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Effect of Selected Stilbenoids on Human Fecal Microbiota
Open AccessArticle

Metabolism of Stilbenoids by Human Faecal Microbiota

1
Department of Food Science, Czech University of Life Sciences Prague, Kamycka 129, 165 00 Prague 6–Suchdol, Czech Republic
2
Department of Microbiology, Nutrition and Dietetics, Czech University of Life Sciences Prague, Kamycka 129, 165 00 Prague 6– Suchdol, Czech Republic
3
Department of Natural Drugs, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences Brno, Palackeho 1946/1, 612 42 Brno, Czech Republic
*
Author to whom correspondence should be addressed.
Academic Editors: Pedro Mena and Rafael Llorach Asunción
Molecules 2019, 24(6), 1155; https://doi.org/10.3390/molecules24061155
Received: 18 February 2019 / Revised: 14 March 2019 / Accepted: 18 March 2019 / Published: 23 March 2019
Stilbenoids are dietary phenolics with notable biological effects on humans. Epidemiological, clinical, and nutritional studies from recent years have confirmed the significant biological effects of stilbenoids, such as oxidative stress protection and the prevention of degenerative diseases, including cancer, cardiovascular diseases, and neurodegenerative diseases. Stilbenoids are intensively metabolically transformed by colon microbiota, and their corresponding metabolites might show different or stronger biological activity than their parent molecules. The aim of the present study was to determine the metabolism of six stilbenoids (resveratrol, oxyresveratrol, piceatannol, thunalbene, batatasin III, and pinostilbene), mediated by colon microbiota. Stilbenoids were fermented in an in vitro faecal fermentation system using fresh faeces from five different donors as an inoculum. The samples of metabolized stilbenoids were collected at 0, 2, 4, 8, 24, and 48 h. Significant differences in the microbial transformation among stilbene derivatives were observed by liquid chromatography mass spectrometry (LC/MS). Four stilbenoids (resveratrol, oxyresveratrol, piceatannol and thunalbene) were metabolically transformed by double bond reduction, dihydroxylation, and demethylation, while batatasin III and pinostilbene were stable under conditions simulating the colon environment. Strong inter-individual differences in speed, intensity, and pathways of metabolism were observed among the faecal samples obtained from the donors. View Full-Text
Keywords: bacteria colon model; fecal fermentation; metabolites; phenolics; polyphenols; stilbenoids; liquid chromatography high resolution mass spectrometry bacteria colon model; fecal fermentation; metabolites; phenolics; polyphenols; stilbenoids; liquid chromatography high resolution mass spectrometry
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MDPI and ACS Style

Jarosova, V.; Vesely, O.; Marsik, P.; Jaimes, J.D.; Smejkal, K.; Kloucek, P.; Havlik, J. Metabolism of Stilbenoids by Human Faecal Microbiota. Molecules 2019, 24, 1155.

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