author to whom correspondence should be addressed.
Academic Editors: Min-Hsiung Pan and Filomena Conforti
Molecules 2019, 24(6), 1157; https://doi.org/10.3390/molecules24061157
Received: 8 February 2019 / Revised: 18 March 2019 / Accepted: 18 March 2019 / Published: 23 March 2019
(This article belongs to the Special Issue Natural Bioactives in Anti-Obesity Therapy)
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Abstract

Obesity is recognized as a worldwide health crisis. Obesity and its associated health complications such as diabetes, dyslipidemia, hypertension, and cardiovascular diseases impose a big social and economic burden. In an effort to identify safe, efficient, and long-term effective methods to treat obesity, various natural products with potential for inhibiting adipogenesis were revealed. This review aimed to discuss the molecular mechanisms underlying adipogenesis and the inhibitory effects of various phytochemicals, including those from natural sources, on the early stage of adipogenesis. We discuss key steps (proliferation and cell cycle) and their regulators (cell-cycle regulator, transcription factors, and intracellular signaling pathways) at the early stage of adipocyte differentiation as the mechanisms responsible for obesity. View Full-Text
Keywords: obesity; adipocyte differentiation; adipogenesis; natural products; 3T3-L1 preadipocytes obesity; adipocyte differentiation; adipogenesis; natural products; 3T3-L1 preadipocytes
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Chang, E.; Kim, C.Y. Natural Products and Obesity: A Focus on the Regulation of Mitotic Clonal Expansion during Adipogenesis. Molecules 2019, 24, 1157.

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