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Open AccessArticle

Hydrogen Gas Alleviates Chronic Intermittent Hypoxia-Induced Renal Injury through Reducing Iron Overload

1
Department of Physiology, Hebei University of Chinese Medicine, Shijiazhuang 050200, Hebei, China
2
Scientific Research Center, Hebei University of Chinese Medicine, Shijiazhuang 050200, Hebei, China
*
Author to whom correspondence should be addressed.
The authors contributed equally to this manuscript.
Academic Editors: Luciano Saso, Neda Mimica-Dukić and Ryszard Amarowicz
Molecules 2019, 24(6), 1184; https://doi.org/10.3390/molecules24061184
Received: 11 March 2019 / Revised: 23 March 2019 / Accepted: 25 March 2019 / Published: 26 March 2019
(This article belongs to the Special Issue Chemistry and Pharmacology of Modulators of Oxidative Stress 2018)
Iron-induced oxidative stress has been found to be a central player in the pathogenesis of kidney injury. Recent studies have indicated H2 can be used as a novel antioxidant to protect cells. The present study was designed to investigate the protective effects of H2 against chronic intermittent hypoxia (CIH)-induced renal injury and its correlation mechanism involved in iron metabolism. We found that CIH-induced renal iron overloaded along with increased apoptosis and oxidative stress. Iron accumulates mainly occurred in the proximal tubule epithelial cells of rats as showed by Perl’s stain. Moreover, we found that CIH could promote renal transferrin receptor and divalent metal transporter-1 expression, inhibit ceruloplasmin expression. Renal injury, apoptosis and oxidative stress induced by CIH were strikingly attenuated in H2 treated rats. In conclusion, hydrogen may attenuate CIH-induced renal injury at least partially via inhibiting renal iron overload. View Full-Text
Keywords: hydrogen; chronic intermittent hypoxia; kidney; iron hydrogen; chronic intermittent hypoxia; kidney; iron
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MDPI and ACS Style

Guan, P.; Sun, Z.-M.; Luo, L.-F.; Zhao, Y.-S.; Yang, S.-C.; Yu, F.-Y.; Wang, N.; Ji, E.-S. Hydrogen Gas Alleviates Chronic Intermittent Hypoxia-Induced Renal Injury through Reducing Iron Overload. Molecules 2019, 24, 1184.

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